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Chun-Su Yuan

TitleProfessor
InstitutionUniversity of Chicago
DepartmentAnesthesia and Critical Care
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Current Fields of Research: Mechanisms of opioid pharmacological actions; Antagonism of opioid side effects, especially opioid bowel dysfunction; New drug development / Preclinical and Phase I, II, III clinical trials; Complementary and integrative medicine; Benefits and risks of herbal medicines.

    Collapse Biography 
    Collapse education and training
    Shanghai Second Medical College, Shanghai, ChinaM.D.1975Medicine
    Educational Commission for Foreign Medical Graduates (ECFMG), U.S.A.M.D. equivalency 1983Medicine
    University of Arizona, Tucson, AZPh.D.1986Physiology
    University of Chicago, Chicago, ILFellowship1996Clinical Pharmacology

    Collapse Research 
    Collapse research activities and funding
    P01AT004418     (YUAN, CHUN-SU)Sep 30, 2008 - Jan 31, 2015
    NIH
    Center for Herbal Research on Colorectal Cancer
    Role: Principal Investigator
    R21AT003255     (YUAN, CHUN-SU)May 1, 2007 - Apr 30, 2010
    NIH
    Herbal Effects on Oxidant Dynamics in Cardiomyocytes
    Role: Principal Investigator
    R21AT002445     (YUAN, CHUN-SU)Apr 1, 2005 - Mar 31, 2008
    NIH
    EFFECT OF GINSENG ON CISPLATIN-INDUCED EMESIS
    Role: Principal Investigator
    R21AT002176     (YUAN, CHUN-SU)Apr 1, 2004 - Mar 31, 2007
    NIH
    CARDIOPROTECTIVE EFFECTS OF AMERICAN GINSENG
    Role: Principal Investigator
    R21AT000563     (YUAN, CHUN-SU)Mar 15, 2002 - Jan 31, 2005
    NIH
    R21 Project: Anti-diabetic Effects of Panax ginseng
    Role: Principal Investigator
    R21AT000381     (YUAN, CHUN-SU)Sep 20, 2001 - Aug 31, 2003
    NIH
    Cardiovascular Effects of Scutellaria baicelensis
    Role: Principal Investigator
    R01CA079042     (YUAN, CHUN-SU)Feb 18, 2000 - Jan 31, 2005
    NIH
    IMPROVING OF CARE BY REVERSAL OF OPIOID CONSTIPATION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wang CZ, Huang WH, Zhang CF, Wan JY, Wang Y, Yu C, Williams S, He TC, Du W, Musch MW, Chang EB, Yuan CS. Correction to: Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice. Clin Transl Oncol. 2018 03; 20(3):425. PMID: 29027650.
      Citations: 1     Fields:    
    2. Wang CZ, Huang WH, Zhang CF, Wan JY, Wang Y, Yu C, Williams S, He TC, Du W, Musch MW, Chang EB, Yuan CS. Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice [corrected]. Clin Transl Oncol. 2018 03; 20(3):302-312. PMID: 28808878; PMCID: PMC5812846.
      Citations: 18     Fields:    Translation:Animals
    3. Yuan J, Chen Y, Liang J, Wang CZ, Liu X, Yan Z, Tang Y, Li J, Yuan CS. Component analysis and target cell-based neuroactivity screening of Panax ginseng by ultra-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Dec 01; 1038:1-11. PMID: 27776327; PMCID: PMC5130230.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    4. Hasebe T, Matsukawa J, Ringus D, Miyoshi J, Hart J, Kaneko A, Yamamoto M, Kono T, Fujiya M, Kohgo Y, Wang CZ, Yuan CS, Bissonnette M, Musch MW, Chang EB. Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APCmin/+ Mouse Models of Experimental Colon Cancer. Phytother Res. 2017 Jan; 31(1):90-99. PMID: 27730672; PMCID: PMC5590753.
      Citations: 3     Fields:    Translation:Animals
    5. Wang CZ, Yu C, Wen XD, Chen L, Zhang CF, Calway T, Qiu Y, Wang Y, Zhang Z, Anderson S, Wang Y, Jia W, Yuan CS. American Ginseng Attenuates Colitis-Associated Colon Carcinogenesis in Mice: Impact on Gut Microbiota and Metabolomics. Cancer Prev Res (Phila). 2016 Oct; 9(10):803-811. PMID: 27443884; PMCID: PMC5052115.
