 Alzheimer Disease
"Alzheimer Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Descriptor ID |
D000544
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| MeSH Number(s) |
C10.228.140.380.100 C10.574.945.249 F03.087.400.100
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| Concept/Terms |
Alzheimer Disease- Alzheimer Disease
- Disease, Alzheimer
- Alzheimer's Disease
- Disease, Alzheimer's
- Primary Senile Degenerative Dementia
- Dementia, Alzheimer Type
- Alzheimer Type Dementia
- Senile Dementia, Alzheimer Type
- Alzheimer Type Senile Dementia
- Dementia, Primary Senile Degenerative
- Dementia, Senile
- Dementias, Senile
- Senile Dementia
- Senile Dementias
Dementia, Presenile- Dementia, Presenile
- Dementias, Presenile
- Presenile Dementia
- Presenile Dementias
Alzheimer Disease, Early Onset- Alzheimer Disease, Early Onset
- Early Onset Alzheimer Disease
- Presenile Alzheimer Dementia
- Alzheimer Dementia, Presenile
- Dementia, Presenile Alzheimer
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Below are MeSH descriptors whose meaning is more general than "Alzheimer Disease".
Below are MeSH descriptors whose meaning is more specific than "Alzheimer Disease".
This graph shows the total number of publications written about "Alzheimer Disease" by people in this website by year, and whether "Alzheimer Disease" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 1 | 0 | 1 | | 1985 | 1 | 1 | 2 | | 1988 | 3 | 0 | 3 | | 1989 | 1 | 0 | 1 | | 1990 | 5 | 0 | 5 | | 1991 | 10 | 0 | 10 | | 1992 | 6 | 1 | 7 | | 1993 | 6 | 3 | 9 | | 1994 | 8 | 3 | 11 | | 1995 | 4 | 3 | 7 | | 1996 | 13 | 1 | 14 | | 1997 | 10 | 3 | 13 | | 1998 | 8 | 8 | 16 | | 1999 | 10 | 3 | 13 | | 2000 | 6 | 5 | 11 | | 2001 | 4 | 4 | 8 | | 2002 | 8 | 3 | 11 | | 2003 | 7 | 4 | 11 | | 2004 | 11 | 1 | 12 | | 2005 | 10 | 5 | 15 | | 2006 | 8 | 3 | 11 | | 2007 | 5 | 2 | 7 | | 2008 | 2 | 6 | 8 | | 2009 | 2 | 1 | 3 | | 2010 | 6 | 5 | 11 | | 2011 | 4 | 5 | 9 | | 2012 | 2 | 1 | 3 | | 2013 | 11 | 1 | 12 | | 2014 | 1 | 1 | 2 | | 2015 | 0 | 2 | 2 | | 2016 | 3 | 2 | 5 | | 2017 | 9 | 1 | 10 | | 2018 | 7 | 1 | 8 | | 2019 | 7 | 1 | 8 | | 2020 | 5 | 0 | 5 | | 2021 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Alzheimer Disease" by people in Profiles.
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Zhang X, Zhang CM, Prokopenko D, Liang Y, Zhen SY, Weigle IQ, Han W, Aryal M, Tanzi RE, Sisodia SS. An APP ectodomain mutation outside of the Aß domain promotes Aß production in vitro and deposition in vivo. J Exp Med. 2021 06 07; 218(6).
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Dumitrescu L, Mahoney ER, Mukherjee S, Lee ML, Bush WS, Engelman CD, Lu Q, Fardo DW, Trittschuh EH, Mez J, Kaczorowski C, Hernandez Saucedo H, Widaman KF, Buckley R, Properzi M, Mormino E, Yang HS, Harrison T, Hedden T, Nho K, Andrews SJ, Tommet D, Hadad N, Sanders RE, Ruderfer DM, Gifford KA, Moore AM, Cambronero F, Zhong X, Raghavan NS, Vardarajan B. Genetic variants and functional pathways associated with resilience to Alzheimer's disease. Brain. 2020 08 01; 143(8):2561-2575.
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Cable J, Holtzman DM, Hyman BT, Tansey MG, Colonna M, Kellis M, Brinton RD, Albert M, Wellington CL, Sisodia SS, Tanzi RE. Alternatives to amyloid for Alzheimer's disease therapies-a symposium report. Ann N Y Acad Sci. 2020 09; 1475(1):3-14.
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Dodiya HB, Frith M, Sidebottom A, Cao Y, Koval J, Chang E, Sisodia SS. Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer's transgenic mice. Sci Rep. 2020 05 18; 10(1):8183.
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Zhang X, Zhang C, Prokopenko D, Liang Y, Han W, Tanzi RE, Sisodia SS. Negative evidence for a role of APH1B T27I variant in Alzheimer's disease. Hum Mol Genet. 2020 04 15; 29(6):955-966.
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Despa F, Goldstein LB, Biessels GJ. Amylin as a Potential Link between Type 2 Diabetes and Alzheimer Disease. Ann Neurol. 2020 03; 87(3):486.
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Avery EW, Yoo K, Rosenberg MD, Greene AS, Gao S, Na DL, Scheinost D, Constable TR, Chun MM. Distributed Patterns of Functional Connectivity Predict Working Memory Performance in Novel Healthy and Memory-impaired Individuals. J Cogn Neurosci. 2020 02; 32(2):241-255.
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Yu L, Wei F, Liang J, Ren G, Liu X, Wang CZ, Yuan J, Zeng J, Luo Y, Bi Y, Yuan CS. Target Molecular-Based Neuroactivity Screening and Analysis of Panax ginseng by Affinity Ultrafiltration, UPLC-QTOF-MS and Molecular Docking. Am J Chin Med. 2019; 47(6):1345-1363.
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Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Bush WS, Gifford KA, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Deming Y, Chao MJ, Huentelman M, Martin ER, Hamilton-Nelson K, Shaw LM, Trojanowski JQ, Peskind ER, Cruchaga C, Pericak-Vance MA, Goate AM, Cox NJ, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M. Sex differences in the genetic predictors of Alzheimer's pathology. Brain. 2019 09 01; 142(9):2581-2589.
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Fu CH, Iascone DM, Petrof I, Hazra A, Zhang X, Pyfer MS, Tosi U, Corbett BF, Cai J, Lee J, Park J, Iacovitti L, Scharfman HE, Enikolopov G, Chin J. Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer's Disease Model. Cell Rep. 2019 06 25; 27(13):3741-3751.e4.
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