Core Binding Factor Alpha 2 Subunit
"Core Binding Factor Alpha 2 Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.
| Descriptor ID |
D050676
|
| MeSH Number(s) |
D12.776.930.155.200.200
|
| Concept/Terms |
Core Binding Factor Alpha 2 Subunit- Core Binding Factor Alpha 2 Subunit
- Runx1 Protein
- Pebp2a2 Protein
- Runt-Related Transcription Factor 1
- Runt Related Transcription Factor 1
- Acute Myeloid Leukemia 1 Protein
- Core-Binding Factor Alpha 2 Protein
- Core Binding Factor Alpha 2 Protein
|
Below are MeSH descriptors whose meaning is more general than "Core Binding Factor Alpha 2 Subunit".
Below are MeSH descriptors whose meaning is more specific than "Core Binding Factor Alpha 2 Subunit".
This graph shows the total number of publications written about "Core Binding Factor Alpha 2 Subunit" by people in this website by year, and whether "Core Binding Factor Alpha 2 Subunit" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 4 | 4 |
| 2005 | 0 | 2 | 2 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 2 | 3 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 2 | 0 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 2 | 2 |
| 2017 | 2 | 0 | 2 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 2 | 3 |
| 2020 | 1 | 1 | 2 |
| 2021 | 1 | 1 | 2 |
| 2022 | 1 | 2 | 3 |
| 2023 | 1 | 4 | 5 |
| 2024 | 1 | 1 | 2 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Core Binding Factor Alpha 2 Subunit" by people in Profiles.
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Targeting the CD74 signaling axis suppresses inflammation and rescues defective hematopoiesis in RUNX1-familial platelet disorder. Sci Transl Med. 2025 Jan 08; 17(780):eadn9832.
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Germ line ERG haploinsufficiency defines a new syndrome with cytopenia and hematological malignancy predisposition. Blood. 2024 10 24; 144(17):1765-1780.
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PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape. Nat Immunol. 2024 May; 25(5):860-872.
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Natural history study of patients with familial platelet disorder with associated myeloid malignancy. Blood. 2023 12 21; 142(25):2146-2158.
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Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41. Blood Adv. 2023 10 24; 7(20):6092-6107.
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S1P-S1PR3-RAS promotes the progression of S1PR3hi TAL1+ T-cell acute lymphoblastic leukemia that can be effectively inhibited by an S1PR3 antagonist. Leukemia. 2023 10; 37(10):1982-1993.
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ABL1 kinase as a tumor suppressor in AML1-ETO and NUP98-PMX1 leukemias. Blood Cancer J. 2023 03 23; 13(1):42.
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A RUNX1-FPDMM rhesus macaque model reproduces the human phenotype and predicts challenges to curative gene therapies. Blood. 2023 01 19; 141(3):231-237.
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HOXA9 has the hallmarks of a biological switch with implications in blood cancers. Nat Commun. 2022 10 03; 13(1):5829.
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Revision of RUNX1 variant curation rules. Blood Adv. 2022 08 23; 6(16):4726-4730.