"DNA Gyrase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits. In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase.
| Descriptor ID |
D027081
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| MeSH Number(s) |
D08.811.399.403.741.149 D12.776.097.237
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "DNA Gyrase".
Below are MeSH descriptors whose meaning is more specific than "DNA Gyrase".
This graph shows the total number of publications written about "DNA Gyrase" by people in this website by year, and whether "DNA Gyrase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA Gyrase" by people in Profiles.
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Whole-genome analysis reveals the evolution and transmission of an MDR DH/NAP11/106 Clostridium difficile clone in a paediatric hospital. J Antimicrob Chemother. 2018 05 01; 73(5):1222-1229.
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Abrupt emergence of a single dominant multidrug-resistant strain of Escherichia coli. J Infect Dis. 2013 Mar 15; 207(6):919-28.
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Acceleration of emergence of bacterial antibiotic resistance in connected microenvironments. Science. 2011 Sep 23; 333(6050):1764-7.
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Role of the extended alpha4 domain of Staphylococcus aureus gyrase A protein in determining low sensitivity to quinolones. Antimicrob Agents Chemother. 2006 Feb; 50(2):600-6.
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A superhelical spiral in the Escherichia coli DNA gyrase A C-terminal domain imparts unidirectional supercoiling bias. J Biol Chem. 2005 Jul 15; 280(28):26177-84.
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Contribution of topoisomerase IV and DNA gyrase mutations in Streptococcus pneumoniae to resistance to novel fluoroquinolones. Antimicrob Agents Chemother. 1999 Aug; 43(8):2000-4.
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GyrA sequence analysis of Staphylococcus aureus and methicillin-resistant S. aureus strains selected, in vitro, for high-level ciprofloxacin resistance. Diagn Microbiol Infect Dis. 1993 Aug-Sep; 17(2):97-101.