      Citations: 31     Fields:    Translation:Animals
    6. Wan JY, Wang CZ, Liu Z, Zhang QH, Musch MW, Bissonnette M, Chang EB, Li P, Qi LW, Yuan CS. Determination of American ginseng saponins and their metabolites in human plasma, urine and feces samples by liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 15; 1015-1016:62-73. PMID: 26896573; PMCID: PMC4789086.
      Citations: 15     Fields:    Translation:HumansAnimals
    7. Wang CZ, Anderson S, Yuan CS. Phytochemistry and Anticancer Potential of Notoginseng. Am J Chin Med. 2016; 44(1):23-34. PMID: 26916912.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    8. Wang CZ, Anderson S, DU W, He TC, Yuan CS. Red ginseng and cancer treatment. Chin J Nat Med. 2016 Jan; 14(1):7-16. PMID: 26850342.
      Citations: 68     Fields:    Translation:HumansAnimals
    9. Wang CZ, Zhang CF, Chen L, Anderson S, Lu F, Yuan CS. Colon cancer chemopreventive effects of baicalein, an active enteric microbiome metabolite from baicalin. Int J Oncol. 2015 Nov; 47(5):1749-58. PMID: 26398706; PMCID: PMC4599184.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    10. Wang CZ, Cai Y, Anderson S, Yuan CS. Ginseng Metabolites on Cancer Chemoprevention: An Angiogenesis Link? Diseases. 2015 Sep; 3(3):193-204. PMID: 26941993; PMCID: PMC4773028.
      Citations: 18     
    11. Wang CZ, Moss J, Yuan CS. Commonly Used Dietary Supplements on Coagulation Function during Surgery. Medicines (Basel). 2015 Sep; 2(3):157-185. PMID: 26949700; PMCID: PMC4777343.
      Citations: 17     
    12. Wang CZ, Zhang Z, Wan JY, Zhang CF, Anderson S, He X, Yu C, He TC, Qi LW, Yuan CS. Protopanaxadiol, an active ginseng metabolite, significantly enhances the effects of fluorouracil on colon cancer. Nutrients. 2015 Jan 23; 7(2):799-814. PMID: 25625815; PMCID: PMC4344561.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    13. Wu XH, Wang CZ, Wang SQ, Mi C, He Y, Zhang J, Zhang YW, Anderson S, Yuan CS. Anti-hyperuricemia effects of allopurinol are improved by Smilax riparia, a traditional Chinese herbal medicine. J Ethnopharmacol. 2015 Mar 13; 162:362-8. PMID: 25617746.
      Citations: 17     Fields:    Translation:AnimalsCells
    14. Yu C, Wen XD, Zhang Z, Zhang CF, Wu X, He X, Liao Y, Wu N, Wang CZ, Du W, He TC, Yuan CS. American ginseng significantly reduced the progression of high-fat-diet-enhanced colon carcinogenesis in Apc (Min/+) mice. J Ginseng Res. 2015 Jul; 39(3):230-7. PMID: 26199554; PMCID: PMC4506368.
      Citations: 9     
    15. Zhang Z, Li Z, Wu X, Zhang CF, Calway T, He TC, Du W, Chen J, Wang CZ, Yuan CS. TRAIL pathway is associated with inhibition of colon cancer by protopanaxadiol. J Pharmacol Sci. 2015 Jan; 127(1):83-91. PMID: 25704023; PMCID: PMC5053100.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    16. Wu XH, Wang CZ, Zhang J, Wang SQ, Han L, Zhang YW, Yuan CS. Effects of Smilaxchinoside A and Smilaxchinoside C, two steroidal glycosides from Smilax riparia, on hyperuricemia in a mouse model. Phytother Res. 2014 Dec; 28(12):1822-8. PMID: 25098402.
