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Anning Lin

TitleProfessor
InstitutionUniversity of Chicago
DepartmentBen May Department of Cancer Research
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Signaling mechanism in inflammation, cancer and neuronal degenerative disease

    My laboratory has a long-standing interest in understanding how the intracellular signaling network is integrated in response to a variety of extracellular signals, thereby controlling proliferation, programmed cell death and transformation. Our recent work focuses on elucidating the signaling mechanism in inflammatory disease, such as severe sepsis and colitis-associated cancer, and neuronal degenerative disease like Alzheimer’s disease, using a multifaceted experimental approach involving biochemistry, molecular cell biology, proteomics, computational modeling and animal models. Our long-term goal is to identify potential therapeutic targets for prevention and treatment of inflammatory and infectious disease, cancer and neuronal degenerative disease.

    Collapse Biography 
    Collapse education and training
    University of Alabama at Birmingham (UAB)Ph.D.
    University of California, San DiegoPostdoctoral Fellow

    Collapse Research 
    Collapse research activities and funding
    R35GM122457     (LIN, ANNING)Jul 21, 2017 - Apr 30, 2022
    NIH
    IKK signaling network: TNF cytotoxicity, computational modeling and regulation
    Role: Principal Investigator
    R01GM103868     (LIN, ANNING)Jun 7, 2013 - Feb 28, 2019
    NIH
    Mechanism of IKK Signaling Network
    Role: Principal Investigator
    R01GM095313     (LIN, ANNING)Aug 1, 2011 - Jul 31, 2015
    NIH
    Regulation of TNFa signaling
    Role: Principal Investigator
    R01ES015868     (LIN, ANNING)Feb 8, 2008 - Jan 31, 2014
    NIH
    Wiring the UV Signaling Circuitry
    Role: Principal Investigator
    R01GM071409     (LIN, ANNING)May 1, 2006 - Apr 30, 2010
    NIH
    Targeting BAD by JNK for Cell Survival
    Role: Principal Investigator
    R13CA110473     (LIN, ANNING)Aug 19, 2004 - Aug 18, 2005
    NIH
    Support of Conference on Signal Transduction and Cancer
    Role: Principal Investigator
    R01CA100460     (LIN, ANNING)Jun 1, 2003 - Jun 30, 2011
    NIH
    Integration of TNF Signaling in Apoptosis
    Role: Principal Investigator
    R01CA092650     (LIN, ANNING)Sep 1, 2001 - Aug 31, 2006
    NIH
    Regulation of I kappa B Kinase in Apoptosis
    Role: Principal Investigator
    R29CA073740     (LIN, ANNING)Jun 1, 1997 - May 31, 2002
    NIH
    MOLECULAR MECHANISMS OF TNF ALPHA INDUCED CYTOTOXICITY
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Puckett MC, Goldman EH, Cockrell LM, Huang B, Kasinski AL, Du Y, Wang CY, Lin A, Ichijo H, Khuri F, Fu H. Correction for Puckett et al., "Integration of Apoptosis Signal-Regulating Kinase 1-Mediated Stress Signaling with the Akt/Protein Kinase B-I?B Kinase Cascade". Mol Cell Biol. 2022 Oct 20; 42(10):e0028222. PMID: 36036612; PMCID: PMC9583716.
      Citations:    Fields:    
    2. Zhang L, Li J, Lin A. Assessment of neurodegeneration and neuronal loss in aged 5XFAD mice. STAR Protoc. 2021 12 17; 2(4):100915. PMID: 34755118; PMCID: PMC8556527.
      Citations: 12     Fields:    Translation:Animals
    3. Zhang L, Qian Y, Li J, Zhou X, Xu H, Yan J, Xiang J, Yuan X, Sun B, Sisodia SS, Jiang YH, Cao X, Jing N, Lin A. BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology. iScience. 2021 Sep 24; 24(9):102942. PMID: 34430820; PMCID: PMC8369003.
      Citations: 29     
    4. Zhang W, Zhangyuan G, Wang F, Jin K, Shen H, Zhang L, Yuan X, Wang J, Zhang H, Yu W, Huang R, Xu X, Yin Y, Zhong G, Lin A, Sun B. The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation. Immunity. 2021 06 08; 54(6):1168-1185.e8. PMID: 34038747.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    5. Li J, Zhang L, Zheng Y, Shao R, Liang Q, Yu W, Wang H, Zou W, Wang D, Xiang J, Lin A. BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages. Elife. 2020 12 03; 9. PMID: 33270017; PMCID: PMC7714394.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    6. Li Y, Tang L, Yue J, Gou X, Lin A, Weatherbee SD, Wu X. Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKa. EMBO Rep. 2020 05 06; 21(5):e48566. PMID: 32239614; PMCID: PMC7202209.
      Citations: 13     Fields:    Translation:AnimalsCells
    7. Chen M, Yan R, Zhou K, Li X, Zhang Y, Liu C, Jiang M, Ye H, Meng X, Pang N, Zhao L, Liu J, Xiao W, Hu R, Cui Q, Zhong W, Zhao Y, Zhu M, Lin A, Ruan C, Dai K. Akt-mediated platelet apoptosis and its therapeutic implications in immune thrombocytopenia. Proc Natl Acad Sci U S A. 2018 11 06; 115(45):E10682-E10691. PMID: 30337485; PMCID: PMC6233141.
