"Germ-Line Mutation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not.
| Descriptor ID |
D018095
|
| MeSH Number(s) |
G05.365.590.350
|
| Concept/Terms |
Germ-Line Mutation- Germ-Line Mutation
- Germ Line Mutation
- Germline Mutation
- Germline Mutations
- Mutation, Germline
- Mutations, Germline
- Mutation, Germ-Line
- Germ-Line Mutations
- Mutation, Germ Line
- Mutations, Germ-Line
|
Below are MeSH descriptors whose meaning is more general than "Germ-Line Mutation".
Below are MeSH descriptors whose meaning is more specific than "Germ-Line Mutation".
This graph shows the total number of publications written about "Germ-Line Mutation" by people in this website by year, and whether "Germ-Line Mutation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 2000 | 4 | 1 | 5 |
| 2001 | 3 | 1 | 4 |
| 2002 | 1 | 1 | 2 |
| 2003 | 0 | 2 | 2 |
| 2004 | 4 | 2 | 6 |
| 2005 | 2 | 2 | 4 |
| 2006 | 1 | 3 | 4 |
| 2007 | 0 | 3 | 3 |
| 2008 | 2 | 1 | 3 |
| 2009 | 0 | 3 | 3 |
| 2010 | 1 | 2 | 3 |
| 2011 | 7 | 2 | 9 |
| 2012 | 2 | 5 | 7 |
| 2013 | 2 | 3 | 5 |
| 2014 | 5 | 5 | 10 |
| 2015 | 8 | 7 | 15 |
| 2016 | 6 | 2 | 8 |
| 2017 | 5 | 7 | 12 |
| 2018 | 7 | 11 | 18 |
| 2019 | 16 | 9 | 25 |
| 2020 | 14 | 8 | 22 |
| 2021 | 12 | 10 | 22 |
| 2022 | 5 | 10 | 15 |
| 2023 | 1 | 11 | 12 |
| 2024 | 9 | 3 | 12 |
| 2025 | 1 | 1 | 2 |
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click here.
Below are the most recent publications written about "Germ-Line Mutation" by people in Profiles.
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Germline and Somatic Genomic Testing for Metastatic Prostate Cancer: ASCO Guideline. J Clin Oncol. 2025 Feb 20; 43(6):748-758.
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Pathogenic Variants in Cancer Susceptibility Genes Predispose to Ductal Carcinoma In Situ of the Breast. Clin Cancer Res. 2025 Jan 06; 31(1):130-138.
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Diagnostic Challenges due to a Germline Missense MSH2 Variant in a Patient With Immunotherapy-Responsive Locally Advanced Rectal Adenocarcinoma. Cancer Rep (Hoboken). 2024 Dec; 7(12):e70037.
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Gene-based burden tests of rare germline variants identify six cancer susceptibility genes. Nat Genet. 2024 Nov; 56(11):2422-2433.
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Germ line ERG haploinsufficiency defines a new syndrome with cytopenia and hematological malignancy predisposition. Blood. 2024 10 24; 144(17):1765-1780.
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Germline CDH1 Variants and Lifetime Cancer Risk. JAMA. 2024 09 03; 332(9):722-729.
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Association of ESR1 Germline Variants with TP53 Somatic Variants in Breast Tumors in a Genome-wide Study. Cancer Res Commun. 2024 06 27; 4(6):1597-1608.
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The clock-like accumulation of germline and somatic mutations can arise from the interplay of DNA damage and repair. PLoS Biol. 2024 Jun; 22(6):e3002678.
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Germline Predisposition in Hematologic Malignancies: Testing, Management, and Implications. Am Soc Clin Oncol Educ Book. 2024 Jun; 44(3):e432218.
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Myeloid neoplasms in individuals with breast and ovarian cancer and the association with deleterious germline variants. Gynecol Oncol. 2024 08; 187:235-240.