      Citations: 5     Fields:    Translation:Animals
    17. Zhang Z, Yu C, Zhang CF, Wu XH, Wen XD, Anderson S, Du W, Huang WH, Li SP, Wang CZ, Yuan CS. Chemopreventive effects of oplopantriol A, a novel compound isolated from Oplopanax horridus, on colorectal cancer. Nutrients. 2014 Jul 18; 6(7):2668-80. PMID: 25045937; PMCID: PMC4113763.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    18. Yu C, Wen XD, Zhang Z, Zhang CF, Wu XH, Martin A, Du W, He TC, Wang CZ, Yuan CS. American ginseng attenuates azoxymethane/dextran sodium sulfate-induced colon carcinogenesis in mice. J Ginseng Res. 2015 Jan; 39(1):14-21. PMID: 25535472; PMCID: PMC4268560.
      Citations: 20     
    19. Yu C, Wang CZ, Zhou CJ, Wang B, Han L, Zhang CF, Wu XH, Yuan CS. Adulteration and cultivation region identification of American ginseng using HPLC coupled with multivariate analysis. J Pharm Biomed Anal. 2014 Oct; 99:8-15. PMID: 25044150; PMCID: PMC4151300.
      Citations: 23     Fields:    Translation:AnimalsPHPublic Health
    20. Ueno N, Hasebe T, Kaneko A, Yamamoto M, Fujiya M, Kohgo Y, Kono T, Wang CZ, Yuan CS, Bissonnette M, Chang EB, Musch MW. TU-100 (Daikenchuto) and ginger ameliorate anti-CD3 antibody induced T cell-mediated murine enteritis: microbe-independent effects involving Akt and NF-?B suppression. PLoS One. 2014; 9(5):e97456. PMID: 24857966; PMCID: PMC4032249.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    21. Jin HR, Liao Y, Li X, Zhang Z, Zhao J, Wang CZ, Huang WH, Li SP, Yuan CS, Du W. Anticancer compound Oplopantriol A kills cancer cells through inducing ER stress and BH3 proteins Bim and Noxa. Cell Death Dis. 2014 Apr 24; 5:e1190. PMID: 24763047; PMCID: PMC4001317.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    22. Zhang CF, Zhang SL, He X, Yang XL, Wu HT, Lin BQ, Jiang CP, Wang J, Yu CH, Yang ZL, Wang CZ, Li P, Yuan CS. Antioxidant effects of Genkwa flos flavonoids on Freund?s adjuvant-induced rheumatoid arthritis in rats. J Ethnopharmacol. 2014 May 14; 153(3):793-800. PMID: 24685587.
      Citations: 15     Fields:    Translation:Animals
    23. Lian F, Li G, Chen X, Wang X, Piao C, Wang J, Hong Y, Ba Z, Wu S, Zhou X, Lang J, Liu Y, Zhang R, Hao J, Zhu Z, Li H, Fang Liu H, Cao A, Yan Z, An Y, Bai Y, Wang Q, Zhen Z, Yu C, Wang CZ, Yuan CS, Tong X. Chinese herbal medicine Tianqi reduces progression from impaired glucose tolerance to diabetes: a double-blind, randomized, placebo-controlled, multicenter trial. J Clin Endocrinol Metab. 2014 Feb; 99(2):648-55. PMID: 24432995.
      Citations: 41     Fields:    Translation:Humans
    24. Wang CZ, Zhang Z, Anderson S, Yuan CS. Natural products and chemotherapeutic agents on cancer: prevention vs. treatment. Am J Chin Med. 2014; 42(6):1555-8. PMID: 25482675.
      Citations: 13     Fields:    Translation:HumansAnimals
    25. Tung NH, Du GJ, Yuan CS, Shoyama Y, Wang CZ. Isolation and chemopreventive evaluation of novel naphthoquinone compounds from Alkanna tinctoria. Anticancer Drugs. 2013 Nov; 24(10):1058-68. PMID: 24025561; PMCID: PMC3882009.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    26. Wen XD, Wang CZ, Yu C, Zhao L, Zhang Z, Matin A, Wang Y, Li P, Xiao SY, Du W, He TC, Yuan CS. Panax notoginseng attenuates experimental colitis in the azoxymethane/dextran sulfate sodium mouse model. Phytother Res. 2014 Jun; 28(6):892-8. PMID: 24142591; PMCID: PMC3994185.
      Citations: 17     Fields:    Translation:Animals
    27. Wang CZ, Yuan CS. Pharmacologic treatment of opioid-induced constipation. Expert Opin Investig Drugs. 2013 Oct; 22(10):1225-7. PMID: 23834367.