      Citations: 32     Fields:    Translation:HumansCells
    8. Yan J, Zhang H, Xiang J, Zhao Y, Yuan X, Sun B, Lin A. The BH3-only protein BAD mediates TNFa cytotoxicity despite concurrent activation of IKK and NF-?B in septic shock. Cell Res. 2018 07; 28(7):701-718. PMID: 29795446; PMCID: PMC6028455.
      Citations: 9     Fields:    Translation:AnimalsCells
    9. Zhao L, Liu J, He C, Yan R, Zhou K, Cui Q, Meng X, Li X, Zhang Y, Nie Y, Zhang Y, Hu R, Liu Y, Zhao L, Chen M, Xiao W, Tian J, Zhao Y, Cao L, Zhou L, Lin A, Ruan C, Dai K. Protein kinase A determines platelet life span and survival by regulating apoptosis. J Clin Invest. 2017 12 01; 127(12):4338-4351. PMID: 29083324; PMCID: PMC5707139.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    10. Budinger GRS, Kohanski RA, Gan W, Kobor MS, Amaral LA, Armanios M, Kelsey KT, Pardo A, Tuder R, Macian F, Chandel N, Vaughan D, Rojas M, Mora AL, Kovacs E, Duncan SR, Finkel T, Choi A, Eickelberg O, Chen D, Agusti A, Selman M, Balch WE, Busse P, Lin A, Morimoto R, Sznajder JI, Thannickal VJ. The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop. J Gerontol A Biol Sci Med Sci. 2017 Oct 12; 72(11):1492-1500. PMID: 28498894; PMCID: PMC5861849.
      Citations: 41     Fields:    Translation:Humans
    11. Lin AE, Autran CA, Szyszka A, Escajadillo T, Huang M, Godula K, Prudden AR, Boons GJ, Lewis AL, Doran KS, Nizet V, Bode L. Human milk oligosaccharides inhibit growth of group B Streptococcus. J Biol Chem. 2017 07 07; 292(27):11243-11249. PMID: 28416607; PMCID: PMC5500792.
      Citations: 88     Fields:    Translation:HumansCells
    12. Zhao Y, Lin Y, Zhang H, Mañas A, Tang W, Zhang Y, Wu D, Lin A, Xiang J. Ubl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branching. Proc Natl Acad Sci U S A. 2015 Aug 04; 112(31):9644-9. PMID: 26195787; PMCID: PMC4534221.
      Citations: 18     Fields:    Translation:AnimalsCells
    13. Yan J, Xiang J, Lin Y, Ma J, Zhang J, Zhang H, Sun J, Danial NN, Liu J, Lin A. Inactivation of BAD by IKK inhibits TNFa-induced apoptosis independently of NF-?B activation. Cell. 2013 Jan 17; 152(1-2):304-15. PMID: 23332762; PMCID: PMC3586589.
      Citations: 58     Fields:    Translation:AnimalsCells
    14. Liu J, Yan J, Jiang S, Wen J, Chen L, Zhao Y, Lin A. Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-a-induced JNK activation and inflammation. Proc Natl Acad Sci U S A. 2012 Jan 03; 109(1):191-6. PMID: 22184250; PMCID: PMC3252938.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    15. Lin A. ATIA: a link between inflammation and hypoxia. Mol Cell. 2011 Jun 10; 42(5):557-8. PMID: 21658597; PMCID: PMC3444288.
      Citations: 1     Fields:    
    16. Lin A. Temporal control of TNFa signaling by Miz1. Adv Exp Med Biol. 2011; 691:127-8. PMID: 21153316.
      Citations: 3     Fields:    Translation:Cells
    17. Sheng N, Xie Z, Wang C, Bai G, Zhang K, Zhu Q, Song J, Guillemot F, Chen YG, Lin A, Jing N. Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1. Proc Natl Acad Sci U S A. 2010 Nov 02; 107(44):18886-91. PMID: 20956305; PMCID: PMC2973900.
      Citations: 51     Fields:    Translation:AnimalsCells
    18. Lee DF, Kuo HP, Liu M, Chou CK, Xia W, Du Y, Shen J, Chen CT, Huo L, Hsu MC, Li CW, Ding Q, Liao TL, Lai CC, Lin AC, Chang YH, Tsai SF, Li LY, Hung MC. KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. Mol Cell. 2009 Oct 09; 36(1):131-40. PMID: 19818716; PMCID: PMC2770835.
      Citations: 210     Fields:    Translation:HumansAnimalsCells
    19. Liu J, Zhao Y, Eilers M, Lin A. Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation. Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43):18279-84. PMID: 19815509; PMCID: PMC2775337.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    20. Peng G, Han M, Du Y, Lin A, Yu L, Zhang Y, Jing N. SIP30 is regulated by ERK in peripheral nerve injury-induced neuropathic pain. J Biol Chem. 2009 Oct 30; 284(44):30138-47. PMID: 19723624; PMCID: PMC2781569.
