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Axel Concepcion

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentBiochemistry and Molecular Biology
AddressChicago IL 60637
ORCID ORCID Icon0000-0003-2971-3488 Additional info
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    Collapse Overview 
    Collapse overview
    Our laboratory seeks to understand how membrane proteins and ion channels regulate the function of immune cells in health and disease. We use functional genomics and forward genetic screens to identify novel membrane proteins and ion channel regulators of immune cells. Our research team combines cross-disciplinary approaches including functional genomics, systems immunology, electrophysiology, and a wide range of cell and molecular biology techniques to understand the complex molecular networks regulated by ion channels in immune cells. Our goal is to advance our knowledge of how these plasma membrane proteins coordinate the immune responses to make fundamental and translational advances in immunotherapy.

    Collapse Biography 
    Collapse education and training
    NYU School of Medicine, New YorkPostdoc06/2022Immunology
    Center for Applied Medical Research, SpainPostdoc10/2014Immunology
    University of Navarra, SpainPhD.09/2012Cell & Molecular Biology, Immunology
    University of Navarra, SpainMSc.09/2008Cell & Molecular Biology
    University of Panama, PanamaBSc.05/2007Chemical Technology
    Collapse awards and honors
    2022 - 2027Neubauer Family Assistant Professorship, The University of Chicago
    2018 - 2020Bernard B. Levine Postdoctoral Fellowship in Immunology, NYU Grossman School of Medicine
    2015 - 2017Alfonso Martin Escudero Postdoctoral Fellowship, Alfonso Martin Escudero Foundation, Spain
    2010 - 2013Torres Quevedo Award, Ministry of Science and Innovation, Spain
    2008 - 2012Excellence Scholarship, Foundation for Applied Medical Research, Spain
    2007Grupo Adelante Short-term Fellowship Award, Smithsonian Tropical Research Institute, Panama
    2007Short-term Fellowship Award, International Cooperative Group on Biodiversity, Panama
    2005Alan P. Smith Short-term Fellowship Award, Smithsonian Tropical Research Institute, Panama

