Islet Amyloid Polypeptide
"Islet Amyloid Polypeptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pancreatic beta-cell hormone that is co-secreted with INSULIN. It displays an anorectic effect on nutrient metabolism by inhibiting gastric acid secretion, gastric emptying and postprandial GLUCAGON secretion. Islet amyloid polypeptide can fold into AMYLOID FIBRILS that have been found as a major constituent of pancreatic AMYLOID DEPOSITS.
| Descriptor ID |
D058228
|
| MeSH Number(s) |
D06.472.699.587.334 D12.644.548.586.234 D12.776.049.407.500
|
| Concept/Terms |
Islet Amyloid Polypeptide- Islet Amyloid Polypeptide
- Amyloid Polypeptide, Islet
- Polypeptide, Islet Amyloid
- Pancreatic Amylin
- Amylin, Pancreatic
- IAPP Protein
- Insulinoma Amyloid Polypeptide
- Amyloid Polypeptide, Insulinoma
- Polypeptide, Insulinoma Amyloid
- Amlintide
- Amylin
|
Below are MeSH descriptors whose meaning is more general than "Islet Amyloid Polypeptide".
Below are MeSH descriptors whose meaning is more specific than "Islet Amyloid Polypeptide".
This graph shows the total number of publications written about "Islet Amyloid Polypeptide" by people in this website by year, and whether "Islet Amyloid Polypeptide" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2012 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2023 | 2 | 1 | 3 |
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Below are the most recent publications written about "Islet Amyloid Polypeptide" by people in Profiles.
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Skin capillary amylin deposition resembles brain amylin vasculopathy in rats. J Stroke Cerebrovasc Dis. 2023 Sep; 32(9):107300.
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Rapid, scalable assay of amylin-ß amyloid co-aggregation in brain tissue and blood. J Biol Chem. 2023 05; 299(5):104682.
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Aß efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas. Commun Biol. 2023 01 03; 6(1):2.
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Amylin Dyshomeostasis Hypothesis: Small Vessel-Type Ischemic Stroke in the Setting of Type-2 Diabetes. Stroke. 2021 06; 52(6):e244-e249.
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Amylin as a Potential Link between Type 2 Diabetes and Alzheimer Disease. Ann Neurol. 2020 03; 87(3):486.
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Diabetic microcirculatory disturbances and pathologic erythropoiesis are provoked by deposition of amyloid-forming amylin in red blood cells and capillaries. Kidney Int. 2020 01; 97(1):143-155.
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Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity. Cell. 2018 03 22; 173(1):62-73.e9.
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Brain microvascular injury and white matter disease provoked by diabetes-associated hyperamylinemia. Ann Neurol. 2017 Aug; 82(2):208-222.
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In vivo measurement and biological characterisation of the diabetes-associated mutant insulin p.R46Q (GlnB22-insulin). Diabetologia. 2017 08; 60(8):1423-1431.
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Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus. Trends Endocrinol Metab. 2016 Jan; 27(1):24-34.