"AlkB Enzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of alpha- KETOGLUTARIC ACID and Fe(II)-dependent dioxygenases that are homologous to AlkB, an enzyme that repairs alkylated nucleic acids in E. coli. The mammalian homologs have diverse substrate specificities and functions that include DNA REPAIR, generating unique wobble modifications in URIDINE tRNA, demethylation of nucleotides in DNA and RNA, and demethylation of LYSINE residues on certain proteins, including ACTIN and histones (HISTONE CODE).
| Descriptor ID |
D000071496
|
| MeSH Number(s) |
D08.811.074.062 D08.811.682.690.416.139
|
| Concept/Terms |
AlkB Enzymes- AlkB Enzymes
- Enzymes, AlkB
- Alkylated DNA Repair Protein AlkB Homologs
- Alkylation Repair Homolog Proteins
- Alkylation Repair Homologs
- AlkB Homologs
|
Below are MeSH descriptors whose meaning is more general than "AlkB Enzymes".
Below are MeSH descriptors whose meaning is more specific than "AlkB Enzymes".
This graph shows the total number of publications written about "AlkB Enzymes" by people in this website by year, and whether "AlkB Enzymes" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "AlkB Enzymes" by people in Profiles.
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ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing. Nat Cell Biol. 2021 07; 23(7):684-691.
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Selective Enzymatic Demethylation of N2 ,N2 -Dimethylguanosine in RNA and Its Application in High-Throughput tRNA Sequencing. Angew Chem Int Ed Engl. 2017 04 24; 56(18):5017-5020.