Hypoxia-Inducible Factor 1, alpha Subunit
"Hypoxia-Inducible Factor 1, alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.
| Descriptor ID |
D051795
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| MeSH Number(s) |
D12.776.260.103.625.750 D12.776.930.125.625.750
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Hypoxia-Inducible Factor 1, alpha Subunit".
Below are MeSH descriptors whose meaning is more specific than "Hypoxia-Inducible Factor 1, alpha Subunit".
This graph shows the total number of publications written about "Hypoxia-Inducible Factor 1, alpha Subunit" by people in this website by year, and whether "Hypoxia-Inducible Factor 1, alpha Subunit" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 2 | 2 |
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 4 | 4 |
| 2005 | 1 | 0 | 1 |
| 2006 | 4 | 1 | 5 |
| 2007 | 3 | 2 | 5 |
| 2008 | 4 | 0 | 4 |
| 2009 | 2 | 2 | 4 |
| 2010 | 2 | 1 | 3 |
| 2011 | 3 | 0 | 3 |
| 2012 | 1 | 5 | 6 |
| 2013 | 3 | 4 | 7 |
| 2014 | 5 | 5 | 10 |
| 2015 | 5 | 6 | 11 |
| 2016 | 1 | 4 | 5 |
| 2017 | 4 | 2 | 6 |
| 2018 | 2 | 3 | 5 |
| 2019 | 1 | 3 | 4 |
| 2020 | 1 | 1 | 2 |
| 2021 | 2 | 2 | 4 |
| 2022 | 0 | 2 | 2 |
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Below are the most recent publications written about "Hypoxia-Inducible Factor 1, alpha Subunit" by people in Profiles.
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HIF-1a induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury. Elife. 2022 07 13; 11.
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Protein phosphatase 1 regulates reactive oxygen species-dependent degradation of histone deacetylase 5 by intermittent hypoxia. Am J Physiol Cell Physiol. 2022 08 01; 323(2):C423-C431.
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Host-Microbiota Interactions in the Esophagus During Homeostasis and Allergic Inflammation. Gastroenterology. 2022 02; 162(2):521-534.e8.
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Lysine demethylase KDM6B regulates HIF-1a-mediated systemic and cellular responses to intermittent hypoxia. Physiol Genomics. 2021 09 01; 53(9):385-394.
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Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation. J Clin Invest. 2021 07 01; 131(13).
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The relationship between expression of PD-L1 and HIF-1a in glioma cells under hypoxia. J Hematol Oncol. 2021 06 12; 14(1):92.
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Hypoxia-inducible factor-1 mediates pancreatic ?-cell dysfunction by intermittent hypoxia. Am J Physiol Cell Physiol. 2020 11 01; 319(5):C922-C932.
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Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis. Circ Res. 2020 06 05; 126(12):1723-1745.
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Mesothelial Cell HIF1a Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk. Cell Rep. 2019 12 17; 29(12):4086-4098.e6.
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Very Severe Resistance to Thyroid Hormone ? in One of Three Affected Members of a Family with a Novel Mutation in the THRB Gene. Thyroid. 2019 10; 29(10):1518-1520.