"Dioxygenases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS.
| Descriptor ID |
D049308
|
| MeSH Number(s) |
D08.811.682.690.416
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Dioxygenases".
Below are MeSH descriptors whose meaning is more specific than "Dioxygenases".
This graph shows the total number of publications written about "Dioxygenases" by people in this website by year, and whether "Dioxygenases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 1 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 1 | 2 |
| 2010 | 2 | 1 | 3 |
| 2011 | 0 | 5 | 5 |
| 2012 | 2 | 2 | 4 |
| 2013 | 1 | 1 | 2 |
| 2014 | 2 | 3 | 5 |
| 2015 | 1 | 5 | 6 |
| 2016 | 0 | 2 | 2 |
| 2017 | 0 | 2 | 2 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 3 | 3 |
| 2020 | 1 | 2 | 3 |
| 2021 | 2 | 0 | 2 |
| 2022 | 2 | 0 | 2 |
| 2024 | 1 | 1 | 2 |
| 2025 | 0 | 2 | 2 |
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Below are the most recent publications written about "Dioxygenases" by people in Profiles.
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Tet Methylcytosine Dioxygenase 2 (TET2) Mutation Drives a Global Hypermethylation Signature in Patients With Pulmonary Arterial Hypertension (PAH): Correlation With Altered Gene Expression Relevant to a Common T Cell Phenotype. Compr Physiol. 2025 Apr; 15(2):e70011.
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TP53 mutations and TET2 deficiency cooperate to drive leukemogenesis and establish an immunosuppressive environment. J Clin Invest. 2025 May 15; 135(10).
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Genetic and environmental risks for clonal hematopoiesis and cancer. J Exp Med. 2025 Jan 06; 222(1).
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RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis. Nature. 2024 Oct; 634(8035):986-994.
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PU.1-Dependent Enhancer Inhibition Separates Tet2-Deficient Hematopoiesis from Malignant Transformation. Blood Cancer Discov. 2022 09 06; 3(5):444-467.
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Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis. Cell Host Microbe. 2022 07 13; 30(7):1003-1019.e10.
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TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors. Cancer Res. 2021 10 01; 81(19):5089-5101.
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TET2 Drives 5hmc Marking of GATA6 and Epigenetically Defines Pancreatic Ductal Adenocarcinoma Transcriptional Subtypes. Gastroenterology. 2021 08; 161(2):653-668.e16.
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Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2020 10; 586(7831):763-768.
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HIF-1 directly induces TET3 expression to enhance 5-hmC density and induce erythroid gene expression in hypoxia. Blood Adv. 2020 07 14; 4(13):3053-3062.