 Somatic Hypermutation, Immunoglobulin
"Somatic Hypermutation, Immunoglobulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A programmed mutation process whereby changes are introduced to the nucleotide sequence of immunoglobulin gene DNA during development.
| Descriptor ID |
D027041
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| MeSH Number(s) |
G05.355.600.810 G12.425.742.765 G12.500.349.765
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| Concept/Terms |
Somatic Hypermutation, Immunoglobulin- Somatic Hypermutation, Immunoglobulin
- Hypermutation, Immunoglobulin Somatic
- Hypermutations, Immunoglobulin Somatic
- Immunoglobulin Somatic Hypermutations
- Somatic Hypermutations, Immunoglobulin
- Ig Somatic Hypermutation
- Immunoglobulin Somatic Hypermutation
- Hypermutation, Somatic, Immunoglobulin
- Somatic Hypermutation, Ig
- Hypermutation, Ig Somatic
- Hypermutations, Ig Somatic
- Ig Somatic Hypermutations
- Somatic Hypermutations, Ig
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Below are MeSH descriptors whose meaning is more general than "Somatic Hypermutation, Immunoglobulin".
Below are MeSH descriptors whose meaning is more specific than "Somatic Hypermutation, Immunoglobulin".
This graph shows the total number of publications written about "Somatic Hypermutation, Immunoglobulin" by people in this website by year, and whether "Somatic Hypermutation, Immunoglobulin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2002 | 2 | 0 | 2 | | 2003 | 3 | 0 | 3 | | 2005 | 2 | 1 | 3 | | 2006 | 1 | 0 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 1 | 2 | | 2009 | 1 | 1 | 2 | | 2010 | 2 | 0 | 2 | | 2011 | 1 | 1 | 2 | | 2012 | 1 | 1 | 2 | | 2013 | 1 | 1 | 2 | | 2014 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Somatic Hypermutation, Immunoglobulin" by people in Profiles.
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Guthmiller JJ, Lan LY, Fernández-Quintero ML, Han J, Utset HA, Bitar DJ, Hamel NJ, Stovicek O, Li L, Tepora M, Henry C, Neu KE, Dugan HL, Borowska MT, Chen YQ, Liu STH, Stamper CT, Zheng NY, Huang M, Palm AE, García-Sastre A, Nachbagauer R, Palese P, Coughlan L, Krammer F, Ward AB, Liedl KR, Wilson PC. Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses. Immunity. 2020 12 15; 53(6):1230-1244.e5.
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Cobey S, Wilson P, Matsen FA. The evolution within us. Philos Trans R Soc Lond B Biol Sci. 2015 Sep 05; 370(1676).
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Storb U. Why does somatic hypermutation by AID require transcription of its target genes? Adv Immunol. 2014; 122:253-77.
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Kodgire P, Mukkawar P, Ratnam S, Martin TE, Storb U. Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID. J Exp Med. 2013 Jul 01; 210(7):1481-92.
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Jiang N, He J, Weinstein JA, Penland L, Sasaki S, He XS, Dekker CL, Zheng NY, Huang M, Sullivan M, Wilson PC, Greenberg HB, Davis MM, Fisher DS, Quake SR. Lineage structure of the human antibody repertoire in response to influenza vaccination. Sci Transl Med. 2013 Feb 06; 5(171):171ra19.
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Kodgire P, Mukkawar P, North JA, Poirier MG, Storb U. Nucleosome stability dramatically impacts the targeting of somatic hypermutation. Mol Cell Biol. 2012 May; 32(10):2030-40.
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Di Niro R, Mesin L, Zheng NY, Stamnaes J, Morrissey M, Lee JH, Huang M, Iversen R, du Pré MF, Qiao SW, Lundin KE, Wilson PC, Sollid LM. High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions. Nat Med. 2012 Feb 26; 18(3):441-5.
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Meng W, Yunk L, Wang LS, Maganty A, Xue E, Cohen PL, Eisenberg RA, Weigert MG, Mancini SJ, Prak ET. Selection of individual VH genes occurs at the pro-B to pre-B cell transition. J Immunol. 2011 Aug 15; 187(4):1835-44.
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Sciammas R, Li Y, Warmflash A, Song Y, Dinner AR, Singh H. An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling. Mol Syst Biol. 2011 May 24; 7:495.
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Ratnam S, Bozek G, Nicolae D, Storb U. The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated. Mol Immunol. 2010 Oct; 47(16):2611-8.
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