      Citations: 5     Fields:    Translation:Humans
    28. Yu CH, Wang CZ, Yuan CS. [Progress in anti-cancer research of American ginseng: with an example of colorectal cancer]. Yao Xue Xue Bao. 2013 Jul; 48(7):986-92. PMID: 24133965.
      Citations:    Fields:    Translation:HumansAnimals
    29. Wang CZ, Zhang Z, Huang WH, Du GJ, Wen XD, Calway T, Yu C, Nass R, Zhao J, Du W, Li SP, Yuan CS. Identification of potential anticancer compounds from Oplopanax horridus. Phytomedicine. 2013 Aug 15; 20(11):999-1006. PMID: 23746754; PMCID: PMC3729876.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    30. Zhang Z, Wang CZ, Du GJ, Qi LW, Calway T, He TC, Du W, Yuan CS. Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells. Int J Oncol. 2013 Jul; 43(1):289-96. PMID: 23686257; PMCID: PMC3742162.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    31. Zhang Z, Wang CZ, Wen XD, Shoyama Y, Yuan CS. Role of saffron and its constituents on cancer chemoprevention. Pharm Biol. 2013 Jul; 51(7):920-4. PMID: 23570520; PMCID: PMC3971062.
      Citations: 22     Fields:    Translation:HumansAnimals
    32. Zhang Z, Du GJ, Wang CZ, Wen XD, Calway T, Li Z, He TC, Du W, Bissonnette M, Musch MW, Chang EB, Yuan CS. Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions. Int J Mol Sci. 2013 Jan 31; 14(2):2980-95. PMID: 23434653; PMCID: PMC3588026.
      Citations: 38     Fields:    
    33. Wang CZ, Calway TD, Wen XD, Smith J, Yu C, Wang Y, Mehendale SR, Yuan CS. Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway. Int J Oncol. 2013 Mar; 42(3):1018-26. PMID: 23337959; PMCID: PMC3576930.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    34. Wang CZ, Li B, Wen XD, Zhang Z, Yu C, Calway TD, He TC, Du W, Yuan CS. Paraptosis and NF-?B activation are associated with protopanaxadiol-induced cancer chemoprevention. BMC Complement Altern Med. 2013 Jan 03; 13:2. PMID: 23281928; PMCID: PMC3575249.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    35. Wen XD, Wang CZ, Yu C, Zhang Z, Calway T, Wang Y, Li P, Yuan CS. Salvia miltiorrhiza (dan shen) significantly ameliorates colon inflammation in dextran sulfate sodium induced colitis. Am J Chin Med. 2013; 41(5):1097-108. PMID: 24117071; PMCID: PMC3971063.
      Citations: 19     Fields:    Translation:Animals
    36. Li Z, Zhang Z, Li Y, Arnovitz S, Chen P, Huang H, Jiang X, Hong GM, Kunjamma RB, Ren H, He C, Wang CZ, Elkahloun AG, Valk PJ, Neilly MB, Bullinger L, Delwel R, Liu PP, Morgan R, Rowley JD, Yuan CS, Chen J, Döhner K, Löwenberg B. PBX3 is an important cofactor of HOXA9 in leukemogenesis. Blood. 2013 Feb 21; 121(8):1422-31. PMID: 23264595; PMCID: PMC3578957.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    37. Du GJ, Zhang Z, Wen XD, Yu C, Calway T, Yuan CS, Wang CZ. Epigallocatechin Gallate (EGCG) is the most effective cancer chemopreventive polyphenol in green tea. Nutrients. 2012 Nov 08; 4(11):1679-91. PMID: 23201840; PMCID: PMC3509513.
      Citations: 161     Fields:    Translation:HumansCells
    38. Jin HR, Zhao J, Zhang Z, Liao Y, Wang CZ, Huang WH, Li SP, He TC, Yuan CS, Du W. The antitumor natural compound falcarindiol promotes cancer cell death by inducing endoplasmic reticulum stress. Cell Death Dis. 2012 Aug 23; 3:e376. PMID: 22914324; PMCID: PMC3434669.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    39. Du GJ, Wang CZ, Qi LW, Zhang ZY, Calway T, He TC, Du W, Yuan CS. The synergistic apoptotic interaction of panaxadiol and epigallocatechin gallate in human colorectal cancer cells. Phytother Res. 2013 Feb; 27(2):272-7. PMID: 22566066; PMCID: PMC3416950.
