A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.

Descriptor ID	D011266
MeSH Number(s)	D08.811.277.656.300.480.632 D08.811.277.656.675.374.632 D12.776.780.700
Concept/Terms	Pregnancy-Associated Plasma Protein-A Pregnancy-Associated Plasma Protein-A Pregnancy Associated Plasma Protein A IGFBP-4 Protease IGFBP 4 Protease Protease, IGFBP-4 IGFBP-4-Specific Proteinase Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease Insulin Like Growth Factor Dependent IGF Binding Protein 4 Protease PAPP-A PAPP-alpha PAPP alpha Pregnancy Associated alpha Plasma Protein Pregnancy-Associated alpha-Plasma Protein IGFBP-4 Metalloproteinase IGFBP 4 Metalloproteinase Metalloproteinase, IGFBP-4 Insulin-Like-Growth Factor Binding Protein-4 Protease Insulin Like Growth Factor Binding Protein 4 Protease

Below are MeSH descriptors whose meaning is more general than "Pregnancy-Associated Plasma Protein-A".

Below are MeSH descriptors whose meaning is related to "Pregnancy-Associated Plasma Protein-A".

Below are MeSH descriptors whose meaning is more specific than "Pregnancy-Associated Plasma Protein-A".