 Phorbol 12,13-Dibutyrate
"Phorbol 12,13-Dibutyrate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase C). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems.
| Descriptor ID |
D015240
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| MeSH Number(s) |
D02.455.849.291.500.510.700
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| Concept/Terms |
Phorbol 12,13-Dibutyrate- Phorbol 12,13-Dibutyrate
- 12,13-Dibutyrate, Phorbol
- Phorbol-12,13-Dibutyrate
- Phorbol 12,13 Dibutyrate
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Below are MeSH descriptors whose meaning is more general than "Phorbol 12,13-Dibutyrate".
Below are MeSH descriptors whose meaning is more specific than "Phorbol 12,13-Dibutyrate".
This graph shows the total number of publications written about "Phorbol 12,13-Dibutyrate" by people in this website by year, and whether "Phorbol 12,13-Dibutyrate" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1984 | 0 | 1 | 1 | | 1985 | 0 | 2 | 2 | | 1987 | 0 | 3 | 3 | | 1989 | 1 | 2 | 3 | | 1990 | 1 | 1 | 2 | | 1991 | 1 | 0 | 1 | | 1993 | 0 | 3 | 3 | | 1994 | 2 | 1 | 3 | | 1996 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 2 | 2 |
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Below are the most recent publications written about "Phorbol 12,13-Dibutyrate" by people in Profiles.
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Gomes I, Xiong W, Miki T, Rosner MR. A proline- and glutamine-rich protein promotes apoptosis in neuronal cells. J Neurochem. 1999 Aug; 73(2):612-22.
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Bhartur SG, Ballarin LJ, Musch MW, Bookstein C, Chang EB, Rao MC. A unique Na+/H+ exchanger, analogous to NHE1, in the chicken embryonic fibroblast. Am J Physiol. 1999 03; 276(3):R838-46.
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Dent G, Muñoz NM, Rühlmann E, Zhu X, Leff AR, Magnussen H, Rabe KF. Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils. Am J Respir Cell Mol Biol. 1998 Jan; 18(1):136-44.
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Morrison P, Saltiel AR, Rosner MR. Role of mitogen-activated protein kinase kinase in regulation of the epidermal growth factor receptor by protein kinase C. J Biol Chem. 1996 May 31; 271(22):12891-6.
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Lovinger DM, Merritt A, Reyes D. Involvement of N- and non-N-type calcium channels in synaptic transmission at corticostriatal synapses. Neuroscience. 1994 Sep; 62(1):31-40.
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Toskulkao C, Bhartur S, Musch MW, Chang EB, Rao MC. Phorbol dibutyrate-specific protein phosphorylation in brush border membranes of chicken enterocytes. J Cell Physiol. 1994 May; 159(2):347-55.
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Chao TS, Foster DA, Rapp UR, Rosner MR. Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium. J Biol Chem. 1994 Mar 11; 269(10):7337-41.
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da Cruz e Silva OA, Iverfeldt K, Oltersdorf T, Sinha S, Lieberburg I, Ramabhadran TV, Suzuki T, Sisodia SS, Gandy S, Greengard P. Regulated cleavage of Alzheimer beta-amyloid precursor protein in the absence of the cytoplasmic tail. Neuroscience. 1993 Dec; 57(4):873-7.
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Morrison P, Takishima K, Rosner MR. Role of threonine residues in regulation of the epidermal growth factor receptor by protein kinase C and mitogen-activated protein kinase. J Biol Chem. 1993 Jul 25; 268(21):15536-43.
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Swartz KJ, Merritt A, Bean BP, Lovinger DM. Protein kinase C modulates glutamate receptor inhibition of Ca2+ channels and synaptic transmission. Nature. 1993 Jan 14; 361(6408):165-8.
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