Farnesyl-Diphosphate Farnesyltransferase
"Farnesyl-Diphosphate Farnesyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it catalyzes the synthesis of SQUALENE from farnesyl pyrophosphate via the intermediate PRESQUALENE PYROPHOSPHATE. This enzyme is also a critical branch point enzyme in the biosynthesis of ISOPRENOIDS that is thought to regulate the flux of isoprene intermediates through the sterol pathway.
| Descriptor ID |
D013186
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| MeSH Number(s) |
D08.811.913.225.431
|
| Concept/Terms |
Farnesyl-Diphosphate Farnesyltransferase- Farnesyl-Diphosphate Farnesyltransferase
- Farnesyl Diphosphate Farnesyltransferase
- Farnesyltransferase, Farnesyl-Diphosphate
- FPP-FPP Farnesyl Transferase
- FPP FPP Farnesyl Transferase
- Farnesyl Transferase, FPP-FPP
- Transferase, FPP-FPP Farnesyl
- Squalene Synthase
- Synthase, Squalene
- Squalene Synthetase
- Synthetase, Squalene
- Farnesyldiphosphate-Farnesyldiphosphate Farnesyltransferase
- Farnesyldiphosphate Farnesyldiphosphate Farnesyltransferase
- Farnesyltransferase, Farnesyldiphosphate-Farnesyldiphosphate
- Presqualene-Diphosphate Synthase
- Presqualene Diphosphate Synthase
- Synthase, Presqualene-Diphosphate
|
Below are MeSH descriptors whose meaning is more general than "Farnesyl-Diphosphate Farnesyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Farnesyl-Diphosphate Farnesyltransferase".
This graph shows the total number of publications written about "Farnesyl-Diphosphate Farnesyltransferase" by people in this website by year, and whether "Farnesyl-Diphosphate Farnesyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
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Below are the most recent publications written about "Farnesyl-Diphosphate Farnesyltransferase" by people in Profiles.
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Lapaquistat acetate: development of a squalene synthase inhibitor for the treatment of hypercholesterolemia. Circulation. 2011 May 10; 123(18):1974-85.
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Squalene synthase inhibitor lapaquistat acetate: could anything be better than statins? Circulation. 2011 May 10; 123(18):1925-8.
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Golden pigment production and virulence gene expression are affected by metabolisms in Staphylococcus aureus. J Bacteriol. 2010 Jun; 192(12):3068-77.
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Other therapies for reducing low-density lipoprotein cholesterol: medications in development. Endocrinol Metab Clin North Am. 2009 Mar; 38(1):99-119.
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Novel nonstatin strategies to lower low-density lipoprotein cholesterol. Curr Atheroscler Rep. 2009 Jan; 11(1):67-70.
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Removing the golden coat of Staphylococcus aureus. N Engl J Med. 2008 Jul 03; 359(1):85-7.
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Squalene synthase inhibition: a novel target for the management of dyslipidemia. Curr Atheroscler Rep. 2007 Jan; 9(1):78-80.