      Citations: 16     Fields:    Translation:HumansCells
    40. Wen XD, Yang J, Ma RH, Gao W, Qi LW, Li P, Bauer BA, Du GJ, Zhang Z, Somogyi J, Wang CZ, Yuan CS. Analysis of Panax notoginseng metabolites in rat bile by liquid chromatography-quadrupole time-of-flight mass spectrometry with microdialysis sampling. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 May 01; 895-896:162-8. PMID: 22465198; PMCID: PMC3336018.
      Citations: 5     Fields:    Translation:Animals
    41. Wang CZ, Du GJ, Zhang Z, Wen XD, Calway T, Zhen Z, Musch MW, Bissonnette M, Chang EB, Yuan CS. Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer. Int J Oncol. 2012 Jun; 40(6):1970-6. PMID: 22426808; PMCID: PMC3349346.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    42. Du GJ, Wang CZ, Zhang ZY, Wen XD, Somogyi J, Calway T, He TC, Du W, Yuan CS. Caspase-mediated pro-apoptotic interaction of panaxadiol and irinotecan in human colorectal cancer cells. J Pharm Pharmacol. 2012 May; 64(5):727-34. PMID: 22471369; PMCID: PMC3349342.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    43. Wang CZ, Calway T, Yuan CS. Herbal medicines as adjuvants for cancer therapeutics. Am J Chin Med. 2012; 40(4):657-69. PMID: 22809022; PMCID: PMC3415888.
      Citations: 46     Fields:    Translation:HumansCells
    44. Wang CZ, He H, Wang X, Yuan CS. Trends in scientific publications of Chinese medicine. Am J Chin Med. 2012; 40(6):1099-108. PMID: 23227784.
      Citations: 6     Fields:    
    45. Calway T, Du GJ, Wang CZ, Huang WH, Zhao J, Li SP, Yuan CS. Chemical and pharmacological studies of Oplopanax horridus, a North American botanical. J Nat Med. 2012 Apr; 66(2):249-56. PMID: 22101399; PMCID: PMC3345165.
      Citations: 11     Fields:    Translation:HumansAnimals
    46. Dougherty U, Mustafi R, Wang Y, Musch MW, Wang CZ, Konda VJ, Kulkarni A, Hart J, Dawson G, Kim KE, Yuan CS, Chang EB, Bissonnette M. American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR. BMC Complement Altern Med. 2011 Nov 09; 11:111. PMID: 22070864; PMCID: PMC3227598.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    47. Qi LW, Wang CZ, Du GJ, Zhang ZY, Calway T, Yuan CS. Metabolism of ginseng and its interactions with drugs. Curr Drug Metab. 2011 Nov; 12(9):818-22. PMID: 21619519; PMCID: PMC3291795.
      Citations: 36     Fields:    Translation:HumansAnimals
    48. Chang WT, Li J, Haung HH, Liu H, Han M, Ramachandran S, Li CQ, Sharp WW, Hamann KJ, Yuan CS, Hoek TL, Shao ZH. Baicalein protects against doxorubicin-induced cardiotoxicity by attenuation of mitochondrial oxidant injury and JNK activation. J Cell Biochem. 2011 Oct; 112(10):2873-81. PMID: 21618589; PMCID: PMC3178681.
      Citations: 27     Fields:    Translation:AnimalsCells
    49. Sun S, Qi LW, Du GJ, Mehendale SR, Wang CZ, Yuan CS. Red notoginseng: higher ginsenoside content and stronger anticancer potential than Asian and American ginseng. Food Chem. 2011 Apr 15; 125(4):1299-1305. PMID: 21344064; PMCID: PMC3041968.
      Citations: 49     Fields:    
    50. Xie JT, Du GJ, McEntee E, Aung HH, He H, Mehendale SR, Wang CZ, Yuan CS. Effects of Triterpenoid Glycosides from Fresh Ginseng Berry on SW480 Human Colorectal Cancer Cell Line. Cancer Res Treat. 2011 Mar; 43(1):49-55. PMID: 21509163; PMCID: PMC3072535.
