 Tryptophan Oxygenase
"Tryptophan Oxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN. It is a LIVER-specific enzyme that is the first and rate limiting enzyme in the kynurenine pathway of TRYPTOPHAN catabolism.
| Descriptor ID |
D014366
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| MeSH Number(s) |
D08.811.682.690.416.722
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| Concept/Terms |
Tryptophan Oxygenase- Tryptophan Oxygenase
- Oxygenase, Tryptophan
- Tryptophan 2,3-Dioxygenase
- 2,3-Dioxygenase, Tryptophan
- Tryptophan 2,3 Dioxygenase
- TDO Dioxygenase
- Dioxygenase, TDO
- Tryptophan Pyrrolase
- Pyrrolase, Tryptophan
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Below are MeSH descriptors whose meaning is more general than "Tryptophan Oxygenase".
Below are MeSH descriptors whose meaning is more specific than "Tryptophan Oxygenase".
This graph shows the total number of publications written about "Tryptophan Oxygenase" by people in this website by year, and whether "Tryptophan Oxygenase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tryptophan Oxygenase" by people in Profiles.
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Zhai L, Ladomersky E, Bell A, Dussold C, Cardoza K, Qian J, Lauing KL, Wainwright DA. Quantification of IDO1 enzyme activity in normal and malignant tissues. Methods Enzymol. 2019; 629:235-256.
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Zhai L, Spranger S, Binder DC, Gritsina G, Lauing KL, Giles FJ, Wainwright DA. Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy. Clin Cancer Res. 2015 Dec 15; 21(24):5427-33.
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Gajewski TF. Overcoming immune resistance in the tumor microenvironment by blockade of indoleamine 2,3-dioxygenase and programmed death ligand 1. Curr Opin Investig Drugs. 2004 Dec; 5(12):1279-83.
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Fallarino F, Grohmann U, Hwang KW, Orabona C, Vacca C, Bianchi R, Belladonna ML, Fioretti MC, Alegre ML, Puccetti P. Modulation of tryptophan catabolism by regulatory T cells. Nat Immunol. 2003 Dec; 4(12):1206-12.
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Miki T, Sun H, Lee Y, Tandin A, Kovscek AM, Subbotin V, Fung JJ, Valdivia LA. Blockade of tryptophan catabolism prevents spontaneous tolerogenicity of liver allografts. Transplant Proc. 2001 Feb-Mar; 33(1-2):129-30.
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