"Germ-Line Mutation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not.
| Descriptor ID |
D018095
|
| MeSH Number(s) |
G05.365.590.350
|
| Concept/Terms |
Germ-Line Mutation- Germ-Line Mutation
- Germ Line Mutation
- Germline Mutation
- Germline Mutations
- Mutation, Germline
- Mutations, Germline
- Mutation, Germ-Line
- Germ-Line Mutations
- Mutation, Germ Line
- Mutations, Germ-Line
|
Below are MeSH descriptors whose meaning is more general than "Germ-Line Mutation".
Below are MeSH descriptors whose meaning is more specific than "Germ-Line Mutation".
This graph shows the total number of publications written about "Germ-Line Mutation" by people in this website by year, and whether "Germ-Line Mutation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 2000 | 4 | 1 | 5 |
| 2001 | 3 | 1 | 4 |
| 2002 | 1 | 1 | 2 |
| 2003 | 0 | 2 | 2 |
| 2004 | 4 | 2 | 6 |
| 2005 | 2 | 2 | 4 |
| 2006 | 1 | 3 | 4 |
| 2007 | 0 | 3 | 3 |
| 2008 | 2 | 1 | 3 |
| 2009 | 0 | 3 | 3 |
| 2010 | 1 | 2 | 3 |
| 2011 | 7 | 2 | 9 |
| 2012 | 2 | 5 | 7 |
| 2013 | 2 | 3 | 5 |
| 2014 | 5 | 5 | 10 |
| 2015 | 8 | 7 | 15 |
| 2016 | 6 | 2 | 8 |
| 2017 | 6 | 7 | 13 |
| 2018 | 8 | 11 | 19 |
| 2019 | 17 | 10 | 27 |
| 2020 | 15 | 8 | 23 |
| 2021 | 12 | 10 | 22 |
| 2022 | 6 | 10 | 16 |
| 2023 | 1 | 11 | 12 |
| 2024 | 9 | 3 | 12 |
| 2025 | 13 | 9 | 22 |
| 2026 | 8 | 3 | 11 |
To return to the timeline,
click here.
Below are the most recent publications written about "Germ-Line Mutation" by people in Profiles.
-
Functional analysis of germline RUNX1 variants identified in individuals with suspected familial platelet disorder. Blood Adv. 2026 Oct 13; 10(19):6407-6421.
-
Germline and somatic variants in DNMT3A and other clonal haematopoiesis of indeterminate potential genes contribute to pulmonary arterial hypertension. Eur Heart J. 2026 Sep 02; 47(33):4658-4675.
-
Sex differences in transcription-associated mutagenesis in the human germline. Genetics. 2026 08 05; 233(4).
-
The Role of "Adult-Onset" Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review. Pediatr Blood Cancer. 2026 Sep; 73(9):e70465.
-
What sets the mutation rate of a cell type in an animal species? PLoS Biol. 2026 Jun; 24(6):e3003799.
-
The Genetics and Screening of Gastroenteropancreatic Neuroendocrine Tumors and Adrenal Tumors. Surg Clin North Am. 2026 Aug; 106(4):555-569.
-
Real-world genetic testing data of ovarian cancer patients: Informing counseling and risk reduction in patients over age seventy. Gynecol Oncol. 2026 06; 209:77-87.
-
Germline genetic testing and privacy concerns in patients with mesothelioma. Genet Med. 2026 05; 28(5):102550.
-
Refinement of the classification of DDX41 variants through analysis of aggregated clinical datasets. Leukemia. 2026 Mar; 40(3):649-660.
-
Generation of an induced pluripotent stem cell line CGOi001-A from a patient with hereditary thrombocytopenia and a germline ANKRD26 mutation. Stem Cell Res. 2026 Mar; 91:103919.