 Monocarboxylic Acid Transporters
"Monocarboxylic Acid Transporters" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proteins involved in the transport of monocarboxylic acids such as LACTIC ACID and PYRUVIC ACID across cellular membranes.
| Descriptor ID |
D027501
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| MeSH Number(s) |
D12.776.157.530.450.074.500.400 D12.776.543.585.450.074.500.300
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| Concept/Terms |
Monocarboxylic Acid Transporters- Monocarboxylic Acid Transporters
- Acid Transporters, Monocarboxylic
- Transporters, Monocarboxylic Acid
- Monocarboxylate Translocator
- Translocator, Monocarboxylate
- Monocarboxylic Acid Transport Proteins
- MCT Proteins
- Monocarboxylic Acid Transport Protein
Erythrocyte Lactate Transporters- Erythrocyte Lactate Transporters
- Lactate Transporters, Erythrocyte
- Transporters, Erythrocyte Lactate
- Erythrocyte Lactate Transporter
- Lactate Transporter, Erythrocyte
- Transporter, Erythrocyte Lactate
Lactate Transport Proteins- Lactate Transport Proteins
- Transport Proteins, Lactate
- Lactate Transport Protein
- Transport Protein, Lactate
- Lactate Transporter
- Transporter, Lactate
- Lactate Translocase
- Translocase, Lactate
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Below are MeSH descriptors whose meaning is more general than "Monocarboxylic Acid Transporters".
Below are MeSH descriptors whose meaning is more specific than "Monocarboxylic Acid Transporters".
This graph shows the total number of publications written about "Monocarboxylic Acid Transporters" by people in this website by year, and whether "Monocarboxylic Acid Transporters" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2003 | 1 | 0 | 1 | | 2005 | 1 | 1 | 2 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 2 | 3 | | 2008 | 1 | 0 | 1 | | 2009 | 1 | 3 | 4 | | 2010 | 0 | 2 | 2 | | 2011 | 1 | 1 | 2 | | 2012 | 2 | 0 | 2 | | 2013 | 1 | 4 | 5 | | 2014 | 1 | 3 | 4 | | 2015 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 | | 2017 | 1 | 2 | 3 | | 2019 | 2 | 0 | 2 | | 2020 | 2 | 1 | 3 | | 2021 | 1 | 0 | 1 | | 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Monocarboxylic Acid Transporters" by people in Profiles.
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Liao XH, Avalos P, Shelest O, Ofan R, Shilo M, Bresee C, Likhite S, Vit JP, Heuer H, Kaspar B, Meyer K, Dumitrescu AM, Refetoff S, Svendsen CN, Vatine GD. AAV9-MCT8 Delivery at Juvenile Stage Ameliorates Neurological and Behavioral Deficits in a Mouse Model of MCT8-Deficiency. Thyroid. 2022 07; 32(7):849-859.
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Iwayama H, Kakita H, Iwasa M, Adachi S, Takano K, Kikuchi M, Fujisawa Y, Osaka H, Yamada Y, Okumura A, Hirani K, Weiss RE, Refetoff S. Measurement of Reverse Triiodothyronine Level and the Triiodothyronine to Reverse Triiodothyronine Ratio in Dried Blood Spot Samples at Birth May Facilitate Early Detection of Monocarboxylate Transporter 8 Deficiency. Thyroid. 2021 09; 31(9):1316-1321.
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Refetoff S, Pappa T, Williams MK, Matheus MG, Liao XH, Hansen K, Nicol L, Pierce M, Blasco PA, Wiebers Jensen M, Bernal J, Weiss RE, Dumitrescu AM, LaFranchi S. Prenatal Treatment of Thyroid Hormone Cell Membrane Transport Defect Caused by MCT8 Gene Mutation. Thyroid. 2021 05; 31(5):713-720.
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Grijota-Martínez C, Bárez-López S, Ausó E, Refetoff S, Frey WH, Guadaño-Ferraz A. Intranasal delivery of Thyroid hormones in MCT8 deficiency. PLoS One. 2020; 15(7):e0236113.
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Fu J, Korwutthikulrangsri M, Ramos-Platt L, Pierson TM, Liao XH, Refetoff S, Weiss RE, Dumitrescu AM. Sorting Variants of Unknown Significance Identified by Whole Exome Sequencing: Genetic and Laboratory Investigations of Two Novel MCT8 Variants. Thyroid. 2020 03; 30(3):463-465.
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Tasdogan A, Faubert B, Ramesh V, Ubellacker JM, Shen B, Solmonson A, Murphy MM, Gu Z, Gu W, Martin M, Kasitinon SY, Vandergriff T, Mathews TP, Zhao Z, Schadendorf D, DeBerardinis RJ, Morrison SJ. Metabolic heterogeneity confers differences in melanoma metastatic potential. Nature. 2020 01; 577(7788):115-120.
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Bárez-López S, Grijota-Martínez C, Liao XH, Refetoff S, Guadaño-Ferraz A. Intracerebroventricular administration of the thyroid hormone analog TRIAC increases its brain content in the absence of MCT8. PLoS One. 2019; 14(12):e0226017.
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Faubert B, Li KY, Cai L, Hensley CT, Kim J, Zacharias LG, Yang C, Do QN, Doucette S, Burguete D, Li H, Huet G, Yuan Q, Wigal T, Butt Y, Ni M, Torrealba J, Oliver D, Lenkinski RE, Malloy CR, Wachsmann JW, Young JD, Kernstine K, DeBerardinis RJ. Lactate Metabolism in Human Lung Tumors. Cell. 2017 Oct 05; 171(2):358-371.e9.
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Leitch VD, Di Cosmo C, Liao XH, O'Boy S, Galliford TM, Evans H, Croucher PI, Boyde A, Dumitrescu A, Weiss RE, Refetoff S, Williams GR, Bassett JHD. An Essential Physiological Role for MCT8 in Bone in Male Mice. Endocrinology. 2017 09 01; 158(9):3055-3066.
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Vatine GD, Al-Ahmad A, Barriga BK, Svendsen S, Salim A, Garcia L, Garcia VJ, Ho R, Yucer N, Qian T, Lim RG, Wu J, Thompson LM, Spivia WR, Chen Z, Van Eyk J, Palecek SP, Refetoff S, Shusta EV, Svendsen CN. Modeling Psychomotor Retardation using iPSCs from MCT8-Deficient Patients Indicates a Prominent Role for the Blood-Brain Barrier. Cell Stem Cell. 2017 06 01; 20(6):831-843.e5.
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