25-Hydroxyvitamin D3 1-alpha-Hydroxylase
"25-Hydroxyvitamin D3 1-alpha-Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
| Descriptor ID |
D015090
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| MeSH Number(s) |
D08.244.453.499.500 D08.244.453.915.400 D08.811.682.690.708.170.493.500 D08.811.682.690.708.170.915.400 D12.776.422.220.453.499.500 D12.776.422.220.453.915.400
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| Concept/Terms |
25-Hydroxyvitamin D3 1-alpha-Hydroxylase- 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
- 25 Hydroxyvitamin D3 1 alpha Hydroxylase
- 25-Hydroxycholecalciferol 1-Hydroxylase
- Calcidiol 1-Monooxygenase
- Calcidiol 1 Monooxygenase
- 25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase
- 25-Hydroxyvitamin D 1-alpha-Hydroxylase
- 1-alpha-Hydroxylase, 25-Hydroxyvitamin D
- 25 Hydroxyvitamin D 1 alpha Hydroxylase
- CYP27B1
- Cytochrome P-450 CYP27B1
- Cytochrome P 450 CYP27B1
- 25-Hydroxyergocalciferol 1-alpha-Hydroxylase
- 1-alpha-Hydroxylase, 25-Hydroxyergocalciferol
- 25 Hydroxyergocalciferol 1 alpha Hydroxylase
- 25-Hydroxycholecalciferol-1-Hydroxylase
- 25 Hydroxycholecalciferol 1 Hydroxylase
- 25-Hydroxyvitamin D2 1-hydroxylase
- 1-hydroxylase, 25-Hydroxyvitamin D2
- 25 Hydroxyvitamin D2 1 hydroxylase
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Below are MeSH descriptors whose meaning is more general than "25-Hydroxyvitamin D3 1-alpha-Hydroxylase".
Below are MeSH descriptors whose meaning is more specific than "25-Hydroxyvitamin D3 1-alpha-Hydroxylase".
This graph shows the total number of publications written about "25-Hydroxyvitamin D3 1-alpha-Hydroxylase" by people in this website by year, and whether "25-Hydroxyvitamin D3 1-alpha-Hydroxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2006 | 0 | 2 | 2 |
| 2008 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "25-Hydroxyvitamin D3 1-alpha-Hydroxylase" by people in Profiles.
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Ex vivo culture of primary human colonic tissue for studying transcriptional responses to 1a,25(OH)2 and 25(OH) vitamin D. Physiol Genomics. 2014 Apr 15; 46(8):302-8.
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Ethanol extract of Fructus Ligustri Lucidi increases circulating 1,25-dihydroxyvitamin D3 by inducing renal 25-hydroxyvitamin D-1a hydroxylase activity. Menopause. 2010 Nov-Dec; 17(6):1174-81.
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1alpha,25-Dihydroxyvitamin D hydroxylase in adipocytes. J Steroid Biochem Mol Biol. 2008 Nov; 112(1-3):122-6.
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Ovariectomy worsens secondary hyperparathyroidism in mature rats during low-Ca diet. Am J Physiol Endocrinol Metab. 2007 Mar; 292(3):E723-31.
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Altered vitamin D metabolism in type II diabetic mouse glomeruli may provide protection from diabetic nephropathy. Kidney Int. 2006 Sep; 70(5):882-91.
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Adaptive responses of 25-hydroxyvitamin D3 1-alpha hydroxylase expression to dietary phosphate restriction in young and adult rats. Biochim Biophys Acta. 2003 Sep 01; 1639(1):34-42.
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Insulin-like growth factor I increases renal 1,25(OH)2D3 biosynthesis during low-P diet in adult rats. Am J Physiol. 1997 Jun; 272(6 Pt 2):F698-703.
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Effect of hypercalcemia-producing tumor on 1,25(OH)2D3 biosynthesis in athymic mice. Am J Physiol. 1989 Feb; 256(2 Pt 1):E309-14.
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Evidence for calcium-dependent control of 1,25-dihydroxyvitamin D3 production by rat kidney proximal tubules. J Biol Chem. 1986 Aug 25; 261(24):11224-9.