      Citations: 5     Fields:    
    51. Qi LW, Wang CZ, Yuan CS. Ginsenosides from American ginseng: chemical and pharmacological diversity. Phytochemistry. 2011 Jun; 72(8):689-99. PMID: 21396670; PMCID: PMC3103855.
      Citations: 118     Fields:    Translation:AnimalsCells
    52. Yuan CS, Tanaka H. Bioactivity of American ginseng by knockout extract preparation using monoclonal antibody. Curr Drug Discov Technol. 2011 Mar; 8(1):32-41. PMID: 21143131.
      Citations: 6     Fields:    Translation:Animals
    53. Qi LW, Wang CZ, Yuan CS. Isolation and analysis of ginseng: advances and challenges. Nat Prod Rep. 2011 Mar; 28(3):467-95. PMID: 21258738; PMCID: PMC3056508.
      Citations: 116     Fields:    Translation:AnimalsCells
    54. Du GJ, Dai Q, Williams S, Wang CZ, Yuan CS. Synthesis of protopanaxadiol derivatives and evaluation of their anticancer activities. Anticancer Drugs. 2011 Jan; 22(1):35-45. PMID: 20926945; PMCID: PMC2992804.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    55. Wang CZ, Mehendale SR, Calway T, Yuan CS. Botanical flavonoids on coronary heart disease. Am J Chin Med. 2011; 39(4):661-71. PMID: 21721147; PMCID: PMC3277260.
      Citations: 26     Fields:    Translation:HumansAnimals
    56. Wang CZ, Kim KE, Du GJ, Qi LW, Wen XD, Li P, Bauer BA, Bissonnette MB, Musch MW, Chang EB, Yuan CS. Ultra-performance liquid chromatography and time-of-flight mass spectrometry analysis of ginsenoside metabolites in human plasma. Am J Chin Med. 2011; 39(6):1161-71. PMID: 22083988; PMCID: PMC3246195.
      Citations: 27     Fields:    Translation:HumansAnimalsCTClinical Trials
    57. Li B, Zhao J, Wang CZ, Searle J, He TC, Yuan CS, Du W. Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53. Cancer Lett. 2011 Feb 28; 301(2):185-92. PMID: 21194832; PMCID: PMC3022099.
      Citations: 110     Fields:    Translation:HumansCells
    58. Yuan CS, Wang CZ, Wicks SM, Qi LW. Chemical and pharmacological studies of saponins with a focus on American ginseng. J Ginseng Res. 2010 Sep 01; 34(3):160-7. PMID: 21359120; PMCID: PMC3043615.
      Citations: 73     
    59. Sun S, Du GJ, Qi LW, Williams S, Wang CZ, Yuan CS. Hydrophobic constituents and their potential anticancer activities from Devil's Club (Oplopanax horridus Miq.). J Ethnopharmacol. 2010 Oct 28; 132(1):280-5. PMID: 20723598; PMCID: PMC3050531.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    60. Sun S, Li XL, Wang CZ, Williams S, Yuan CS. Improving anticancer activities of Oplopanax horridus root bark extract by removing water-soluble components. Phytother Res. 2010 Aug; 24(8):1166-74. PMID: 20077432; PMCID: PMC3057089.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    61. Qi LW, Wang CZ, Yuan CS. American ginseng: potential structure-function relationship in cancer chemoprevention. Biochem Pharmacol. 2010 Oct 01; 80(7):947-54. PMID: 20599804.
      Citations: 102     Fields:    Translation:HumansAnimals
    62. Li XL, Sun S, Du GJ, Qi LW, Williams S, Wang CZ, Yuan CS. Effects of Oplopanax horridus on human colorectal cancer cells. Anticancer Res. 2010 Feb; 30(2):295-302. PMID: 20332432; PMCID: PMC3057088.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    63. Wang CZ, Li XL, Wang QF, Mehendale SR, Yuan CS. Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells. Phytomedicine. 2010 Jan; 17(1):63-8. PMID: 19836937; PMCID: PMC2789205.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    64. Yuan CS, Sun S, Attele A, Wang CZ, Tong R, Israel RJ. Methylnaltrexone potentiates body weight and fat reduction with leptin. J Opioid Manag. 2009 Nov-Dec; 5(6):373-8. PMID: 20073411.
