Actin-Related Protein 2-3 Complex
"Actin-Related Protein 2-3 Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments.
| Descriptor ID |
D051376
|
| MeSH Number(s) |
D05.750.078.730.246 D12.776.220.525.246
|
| Concept/Terms |
Actin-Related Protein 2-3 Complex- Actin-Related Protein 2-3 Complex
- Actin Related Protein 2 3 Complex
- Arp2-3 Complex
- Arp2 3 Complex
- Arp2-3 Protein Complex
- Arp2 3 Protein Complex
|
Below are MeSH descriptors whose meaning is more general than "Actin-Related Protein 2-3 Complex".
Below are MeSH descriptors whose meaning is more specific than "Actin-Related Protein 2-3 Complex".
This graph shows the total number of publications written about "Actin-Related Protein 2-3 Complex" by people in this website by year, and whether "Actin-Related Protein 2-3 Complex" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2014 | 4 | 0 | 4 |
| 2018 | 2 | 1 | 3 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Actin-Related Protein 2-3 Complex" by people in Profiles.
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Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance. Nat Cell Biol. 2022 02; 24(2):168-180.
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Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein. Nat Cell Biol. 2020 06; 22(6):674-688.
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Feeling the force: formin's role in mechanotransduction. Curr Opin Cell Biol. 2019 02; 56:130-140.
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Biallelic loss of human CTNNA2, encoding aN-catenin, leads to ARP2/3 complex overactivity and disordered cortical neuronal migration. Nat Genet. 2018 08; 50(8):1093-1101.
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Actin Cross-Linking Toxin Is a Universal Inhibitor of Tandem-Organized and Oligomeric G-Actin Binding Proteins. Curr Biol. 2018 05 21; 28(10):1536-1547.e9.
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Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination. Nat Commun. 2018 03 13; 9(1):1053.
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Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex. Dev Cell. 2015 Jan 12; 32(1):43-53.
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Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways. Dev Cell. 2015 Jan 12; 32(1):54-67.
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Arp2/3 inhibition induces amoeboid-like protrusions in MCF10A epithelial cells by reduced cytoskeletal-membrane coupling and focal adhesion assembly. PLoS One. 2014; 9(6):e100943.
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Homeostatic actin cytoskeleton networks are regulated by assembly factor competition for monomers. Curr Biol. 2014 Mar 03; 24(5):579-85.