 Transient Receptor Potential Channels
"Transient Receptor Potential Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN repeats are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.
| Descriptor ID |
D050051
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| MeSH Number(s) |
D12.776.157.530.400.901 D12.776.543.585.400.901
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| Concept/Terms |
Transient Receptor Potential Channels- Transient Receptor Potential Channels
- TRP Membrane Proteins
- Membrane Proteins, TRP
- Proteins, TRP Membrane
- TRP Cation Channels
- Cation Channels, TRP
- Channels, TRP Cation
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Below are MeSH descriptors whose meaning is more general than "Transient Receptor Potential Channels".
Below are MeSH descriptors whose meaning is more specific than "Transient Receptor Potential Channels".
This graph shows the total number of publications written about "Transient Receptor Potential Channels" by people in this website by year, and whether "Transient Receptor Potential Channels" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 1 | 2 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 1 | 2 | | 2013 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Transient Receptor Potential Channels" by people in Profiles.
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Miao Y, Li G, Zhang X, Xu H, Abraham SN. A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion. Cell. 2015 Jun 04; 161(6):1306-19.
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Schwartz ES, La JH, Scheff NN, Davis BM, Albers KM, Gebhart GF. TRPV1 and TRPA1 antagonists prevent the transition of acute to chronic inflammation and pain in chronic pancreatitis. J Neurosci. 2013 Mar 27; 33(13):5603-11.
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Malin S, Molliver D, Christianson JA, Schwartz ES, Cornuet P, Albers KM, Davis BM. TRPV1 and TRPA1 function and modulation are target tissue dependent. J Neurosci. 2011 Jul 20; 31(29):10516-28.
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Mrejeru A, Wei A, Ramirez JM. Calcium-activated non-selective cation currents are involved in generation of tonic and bursting activity in dopamine neurons of the substantia nigra pars compacta. J Physiol. 2011 May 15; 589(Pt 10):2497-514.
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Schwartz ES, Christianson JA, Chen X, La JH, Davis BM, Albers KM, Gebhart GF. Synergistic role of TRPV1 and TRPA1 in pancreatic pain and inflammation. Gastroenterology. 2011 Apr; 140(4):1283-1291.e1-2.
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Zhu X, Learoyd J, Butt S, Zhu L, Usatyuk PV, Natarajan V, Munoz NM, Leff AR. Regulation of eosinophil adhesion by lysophosphatidylcholine via a non-store-operated Ca2+ channel. Am J Respir Cell Mol Biol. 2007 May; 36(5):585-93.
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Jacobson DA, Philipson LH. TRP channels of the pancreatic beta cell. Handb Exp Pharmacol. 2007; (179):409-24.
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