 Aromatase
"Aromatase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
| Descriptor ID |
D001141
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| MeSH Number(s) |
D08.244.453.915.099 D08.811.682.690.708.170.915.099 D08.811.682.690.708.783.099 D12.776.422.220.453.915.099
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| Concept/Terms |
Aromatase- Aromatase
- CYP 19
- CYP19
- CYP19 Protein
- Protein, CYP19
- P450AROM
- Cytochrome P-450(AROM)
- Cytochrome P450 19
- Estrogen Synthase
- Estrogen Synthetase
- Androstenedione Aromatase
- Aromatase, Androstenedione
- Cytochrome P-450 CYP19
- Cytochrome P 450 CYP19
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Below are MeSH descriptors whose meaning is more general than "Aromatase".
Below are MeSH descriptors whose meaning is more specific than "Aromatase".
This graph shows the total number of publications written about "Aromatase" by people in this website by year, and whether "Aromatase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1982 | 1 | 0 | 1 | | 1988 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 1 | 2 | | 2013 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Aromatase" by people in Profiles.
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Hobeika E, Armouti M, Kala H, Fierro MA, Winston NJ, Scoccia B, Zamah AM, Stocco C. Oocyte-Secreted Factors Synergize With FSH to Promote Aromatase Expression in Primary Human Cumulus Cells. J Clin Endocrinol Metab. 2019 05 01; 104(5):1667-1676.
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Baumgarten SC, Convissar SM, Zamah AM, Fierro MA, Winston NJ, Scoccia B, Stocco C. FSH Regulates IGF-2 Expression in Human Granulosa Cells in an AKT-Dependent Manner. J Clin Endocrinol Metab. 2015 Aug; 100(8):E1046-55.
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Liu M, Ingle JN, Fridley BL, Buzdar AU, Robson ME, Kubo M, Wang L, Batzler A, Jenkins GD, Pietrzak TL, Carlson EE, Goetz MP, Northfelt DW, Perez EA, Williard CV, Schaid DJ, Nakamura Y, Weinshilboum RM. TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression. Mol Endocrinol. 2013 Apr; 27(4):657-70.
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Chung SJ, Armasu SM, Biernacka JM, Lesnick TG, Rider DN, Cunningham JM, Maraganore DM. Variants in estrogen-related genes and risk of Parkinson's disease. Mov Disord. 2011 Jun; 26(7):1234-42.
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Talbott KE, Gammon MD, Kibriya MG, Chen Y, Teitelbaum SL, Long CM, Gurvich I, Santella RM, Ahsan H. A CYP19 (aromatase) polymorphism is associated with increased premenopausal breast cancer risk. Breast Cancer Res Treat. 2008 Oct; 111(3):481-7.
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Zouboulis CC, Chen WC, Thornton MJ, Qin K, Rosenfield R. Sexual hormones in human skin. Horm Metab Res. 2007 Feb; 39(2):85-95.
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Schlinger BA, London SE. Neurosteroids and the songbird model system. J Exp Zool A Comp Exp Biol. 2006 Sep 01; 305(9):743-8.
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Whittemore AS, Halpern J, Ahsan H. Covariate adjustment in family-based association studies. Genet Epidemiol. 2005 Apr; 28(3):244-55.
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Ahsan H, Whittemore AS, Chen Y, Senie RT, Hamilton SP, Wang Q, Gurvich I, Santella RM. Variants in estrogen-biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family-based genetic association study. Breast Cancer Res. 2005; 7(1):R71-81.
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West NB, Roselli CE, Resko JA, Greene GL, Brenner RM. Estrogen and progestin receptors and aromatase activity in rhesus monkey prostate. Endocrinology. 1988 Nov; 123(5):2312-22.
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