DNA-(Apurinic or Apyrimidinic Site) Lyase
"DNA-(Apurinic or Apyrimidinic Site) Lyase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.
| Descriptor ID |
D043603
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| MeSH Number(s) |
D08.811.074.750 D08.811.520.241.225
|
| Concept/Terms |
DNA-(Apurinic or Apyrimidinic Site) Lyase- DNA-(Apurinic or Apyrimidinic Site) Lyase
- AP Endonuclease
- Endonuclease, AP
- Endodeoxyribonuclease (Apurinic or Apyrimidinic)
- Apurine-Apyrimidine Endonuclease
- Apurine Apyrimidine Endonuclease
- Endonuclease, Apurine-Apyrimidine
- Apurinic DNA Endonuclease
- DNA Endonuclease, Apurinic
- Endonuclease, Apurinic DNA
- Apurinic Endonuclease
- Endonuclease, Apurinic
- DNA Lyase (Apurinic or Apyrimidinic)
- AP Lyase
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Below are MeSH descriptors whose meaning is more general than "DNA-(Apurinic or Apyrimidinic Site) Lyase".
Below are MeSH descriptors whose meaning is more specific than "DNA-(Apurinic or Apyrimidinic Site) Lyase".
This graph shows the total number of publications written about "DNA-(Apurinic or Apyrimidinic Site) Lyase" by people in this website by year, and whether "DNA-(Apurinic or Apyrimidinic Site) Lyase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA-(Apurinic or Apyrimidinic Site) Lyase" by people in Profiles.
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Structure of human apurinic/apyrimidinic endonuclease 1 with the essential Mg2+ cofactor. Acta Crystallogr D Biol Crystallogr. 2013 Dec; 69(Pt 12):2555-62.
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Coordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions. DNA Repair (Amst). 2013 Dec; 12(12):1043-52.
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Functional assessment of population and tumor-associated APE1 protein variants. PLoS One. 2013; 8(6):e65922.
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NMR studies reveal an unexpected binding site for a redox inhibitor of AP endonuclease 1. Biochemistry. 2011 Dec 06; 50(48):10540-9.
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Part II. Initial molecular and cellular characterization of high nitric oxide-adapted human tongue squamous cell carcinoma cell lines. Tumour Biol. 2011 Feb; 32(1):87-98.
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Chemical shift assignments for human apurinic/apyrimidinic endonuclease 1. Biomol NMR Assign. 2010 Apr; 4(1):5-8.
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The RAS-dependent ERF control of cell proliferation and differentiation is mediated by c-Myc repression. J Biol Chem. 2007 Oct 12; 282(41):30285-94.
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Positive control of a global antioxidant defense regulon activated by superoxide-generating agents in Escherichia coli. Proc Natl Acad Sci U S A. 1990 Aug; 87(16):6181-5.
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A global response induced in Escherichia coli by redox-cycling agents overlaps with that induced by peroxide stress. J Bacteriol. 1989 Jul; 171(7):3933-9.