 Myostatin
"Myostatin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A growth differentiation factor that is a potent inhibitor of SKELETAL MUSCLE growth. It may play a role in the regulation of MYOGENESIS and in muscle maintenance during adulthood.
| Descriptor ID |
D055435
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| MeSH Number(s) |
D12.644.276.954.300.925 D12.776.467.942.300.925 D23.529.942.300.925
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| Concept/Terms |
Myostatin- Myostatin
- Growth Differentiation Factor 8
- GDF-8
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Below are MeSH descriptors whose meaning is more general than "Myostatin".
Below are MeSH descriptors whose meaning is more specific than "Myostatin".
This graph shows the total number of publications written about "Myostatin" by people in this website by year, and whether "Myostatin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2010 | 1 | 1 | 2 | | 2011 | 2 | 0 | 2 | | 2015 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Myostatin" by people in Profiles.
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Samant SA, Kanwal A, Pillai VB, Bao R, Gupta MP. The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy. Sci Rep. 2017 09 19; 7(1):11877.
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Lee YS, Lehar A, Sebald S, Liu M, Swaggart KA, Talbot CC, Pytel P, Barton ER, McNally EM, Lee SJ. Muscle hypertrophy induced by myostatin inhibition accelerates degeneration in dysferlinopathy. Hum Mol Genet. 2015 Oct 15; 24(20):5711-9.
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Qaisar R, Renaud G, Morine K, Barton ER, Sweeney HL, Larsson L. Is functional hypertrophy and specific force coupled with the addition of myonuclei at the single muscle fiber level? FASEB J. 2012 Mar; 26(3):1077-85.
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Bish LT, Sleeper MM, Forbes SC, Morine KJ, Reynolds C, Singletary GE, Trafny D, Pham J, Bogan J, Kornegay JN, Vandenborne K, Walter GA, Sweeney HL. Long-term systemic myostatin inhibition via liver-targeted gene transfer in golden retriever muscular dystrophy. Hum Gene Ther. 2011 Dec; 22(12):1499-509.
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Morine KJ, Bish LT, Selsby JT, Gazzara JA, Pendrak K, Sleeper MM, Barton ER, Lee SJ, Sweeney HL. Activin IIB receptor blockade attenuates dystrophic pathology in a mouse model of Duchenne muscular dystrophy. Muscle Nerve. 2010 Nov; 42(5):722-30.
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Morine KJ, Bish LT, Pendrak K, Sleeper MM, Barton ER, Sweeney HL. Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice. PLoS One. 2010 Feb 11; 5(2):e9176.
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Bogdanovich S, McNally EM, Khurana TS. Myostatin blockade improves function but not histopathology in a murine model of limb-girdle muscular dystrophy 2C. Muscle Nerve. 2008 Mar; 37(3):308-16.
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Parsons SA, Millay DP, Sargent MA, McNally EM, Molkentin JD. Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy. Am J Pathol. 2006 Jun; 168(6):1975-85.
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Sweeney HL. Gene doping. Sci Am. 2004 Jul; 291(1):62-9.
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McNally EM. Powerful genes--myostatin regulation of human muscle mass. N Engl J Med. 2004 Jun 24; 350(26):2642-4.
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