Penicillin-Binding Proteins

"Penicillin-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Bacterial proteins that share the property of binding irreversibly to PENICILLINS and other ANTIBACTERIAL AGENTS derived from LACTAMS. The penicillin-binding proteins are primarily enzymes involved in CELL WALL biosynthesis including MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PEPTIDE SYNTHASES; TRANSPEPTIDASES; and HEXOSYLTRANSFERASES.

Descriptor ID	D046915
MeSH Number(s)	D08.811.710 D12.776.097.545
Concept/Terms	Penicillin-Binding Proteins Penicillin-Binding Proteins Penicillin Binding Proteins Proteins, Penicillin-Binding Penicillin-Binding Protein Penicillin Binding Protein Penicillin-Binding Protein 1A Penicillin-Binding Protein 1A Penicillin Binding Protein 1A Protein 1A, Penicillin-Binding Penicillin-Binding Protein 1b Penicillin-Binding Protein 1b Penicillin Binding Protein 1b Protein 1b, Penicillin-Binding Penicillin-Binding Protein 2 Penicillin-Binding Protein 2 Penicillin Binding Protein 2 Penicillin-Binding Protein 2a Penicillin-Binding Protein 2a Penicillin Binding Protein 2a Penicillin-Binding Protein-2a Peptidoglycan Synthetase Peptidoglycan Synthetase Synthetase, Peptidoglycan Penicillin-Binding Protein 3 Penicillin-Binding Protein 3 Penicillin Binding Protein 3 Penicillin-Binding Protein 4 Penicillin-Binding Protein 4 Penicillin Binding Protein 4 Penicillin-Binding Protein 5 Penicillin-Binding Protein 5 Penicillin Binding Protein 5 Penicillin-Binding Protein 6 Penicillin-Binding Protein 6 Penicillin Binding Protein 6 Penicillin-Binding Protein 7 Penicillin-Binding Protein 7 Penicillin Binding Protein 7 Penicillin-Binding Protein 1 Penicillin-Binding Protein 1 Penicillin Binding Protein 1 Penicillin-Binding Protein 2b Penicillin-Binding Protein 2b Penicillin Binding Protein 2b

Below are MeSH descriptors whose meaning is more general than "Penicillin-Binding Proteins".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Penicillin-Binding Proteins [D08.811.710]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Bacterial Proteins [D12.776.097]
Penicillin-Binding Proteins [D12.776.097.545]

Below are MeSH descriptors whose meaning is related to "Penicillin-Binding Proteins".

Below are MeSH descriptors whose meaning is more specific than "Penicillin-Binding Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Penicillin-Binding Proteins" by people in this website by year, and whether "Penicillin-Binding Proteins" was a major or minor topic of these publications.

Bar chart showing 3 publications over 3 distinct years, with a maximum of 1 publications in 1985 and 1995 and 2018

To see the data from this visualization as text, click here.

Below are the most recent publications written about "Penicillin-Binding Proteins" by people in Profiles.

Kociolek LK, Ozer EA, Gerding DN, Hecht DW, Patel SJ, Hauser AR. Whole-genome analysis reveals the evolution and transmission of an MDR DH/NAP11/106 Clostridium difficile clone in a paediatric hospital. J Antimicrob Chemother. 2018 05 01; 73(5):1222-1229.

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Schneewind O. Classic Spotlight: Molecular Biology of Methicillin Resistance in Staphylococcus aureus. J Bacteriol. 2016 07 15; 198(14):1903.

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Ito T, Hiramatsu K, Tomasz A, de Lencastre H, Perreten V, Holden MT, Coleman DC, Goering R, Giffard PM, Skov RL, Zhang K, Westh H, O'Brien F, Tenover FC, Oliveira DC, Boyle-Vavra S, Laurent F, Kearns AM, Kreiswirth B, Ko KS, Grundmann H, Sollid JE, John JF, Daum R, Soderquist B, Buist G. Guidelines for reporting novel mecA gene homologues. Antimicrob Agents Chemother. 2012 Oct; 56(10):4997-9.

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Boyle-Vavra S, Yin S, Daum RS. The VraS/VraR two-component regulatory system required for oxacillin resistance in community-acquired methicillin-resistant Staphylococcus aureus. FEMS Microbiol Lett. 2006 Sep; 262(2):163-71.

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Yin S, Daum RS, Boyle-Vavra S. VraSR two-component regulatory system and its role in induction of pbp2 and vraSR expression by cell wall antimicrobials in Staphylococcus aureus. Antimicrob Agents Chemother. 2006 Jan; 50(1):336-43.

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Mongkolrattanothai K, Boyle S, Murphy TV, Daum RS. Novel non-mecA-containing staphylococcal chromosomal cassette composite island containing pbp4 and tagF genes in a commensal staphylococcal species: a possible reservoir for antibiotic resistance islands in Staphylococcus aureus. Antimicrob Agents Chemother. 2004 May; 48(5):1823-36.

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Boyle-Vavra S, Yin S, Challapalli M, Daum RS. Transcriptional induction of the penicillin-binding protein 2 gene in Staphylococcus aureus by cell wall-active antibiotics oxacillin and vancomycin. Antimicrob Agents Chemother. 2003 Mar; 47(3):1028-36.

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Hanaki H, Kuwahara-Arai K, Boyle-Vavra S, Daum RS, Labischinski H, Hiramatsu K. Activated cell-wall synthesis is associated with vancomycin resistance in methicillin-resistant Staphylococcus aureus clinical strains Mu3 and Mu50. J Antimicrob Chemother. 1998 Aug; 42(2):199-209.

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Moreira B, Boyle-Vavra S, deJonge BL, Daum RS. Increased production of penicillin-binding protein 2, increased detection of other penicillin-binding proteins, and decreased coagulase activity associated with glycopeptide resistance in Staphylococcus aureus. Antimicrob Agents Chemother. 1997 Aug; 41(8):1788-93.

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Fasola EL, Fasching CE, Peterson LR. Molecular correlation between in vitro and in vivo activity of beta-lactam and beta-lactamase inhibitor combinations against methicillin-resistant Staphylococcus aureus. J Lab Clin Med. 1995 Feb; 125(2):200-11.

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