"Baclofen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.
| Descriptor ID |
D001418
|
| MeSH Number(s) |
D02.241.081.114.500.350.100
|
| Concept/Terms |
Baclofen- Baclofen
- Baclophen
- PCP-GABA
- beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid
- Chlorophenyl GABA
- GABA, Chlorophenyl
- beta-(p-Chlorophenyl)-gamma-aminobutyric Acid
Ba-34,647- Ba-34,647
- Ba34,647
- Ba-34647
- Ba34647
- CIBA-34,647-BA
- CIBA34,647BA
|
Below are MeSH descriptors whose meaning is more general than "Baclofen".
Below are MeSH descriptors whose meaning is more specific than "Baclofen".
This graph shows the total number of publications written about "Baclofen" by people in this website by year, and whether "Baclofen" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 2 | 3 |
| 2004 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2010 | 1 | 1 | 2 |
| 2012 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Baclofen" by people in Profiles.
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Arbaclofen in Children and Adolescents with Autism Spectrum Disorder: A Randomized, Controlled, Phase 2 Trial. Neuropsychopharmacology. 2017 Jun; 42(7):1390-1398.
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Impact of antibiotic prophylaxis for intrathecal baclofen pump surgery in pediatric patients. Neurosurg Focus. 2015 Dec; 39(6):E10.
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STX209 (arbaclofen) for autism spectrum disorders: an 8-week open-label study. J Autism Dev Disord. 2014 Apr; 44(4):958-64.
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Effects of STX209 (arbaclofen) on neurobehavioral function in children and adults with fragile X syndrome: a randomized, controlled, phase 2 trial. Sci Transl Med. 2012 Sep 19; 4(152):152ra127.
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Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors. Nat Neurosci. 2011 Jul 10; 14(8):1033-8.
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Growth hormone responses to GABAB receptor challenge with baclofen and impulsivity in healthy control and personality disorder subjects. Psychopharmacology (Berl). 2011 May; 215(1):41-8.
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Type B GABA receptors contribute to the restoration of balance during vestibular compensation in mice. Neuroscience. 2010 Aug 11; 169(1):302-14.
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Behavioral characteristics and neural mechanisms mediating performance in a rodent version of the Balloon Analog Risk Task. Neuropsychopharmacology. 2010 Jul; 35(8):1797-806.
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Head-shaking nystagmus and new technology. Neurology. 2007 Apr 24; 68(17):1333-4.
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Persistent hiccups after attempted interscalene brachial plexus block. Reg Anesth Pain Med. 2005 Nov-Dec; 30(6):574-6.