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Remark J, Tong J, Lin MJ, Concepcion A, Mareedu S, Babu GJ, Feske S, Lu CP. Neurotransmitter signaling specifies sweat gland stem cell fate through SLN-mediated intracellular calcium regulation. bioRxiv. 2023 Sep 13. PMID: 37745514; PMCID: PMC10515797.
    2. Erdogmus S, Concepcion AR, Yamashita M, Sidhu I, Tao AY, Li W, Rocha PP, Huang B, Garippa R, Lee B, Lee A, Hell JW, Lewis RS, Prakriya M, Feske S. Cavß1 regulates T cell expansion and apoptosis independently of voltage-gated Ca2+ channel function. Nat Commun. 2022 04 19; 13(1):2033. PMID: 35440113; PMCID: PMC9018955.
      Citations: 9     Fields:    Translation:AnimalsCells
    3. Concepcion AR, Wagner LE, Zhu J, Tao AY, Yang J, Khodadadi-Jamayran A, Wang YH, Liu M, Rose RE, Jones DR, Coetzee WA, Yule DI, Feske S. The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING-p53 signaling. Nat Immunol. 2022 02; 23(2):287-302. PMID: 35105987; PMCID: PMC8991407.
      Citations: 21     Fields:    Translation:AnimalsCells
    4. Kahlfuss S, Kaufmann U, Concepcion AR, Noyer L, Raphael D, Vaeth M, Yang J, Pancholi P, Maus M, Muller J, Kozhaya L, Khodadadi-Jamayran A, Sun Z, Shaw P, Unutmaz D, Stathopulos PB, Feist C, Cameron SB, Turvey SE, Feske S. STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells. EMBO Mol Med. 2020 08 07; 12(8):e11592. PMID: 32609955; PMCID: PMC7411566.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    5. Aulestia FJ, Groeling J, Bomfim GHS, Costiniti V, Manikandan V, Chaloemtoem A, Concepcion AR, Li Y, Wagner LE, Idaghdour Y, Yule DI, Lacruz RS. Fluoride exposure alters Ca2+ signaling and mitochondrial function in enamel cells. Sci Signal. 2020 02 18; 13(619). PMID: 32071168; PMCID: PMC7173621.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    6. Feske S, Concepcion AR, Coetzee WA. Eye on ion channels in immune cells. Sci Signal. 2019 03 12; 12(572). PMID: 30862701.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    7. Celay J, Lozano T, Concepcion AR, Rudilla F, Robles EF, Rabal O, de Miguel I, Panizo C, Casares N, Oyarzabal J, Medina JF, Beltrán E, García-Barchino MJ, Prieto J, Lasarte JJ, Martínez-Climent JÁ. Targeting the anion exchanger 2 with specific peptides as a new therapeutic approach in B lymphoid neoplasms. Haematologica. 2018 06; 103(6):1065-1072. PMID: 29191842; PMCID: PMC6058773.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    8. Concepcion AR, Feske S. Regulation of epithelial ion transport in exocrine glands by store-operated Ca2+ entry. Cell Calcium. 2017 05; 63:53-59. PMID: 28027799; PMCID: PMC5466487.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    9. Concepcion AR, Vaeth M, Wagner LE, Eckstein M, Hecht L, Yang J, Crottes D, Seidl M, Shin HP, Weidinger C, Cameron S, Turvey SE, Issekutz T, Meyts I, Lacruz RS, Cuk M, Yule DI, Feske S. Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function. J Clin Invest. 2016 11 01; 126(11):4303-4318. PMID: 27721237; PMCID: PMC5096923.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    10. Nurbaeva MK, Eckstein M, Concepcion AR, Smith CE, Srikanth S, Paine ML, Gwack Y, Hubbard MJ, Feske S, Lacruz RS. Dental enamel cells express functional SOCE channels. Sci Rep. 2015 Oct 30; 5:15803. PMID: 26515404; PMCID: PMC4626795.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    11. Concepcion AR, Salas JT, Sarvide S, Ferrer A, Portu A, Uriarte I, Oude Elferink RP, Medina JF, Sáez E, Hervás-Stubbs S, Prieto J. CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b-/- mice favoring autoimmune cholangitis. Oncotarget. 2015 Oct 06; 6(30):28588-606. PMID: 26396175; PMCID: PMC4745679.
      Citations: 14     Fields:    Translation:AnimalsCells
    12. Vaeth M, Zee I, Concepcion AR, Maus M, Shaw P, Portal-Celhay C, Zahra A, Kozhaya L, Weidinger C, Philips J, Unutmaz D, Feske S. Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells. J Immunol. 2015 Aug 01; 195(3):1202-17. PMID: 26109647; PMCID: PMC4506881.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    13. Urribarri AD, Sarvide S, Portu A, Concepcion AR, Romero MR, Beuers U, Masyuk TV, LaRusso NF, Drenth JP, Munoz-Garrido P, Marin JJ, Perugorria MJ, Erice O, Sáez E, Úriz M, Monte MJ, Santos-Laso Á, Hijona E, Jimenez-Agüero R, Marzioni M, Prieto J, Bujanda L, Banales JM. Ursodeoxycholic acid inhibits hepatic cystogenesis in experimental models of polycystic liver disease. J Hepatol. 2015 Oct; 63(4):952-61. PMID: 26044126; PMCID: PMC4575914.
      Citations: 25     Fields:    Translation:AnimalsCells
    14. Concepcion AR, Medina JF. Mouse models of primary biliary cirrhosis. Curr Pharm Des. 2015; 21(18):2401-13. PMID: 25777756.
      Citations: 2     Fields:    Translation:HumansAnimals
    15. Concepcion AR, Salas JT, Sarvide S, Ferrer A, Portu A, Oude Elferink RP, Medina JF, Sáez E, López M, Banales JM, Hervás-Stubbs S, Prieto J. Anion exchanger 2 is critical for CD8(+) T cells to maintain pHi homeostasis and modulate immune responses. Eur J Immunol. 2014 May; 44(5):1341-51. PMID: 24515893.
      Citations: 15     Fields:    Translation:AnimalsCells
    16. Concepcion AR, Ardura-Fabregat A, Medina JF, Lopez M. Role of AE2 for pHi regulation in biliary epithelial cells. Front Physiol. 2013; 4:413. PMID: 24478713; PMCID: PMC3894451.
      Citations: 17     
    17. Uriarte I, Fernandez-Barrena MG, Monte MJ, Latasa MU, Chang HC, Carotti S, Vespasiani-Gentilucci U, Morini S, Vicente E, Concepcion AR, Medina JF, Berasain C, Prieto J, Marin JJ, Avila MA. Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice. Gut. 2013 Jun; 62(6):899-910. PMID: 23292666.
      Citations: 75     Fields:    Translation:Animals
    18. Concepcion AR, Medina JF. Approaches to the pathogenesis of primary biliary cirrhosis through animal models. Clin Res Hepatol Gastroenterol. 2012 Feb; 36(1):21-8. PMID: 21862437.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
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