 Growth Differentiation Factor 2
"Growth Differentiation Factor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A growth differentiation factor that plays a regulatory role as a paracrine factor for a diverse array of cell types during EMBRYONIC DEVELOPMENT and in the adult tissues. Growth differentiation factor 2 is also a potent regulator of CHONDROGENESIS and was previously referred to as bone morphogenetic protein 9.
| Descriptor ID |
D055427
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| MeSH Number(s) |
D12.644.276.954.200.910 D12.644.276.954.300.200 D12.776.467.942.200.910 D12.776.467.942.300.200 D23.529.942.200.910 D23.529.942.300.200
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Growth Differentiation Factor 2".
Below are MeSH descriptors whose meaning is more specific than "Growth Differentiation Factor 2".
This graph shows the total number of publications written about "Growth Differentiation Factor 2" by people in this website by year, and whether "Growth Differentiation Factor 2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2004 | 0 | 3 | 3 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2010 | 3 | 0 | 3 | | 2011 | 1 | 1 | 2 | | 2012 | 2 | 1 | 3 | | 2013 | 3 | 1 | 4 | | 2014 | 2 | 4 | 6 | | 2015 | 2 | 0 | 2 | | 2016 | 1 | 2 | 3 | | 2017 | 3 | 4 | 7 | | 2018 | 1 | 3 | 4 | | 2019 | 3 | 2 | 5 | | 2020 | 4 | 0 | 4 | | 2021 | 1 | 1 | 2 | | 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Growth Differentiation Factor 2" by people in Profiles.
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Luo W, Liang P, Zhao T, Cheng Q, Liu H, He L, Zhang L, Huang B, Zhang Y, He T, Yang D. Reversely immortalized mouse salivary gland cells presented a promising metabolic and fibrotic response upon BMP9/Gdf2 stimulation. Cell Mol Biol Lett. 2022 Jun 11; 27(1):46.
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Luo W, Zhang L, Huang B, Zhang H, Zhang Y, Zhang F, Liang P, Chen Q, Cheng Q, Tan D, Tan Y, Song J, Zhao T, Haydon RC, Reid RR, Luu HH, Lee MJ, El Dafrawy M, Ji P, He TC, Gou L. BMP9-initiated osteogenic/odontogenic differentiation of mouse tooth germ mesenchymal cells (TGMCS) requires Wnt/ß-catenin signalling activity. J Cell Mol Med. 2021 03; 25(5):2666-2678.
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Li R, Zhang W, Yan Z, Liu W, Fan J, Feng Y, Zeng Z, Cao D, Haydon RC, Luu HH, Deng ZL, He TC, Zou Y. Long non-coding RNA (LncRNA) HOTAIR regulates BMP9-induced osteogenic differentiation by targeting the proliferation of mesenchymal stem cells (MSCs). Aging (Albany NY). 2021 01 10; 13(3):4199-4214.
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Theilmann AL, Hawke LG, Hilton LR, Whitford MKM, Cole DV, Mackeil JL, Dunham-Snary KJ, Mewburn J, James PD, Maurice DH, Archer SL, Ormiston ML. Endothelial BMPR2 Loss Drives a Proliferative Response to BMP (Bone Morphogenetic Protein) 9 via Prolonged Canonical Signaling. Arterioscler Thromb Vasc Biol. 2020 11; 40(11):2605-2618.
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Zhang B, Yang L, Zeng Z, Feng Y, Wang X, Wu X, Luo H, Zhang J, Zhang M, Pakvasa M, Wagstaff W, He F, Mao Y, Qin K, Ding H, Zhang Y, Niu C, Wu M, Zhao X, Wang H, Huang L, Shi D, Liu Q, Ni N, Fu K, Athiviraham A, Moriatis Wolf J, Lee MJ, Hynes K, Strelzow J, El Dafrawy M, Xia Y, He TC. Leptin Potentiates BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells Through the Activation of JAK/STAT Signaling. Stem Cells Dev. 2020 04 15; 29(8):498-510.
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Hodgson J, Swietlik EM, Salmon RM, Hadinnapola C, Nikolic I, Wharton J, Guo J, Liley J, Haimel M, Bleda M, Southgate L, Machado RD, Martin JM, Treacy CM, Yates K, Daugherty LC, Shamardina O, Whitehorn D, Holden S, Bogaard HJ, Church C, Coghlan G, Condliffe R, Corris PA, Danesino C, Eyries M, Gall H, Ghio S, Ghofrani HA, Gibbs JSR, Girerd B, Houweling AC, Howard L, Humbert M, Kiely DG, Kovacs G, Lawrie A, MacKenzie Ross RV, Moledina S, Montani D, Olschewski A, Olschewski H, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Prokopenko I, Rhodes CJ, Scelsi L, Seeger W, Soubrier F, Suntharalingam J, Toshner MR, Trembath RC, Vonk Noordegraaf A, Wort SJ, Wilkins MR, Yu PB, Li W, Gräf S, Upton PD, Morrell NW. Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2020 03 01; 201(5):575-585.
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Song D, Huang S, Zhang L, Liu W, Huang B, Feng Y, Liu B, He TC, Huang D, Reid RR. Differential Responsiveness to BMP9 between Patent and Fused Suture Progenitor Cells from Craniosynostosis Patients. Plast Reconstr Surg. 2020 03; 145(3):552e-562e.
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Zhang Z, Liu J, Zeng Z, Fan J, Huang S, Zhang L, Zhang B, Wang X, Feng Y, Ye Z, Zhao L, Cao D, Yang L, Pakvasa M, Liu B, Wagstaff W, Wu X, Luo H, Zhang J, Zhang M, He F, Mao Y, Ding H, Zhang Y, Niu C, Haydon RC, Luu HH, Lee MJ, Wolf JM, Shao Z, He TC. lncRNA Rmst acts as an important mediator of BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs) by antagonizing Notch-targeting microRNAs. Aging (Albany NY). 2019 12 11; 11(24):12476-12496.
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Alverdy AK, Pakvasa M, Zhao C, Mostafa S, Liu W, Luo W, Wolf JM, Ameer GA, He TC, Reid RR. Imiquimod Acts Synergistically with BMP9 through the Notch Pathway as an Osteoinductive Agent In Vitro. Plast Reconstr Surg. 2019 11; 144(5):1094-1103.
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Wang X, Yuan C, Huang B, Fan J, Feng Y, Li AJ, Zhang B, Lei Y, Ye Z, Zhao L, Cao D, Yang L, Wu D, Chen X, Liu B, Wagstaff W, He F, Wu X, Luo H, Zhang J, Zhang M, Haydon RC, Luu HH, Lee MJ, Moriatis Wolf J, Huang A, He TC, Zeng Z. Developing a Versatile Shotgun Cloning Strategy for Single-Vector-Based Multiplex Expression of Short Interfering RNAs (siRNAs) in Mammalian Cells. ACS Synth Biol. 2019 09 20; 8(9):2092-2105.
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