 Pancreatic Polypeptide
"Pancreatic Polypeptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.
| Descriptor ID |
D010191
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| MeSH Number(s) |
D06.472.699.587.700 D12.644.400.600 D12.644.548.586.700 D12.776.641.650.600
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Pancreatic Polypeptide".
Below are MeSH descriptors whose meaning is more specific than "Pancreatic Polypeptide".
This graph shows the total number of publications written about "Pancreatic Polypeptide" by people in this website by year, and whether "Pancreatic Polypeptide" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 0 | 1 | 1 | | 1983 | 3 | 0 | 3 | | 1984 | 1 | 0 | 1 | | 1986 | 1 | 1 | 2 | | 1988 | 1 | 0 | 1 | | 1993 | 1 | 0 | 1 | | 1998 | 0 | 1 | 1 | | 2000 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Pancreatic Polypeptide" by people in Profiles.
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Nagpal SJS, Bamlet WR, Kudva YC, Chari ST. Comparison of Fasting Human Pancreatic Polypeptide Levels Among Patients With Pancreatic Ductal Adenocarcinoma, Chronic Pancreatitis, and Type 2 Diabetes Mellitus. Pancreas. 2018 07; 47(6):738-741.
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Herrera MF, Åkerström G, Angelos P, Grant CS, Hoff AO, Pantoja JP, Pérez-Johnston R, Sahani DV, Wong RJ, Randolph G. AACE/ACE disease state clinical review: pancreatic neuroendocrine incidentalomas. Endocr Pract. 2015 May; 21(5):546-53.
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Ilag LL, Tabaei BP, Herman WH, Zawacki CM, D'Souza E, Bell GI, Fajans SS. Reduced pancreatic polypeptide response to hypoglycemia and amylin response to arginine in subjects with a mutation in the HNF-4alpha/MODY1 gene. Diabetes. 2000 Jun; 49(6):961-8.
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Pick A, Clark J, Kubstrup C, Levisetti M, Pugh W, Bonner-Weir S, Polonsky KS. Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. Diabetes. 1998 Mar; 47(3):358-64.
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Foucart S, Bleakman D, Bindokas VP, Miller RJ. Neuropeptide Y and pancreatic polypeptide reduce calcium currents in acutely dissociated neurons from adult rat superior cervical ganglia. J Pharmacol Exp Ther. 1993 May; 265(2):903-9.
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Seino S, Blackstone CD, Chan SJ, Whittaker J, Bell GI, Steiner DF. Appalachian spring: variations on ancient gastro-entero-pancreatic themes in New World mammals. Horm Metab Res. 1988 Jul; 20(7):430-5.
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Jaspan JB, Lever E, Polonsky KS, Van Cauter E. In vivo pulsatility of pancreatic islet peptides. Am J Physiol. 1986 Aug; 251(2 Pt 1):E215-26.
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Kaplan EL, Michelassi F. Endocrine tumors of the pancreas and their clinical syndromes. Surg Annu. 1986; 18:181-223.
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Cohen DM, Jaspan JB, Polonsky KS, Lever EG, Moossa AR. Pancreatic hormone profiles and metabolism posthepatectomy in the dog. Evidence for a hepatotrophic role of insulin, glucagon, and pancreatic polypeptide. Gastroenterology. 1984 Sep; 87(3):679-87.
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Prinz RA, El Sabbagh H, Adrian TE, Bloom SR, Gardner I, Polak JM, Inokuchi H, Bishop AE, Welbourn RB. Neural regulation of pancreatic polypeptide release. Surgery. 1983 Dec; 94(6):1011-8.
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