"Germ-Line Mutation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not.
Descriptor ID |
D018095
|
MeSH Number(s) |
G05.365.590.350
|
Concept/Terms |
Germ-Line Mutation- Germ-Line Mutation
- Germ Line Mutation
- Germline Mutation
- Germline Mutations
- Mutation, Germline
- Mutations, Germline
- Mutation, Germ-Line
- Germ-Line Mutations
- Mutation, Germ Line
- Mutations, Germ-Line
|
Below are MeSH descriptors whose meaning is more general than "Germ-Line Mutation".
Below are MeSH descriptors whose meaning is more specific than "Germ-Line Mutation".
This graph shows the total number of publications written about "Germ-Line Mutation" by people in this website by year, and whether "Germ-Line Mutation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1996 | 1 | 0 | 1 |
1998 | 1 | 0 | 1 |
2000 | 4 | 1 | 5 |
2001 | 3 | 1 | 4 |
2002 | 1 | 1 | 2 |
2003 | 0 | 2 | 2 |
2004 | 4 | 2 | 6 |
2005 | 2 | 2 | 4 |
2006 | 1 | 2 | 3 |
2007 | 0 | 3 | 3 |
2008 | 2 | 1 | 3 |
2009 | 0 | 3 | 3 |
2010 | 1 | 2 | 3 |
2011 | 7 | 2 | 9 |
2012 | 2 | 5 | 7 |
2013 | 2 | 3 | 5 |
2014 | 5 | 5 | 10 |
2015 | 8 | 7 | 15 |
2016 | 6 | 2 | 8 |
2017 | 5 | 7 | 12 |
2018 | 7 | 11 | 18 |
2019 | 16 | 9 | 25 |
2020 | 14 | 8 | 22 |
2021 | 12 | 9 | 21 |
2022 | 5 | 10 | 15 |
2023 | 2 | 9 | 11 |
2024 | 0 | 3 | 3 |
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Below are the most recent publications written about "Germ-Line Mutation" by people in Profiles.
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Insights into the Molecular Mechanisms of Genetic Predisposition to Hematopoietic Malignancies: The Importance of Gene-Environment Interactions. Cancer Discov. 2024 Mar 01; 14(3):396-405.
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Germline predisposition to myeloid neoplasms: Characteristics and management of high versus variable penetrance disorders. Best Pract Res Clin Haematol. 2024 Mar; 37(1):101537.
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Germline loss-of-function BRCA1 and BRCA2 mutations and risk of de novo hematopoietic malignancies. Haematologica. 2024 Jan 01; 109(1):351-356.
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Sequential tumor molecular profiling identifies likely germline variants. Genet Med. 2024 Mar; 26(3):101037.
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Impact of genetic counseling strategy on diagnostic yield and workload for genome-sequencing-based tumor diagnostics. Genet Med. 2024 Feb; 26(2):101032.
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PROMISE Registry: A prostate cancer registry of outcomes and germline mutations for improved survival and treatment effectiveness. Prostate. 2024 Feb; 84(3):292-302.
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Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41. Blood Adv. 2023 10 24; 7(20):6092-6107.
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Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival. Cancer Med. 2023 08; 12(15):16142-16162.
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Surgical phenotype of patients with peritoneal mesothelioma and a germline mutation. Cancer. 2023 07 15; 129(14):2152-2160.
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DDX41-associated susceptibility to myeloid neoplasms. Blood. 2023 03 30; 141(13):1544-1552.