Spironolactone
"Spironolactone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
Descriptor ID |
D013148
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MeSH Number(s) |
D02.540.679 D04.808.745.745.855
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Concept/Terms |
Spiractin- Spiractin
- Alphapharm Brand of Spironolactone
Spirobeta- Spirobeta
- betapharm Brand of Spironolactone
Spirogamma- Spirogamma
- Wörwag Brand of Spironolactone
Spirono-Isis- Spirono-Isis
- Spirono Isis
- Alpharma Brand of Spironolactone
Spironone- Spironone
- Dexo Brand of Spironolactone
Spirospare- Spirospare
- Ashbourne Brand of Spironolactone
Verospiron- Verospiron
- Hormosan Brand of Spironolactone
Aldactone- Aldactone
- Roche Brand of Spironolactone
- Searle Brand of Spironolactone
- Pfizer Brand of Spironolactone
Aquareduct- Aquareduct
- Azupharma Brand of Spironolactone
duraspiron- duraspiron
- Merck dura Brand of Spironolactone
Flumach- Flumach
- Mayoly-Spindler Brand of Spironolactone
Frumikal- Frumikal
- Generosan Brand of Spironolactone
Jenaspiron- Jenaspiron
- Jenapharm Brand of Spironolactone
Novo-Spiroton- Novo-Spiroton
- Novo Spiroton
- NovoSpiroton
- Novopharm Brand of Spironolactone
Practon- Practon
- Cardel Brand of Spironolactone
spiro von ct- spiro von ct
- von ct, spiro
- ct-Arzneimittel Brand of Spironolactone
- ct Arzneimittel Brand of Spironolactone
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Below are MeSH descriptors whose meaning is more general than "Spironolactone".
Below are MeSH descriptors whose meaning is more specific than "Spironolactone".
This graph shows the total number of publications written about "Spironolactone" by people in this website by year, and whether "Spironolactone" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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2003 | 1 | 0 | 1 | 2006 | 0 | 1 | 1 | 2008 | 2 | 0 | 2 | 2009 | 2 | 1 | 3 | 2011 | 1 | 0 | 1 | 2013 | 1 | 0 | 1 | 2015 | 1 | 1 | 2 | 2016 | 1 | 0 | 1 | 2017 | 0 | 1 | 1 | 2018 | 0 | 1 | 1 | 2020 | 0 | 2 | 2 | 2021 | 1 | 1 | 2 | 2022 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Spironolactone" by people in Profiles.
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Cohen S, Sternlicht H, Bakris GL. Mineralocorticoid Receptor Antagonists in the Treatment of Diabetic Kidney Disease: Their Application in the Era of SGLT2 Inhibitors and GLP-1 Receptor Agonists. Curr Diab Rep. 2022 05; 22(5):213-218.
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Belkin MN, Blair JE, Shah SJ, Alenghat FJ. A composite metric for predicting benefit from spironolactone in heart failure with preserved ejection fraction. ESC Heart Fail. 2021 10; 8(5):3495-3503.
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Agarwal R, Kolkhof P, Bakris G, Bauersachs J, Haller H, Wada T, Zannad F. Steroidal and non-steroidal mineralocorticoid receptor antagonists in cardiorenal medicine. Eur Heart J. 2021 01 07; 42(2):152-161.
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Ali W, Bakris G. Evolution of Patiromer Use: a Review. Curr Cardiol Rep. 2020 07 09; 22(9):94.
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Bakris G, Yang YF, Pitt B. Mineralocorticoid Receptor Antagonists for Hypertension Management in Advanced Chronic Kidney Disease: BLOCK-CKD Trial. Hypertension. 2020 07; 76(1):144-149.
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Pitt B, Bakris GL, Weir MR, Freeman MW, Lainscak M, Mayo MR, Garza D, Zawadzki R, Berman L, Bushinsky DA. Long-term effects of patiromer for hyperkalaemia treatment in patients with mild heart failure and diabetic nephropathy on angiotensin-converting enzymes/angiotensin receptor blockers: results from AMETHYST-DN. ESC Heart Fail. 2018 08; 5(4):592-602.
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Dojki FK, Bakris G. Nonsteroidal mineralocorticoid antagonists in diabetic kidney disease. Curr Opin Nephrol Hypertens. 2017 09; 26(5):368-374.
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Rossignol P, Girerd N, Bakris G, Vardeny O, Claggett B, McMurray JJV, Swedberg K, Krum H, van Veldhuisen DJ, Shi H, Spanyers S, Vincent J, Fay R, Lamiral Z, Solomon SD, Zannad F, Pitt B. Impact of eplerenone on cardiovascular outcomes in heart failure patients with hypokalaemia. Eur J Heart Fail. 2017 06; 19(6):792-799.
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Sternlicht H, Bakris GL. Spironolactone for resistant hypertension--hard to resist? Lancet. 2015 Nov 21; 386(10008):2032-2034.
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Xu C, Tan S, Zhang J, Seubert CN, Gravenstein N, Sumners C, Vasilopoulos T, Martynyuk AE. Anesthesia with sevoflurane in neonatal rats: Developmental neuroendocrine abnormalities and alleviating effects of the corticosteroid and Cl(-) importer antagonists. Psychoneuroendocrinology. 2015 Oct; 60:173-81.
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