GATA4 Transcription Factor
"GATA4 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A GATA transcription factor that is expressed in the MYOCARDIUM of developing heart and has been implicated in the differentiation of CARDIAC MYOCYTES. GATA4 is activated by PHOSPHORYLATION and regulates transcription of cardiac-specific genes.
| Descriptor ID |
D050991
|
| MeSH Number(s) |
D12.776.260.257.400 D12.776.930.314.400
|
| Concept/Terms |
GATA4 Transcription Factor- GATA4 Transcription Factor
- Transcription Factor, GATA4
- Transcription Factor GATA-4
- Factor GATA-4, Transcription
- GATA-4, Transcription Factor
- Transcription Factor GATA 4
- Transcription Factor GATA4
- Factor GATA4, Transcription
- GATA4, Transcription Factor
- GATA-4 Transcription Factor
- GATA 4 Transcription Factor
- Transcription Factor, GATA-4
|
Below are MeSH descriptors whose meaning is more general than "GATA4 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "GATA4 Transcription Factor".
This graph shows the total number of publications written about "GATA4 Transcription Factor" by people in this website by year, and whether "GATA4 Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2023 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "GATA4 Transcription Factor" by people in Profiles.
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A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network. Circulation. 2024 Apr 09; 149(15):1205-1230.
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GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology. Immunity. 2023 01 10; 56(1):43-57.e10.
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Noncanonical Notch signals have opposing roles during cardiac development. Biochem Biophys Res Commun. 2021 11 05; 577:12-16.
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Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development. PLoS Genet. 2019 05; 15(5):e1007711.
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Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):E1422-E1431.
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MiR-590 Promotes Transdifferentiation of Porcine and Human Fibroblasts Toward a Cardiomyocyte-Like Fate by Directly Repressing Specificity Protein 1. J Am Heart Assoc. 2016 11 10; 5(11).
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FOG-2 mediated recruitment of the NuRD complex regulates cardiomyocyte proliferation during heart development. Dev Biol. 2014 Nov 01; 395(1):50-61.
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Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected] Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4006-11.
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Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. Dev Biol. 2007 Jan 15; 301(2):602-14.
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Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4. Am J Physiol Heart Circ Physiol. 2006 May; 290(5):H1997-2006.