Hypoxia-Inducible Factor 1, alpha Subunit
"Hypoxia-Inducible Factor 1, alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.
| Descriptor ID |
D051795
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| MeSH Number(s) |
D12.776.260.103.625.750 D12.776.930.125.625.750
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Hypoxia-Inducible Factor 1, alpha Subunit".
Below are MeSH descriptors whose meaning is more specific than "Hypoxia-Inducible Factor 1, alpha Subunit".
This graph shows the total number of publications written about "Hypoxia-Inducible Factor 1, alpha Subunit" by people in this website by year, and whether "Hypoxia-Inducible Factor 1, alpha Subunit" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 2 | 2 |
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 4 | 4 |
| 2005 | 1 | 1 | 2 |
| 2006 | 4 | 1 | 5 |
| 2007 | 3 | 2 | 5 |
| 2008 | 4 | 0 | 4 |
| 2009 | 2 | 3 | 5 |
| 2010 | 2 | 1 | 3 |
| 2011 | 3 | 0 | 3 |
| 2012 | 1 | 5 | 6 |
| 2013 | 2 | 5 | 7 |
| 2014 | 5 | 6 | 11 |
| 2015 | 5 | 8 | 13 |
| 2016 | 1 | 4 | 5 |
| 2017 | 4 | 2 | 6 |
| 2018 | 2 | 3 | 5 |
| 2019 | 1 | 3 | 4 |
| 2020 | 2 | 1 | 3 |
| 2021 | 3 | 2 | 5 |
| 2022 | 1 | 2 | 3 |
| 2024 | 0 | 2 | 2 |
| 2025 | 2 | 1 | 3 |
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Below are the most recent publications written about "Hypoxia-Inducible Factor 1, alpha Subunit" by people in Profiles.
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HIF-1 regulates mitochondrial function in bone marrow-derived macrophages but not in tissue-resident alveolar macrophages. Sci Rep. 2025 Apr 04; 15(1):11574.
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Dynamic investigation of hypoxia-induced L-lactylation. Proc Natl Acad Sci U S A. 2025 Mar 11; 122(10):e2404899122.
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Sustained hypoxia but not intermittent hypoxia induces HIF-1a transcriptional response in human aortic endothelial cells. Mol Omics. 2025 Jan 13; 21(1):19-31.
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Direct inhibition of tumor hypoxia response with synthetic transcriptional repressors. Nat Chem Biol. 2025 Feb; 21(2):247-255.
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P300/CBP Regulates HIF-1-Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia. Am J Respir Cell Mol Biol. 2024 Feb; 70(2):110-118.
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HIF-1a induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury. Elife. 2022 07 13; 11.
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Protein phosphatase 1 regulates reactive oxygen species-dependent degradation of histone deacetylase 5 by intermittent hypoxia. Am J Physiol Cell Physiol. 2022 08 01; 323(2):C423-C431.
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Cardiac macrophages regulate isoproterenol-induced Takotsubo-like cardiomyopathy. JCI Insight. 2022 02 08; 7(3).
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Host-Microbiota Interactions in the Esophagus During Homeostasis and Allergic Inflammation. Gastroenterology. 2022 02; 162(2):521-534.e8.
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HIF1a is required for NK cell metabolic adaptation during virus infection. Elife. 2021 08 16; 10.