      Citations: 19     Fields:    Translation:AnimalsCells
    21. Tang F, Kokontis J, Lin Y, Liao S, Lin A, Xiang J. Androgen via p21 inhibits tumor necrosis factor alpha-induced JNK activation and apoptosis. J Biol Chem. 2009 Nov 20; 284(47):32353-8. PMID: 19723627; PMCID: PMC2781650.
      Citations: 10     Fields:    Translation:HumansCells
    22. Deng H, Yu F, Chen J, Zhao Y, Xiang J, Lin A. Phosphorylation of Bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1. J Biol Chem. 2008 Jul 25; 283(30):20754-60. PMID: 18469002; PMCID: PMC2475697.
      Citations: 30     Fields:    Translation:AnimalsCells
    23. Shen C, Chen Y, Liu H, Zhang K, Zhang T, Lin A, Jing N. Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase. J Biol Chem. 2008 Jun 20; 283(25):17721-30. PMID: 18436531; PMCID: PMC2427353.
      Citations: 81     Fields:    Translation:HumansAnimals
    24. Graham WV, Wang F, Clayburgh DR, Cheng JX, Yoon B, Wang Y, Lin A, Turner JR. Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter. J Biol Chem. 2006 Sep 08; 281(36):26205-15. PMID: 16835238.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    25. Lin Y, Kokontis J, Tang F, Godfrey B, Liao S, Lin A, Chen Y, Xiang J. Androgen and its receptor promote Bax-mediated apoptosis. Mol Cell Biol. 2006 Mar; 26(5):1908-16. PMID: 16479009; PMCID: PMC1430231.
      Citations: 34     Fields:    Translation:HumansCells
    26. Lin A. A five-year itch in TNF-alpha cytotoxicity: the time factor determines JNK action. Dev Cell. 2006 Mar; 10(3):277-8. PMID: 16516830.
      Citations: 6     Fields:    Translation:AnimalsCells
    27. Liu J, Yang D, Minemoto Y, Leitges M, Rosner MR, Lin A. NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. Mol Cell. 2006 Feb 17; 21(4):467-80. PMID: 16483929.
      Citations: 48     Fields:    Translation:AnimalsCells
    28. Zhang J, Bui TN, Xiang J, Lin A. Cyclic AMP inhibits p38 activation via CREB-induced dynein light chain. Mol Cell Biol. 2006 Feb; 26(4):1223-34. PMID: 16449637; PMCID: PMC1367190.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    29. Zhang J, Liu J, Yu C, Lin A. BAD Ser128 is not phosphorylated by c-Jun NH2-terminal kinase for promoting apoptosis. Cancer Res. 2005 Sep 15; 65(18):8372-8. PMID: 16166315.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    30. Liu J, Lin A. Role of JNK activation in apoptosis: a double-edged sword. Cell Res. 2005 Jan; 15(1):36-42. PMID: 15686625.
      Citations: 321     Fields:    Translation:HumansAnimalsCells
    31. Liu J, Minemoto Y, Lin A. c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis. Mol Cell Biol. 2004 Dec; 24(24):10844-56. PMID: 15572687; PMCID: PMC533995.
      Citations: 96     Fields:    Translation:AnimalsCells
    32. Yu C, Minemoto Y, Zhang J, Liu J, Tang F, Bui TN, Xiang J, Lin A. JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell. 2004 Feb 13; 13(3):329-40. PMID: 14967141.
      Citations: 112     Fields:    Translation:AnimalsCells
    33. Liu H, Ma Y, Pagliari LJ, Perlman H, Yu C, Lin A, Pope RM. TNF-alpha-induced apoptosis of macrophages following inhibition of NF-kappa B: a central role for disruption of mitochondria. J Immunol. 2004 Feb 01; 172(3):1907-15. PMID: 14734776.
      Citations: 41     Fields:    Translation:HumansCells
    34. Lin A, Karin M. NF-kappaB in cancer: a marked target. Semin Cancer Biol. 2003 Apr; 13(2):107-14. PMID: 12654254.
      Citations: 113     Fields:    Translation:HumansAnimalsCells
    35. Lin A. Activation of the JNK signaling pathway: breaking the brake on apoptosis. Bioessays. 2003 Jan; 25(1):17-24. PMID: 12508278.
      Citations: 126     Fields:    Translation:HumansAnimalsCells
    36. Lin A, Dibling B. The true face of JNK activation in apoptosis. Aging Cell. 2002 Dec; 1(2):112-6. PMID: 12882340.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    37. Tang F, Tang G, Xiang J, Dai Q, Rosner MR, Lin A. The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol. 2002 Dec; 22(24):8571-9. PMID: 12446776; PMCID: PMC139858.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    38. Li J, Johnson XD, Iazvovskaia S, Tan A, Lin A, Hershenson MB. Signaling intermediates required for NF-kappa B activation and IL-8 expression in CF bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2003 Feb; 284(2):L307-15. PMID: 12388360.
      Citations: 22     Fields:    Translation:HumansCells
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