      Citations: 2     Fields:    Translation:Animals
    65. Li XL, Wang CZ, Sun S, Mehendale SR, Du W, He TC, Yuan CS. American ginseng berry enhances chemopreventive effect of 5-FU on human colorectal cancer cells. Oncol Rep. 2009 Oct; 22(4):943-52. PMID: 19724877.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    66. Xie JT, Wang CZ, Zhang B, Mehendale SR, Li XL, Sun S, Han AH, Du W, He TC, Yuan CS. In vitro and in vivo anticancer effects of American ginseng berry: exploring representative compounds. Biol Pharm Bull. 2009 Sep; 32(9):1552-8. PMID: 19721231.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    67. Li B, Wang CZ, He TC, Yuan CS, Du W. Antioxidants potentiate American ginseng-induced killing of colorectal cancer cells. Cancer Lett. 2010 Mar 01; 289(1):62-70. PMID: 19716228; PMCID: PMC2824022.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    68. Yuan CS, Wang CZ, Mehendale SR, Aung HH, Foo A, Israel RJ. Protease inhibitor-induced nausea and vomiting is attenuated by a peripherally acting, opioid-receptor antagonist in a rat model. AIDS Res Ther. 2009 Aug 21; 6:19. PMID: 19698111; PMCID: PMC2736972.
      Citations: 4     Fields:    
    69. Wang CZ, Aung HH, Mehendale SR, Shoyama Y, Yuan CS. High performance liquid chromatographic analysis and anticancer potential of Oplopanax horridus: comparison of stem and berry extracts. Fitoterapia. 2010 Mar; 81(2):132-9. PMID: 19686820; PMCID: PMC2814987.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    70. Wang CZ, Li XL, Sun S, Xie JT, Aung HH, Tong R, McEntee E, Yuan CS. Methylnaltrexone, a peripherally acting opioid receptor antagonist, enhances tumoricidal effects of 5-Fu on human carcinoma cells. Anticancer Res. 2009 Aug; 29(8):2927-32. PMID: 19661297.
      Citations: 14     Fields:    Translation:HumansCells
    71. Shao ZH, Wojcik KR, Dossumbekova A, Hsu C, Mehendale SR, Li CQ, Qin Y, Sharp WW, Chang WT, Hamann KJ, Yuan CS, Hoek TL. Grape seed proanthocyanidins protect cardiomyocytes from ischemia and reperfusion injury via Akt-NOS signaling. J Cell Biochem. 2009 Jul 01; 107(4):697-705. PMID: 19388003.
      Citations: 12     Fields:    Translation:AnimalsCells
    72. Yuan CS, Wang CZ, Attele A, Zhang L. Methylnaltrexone reduced body weight gain in ob/ob mice. J Opioid Manag. 2009 Jul-Aug; 5(4):213-8. PMID: 19736901.
      Citations: 5     Fields:    Translation:Animals
    73. Fishbein AB, Wang CZ, Li XL, Mehendale SR, Sun S, Aung HH, Yuan CS. Asian ginseng enhances the anti-proliferative effect of 5-fluorouracil on human colorectal cancer: comparison between white and red ginseng. Arch Pharm Res. 2009 Apr; 32(4):505-13. PMID: 19407967.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    74. Xie JT, Wang CZ, Li XL, Ni M, Fishbein A, Yuan CS. Anti-diabetic effect of American ginseng may not be linked to antioxidant activity: comparison between American ginseng and Scutellaria baicalensis using an ob/ob mice model. Fitoterapia. 2009 Jul; 80(5):306-11. PMID: 19358881.
      Citations: 5     Fields:    Translation:Animals
    75. Wang CZ, Ni M, Sun S, Li XL, He H, Mehendale SR, Yuan CS. Detection of adulteration of notoginseng root extract with other panax species by quantitative HPLC coupled with PCA. J Agric Food Chem. 2009 Mar 25; 57(6):2363-7. PMID: 19256509; PMCID: PMC2705280.
      Citations: 23     Fields:    Translation:AnimalsPHPublic Health
    76. Li XL, Wang CZ, Mehendale SR, Sun S, Wang Q, Yuan CS. Panaxadiol, a purified ginseng component, enhances the anti-cancer effects of 5-fluorouracil in human colorectal cancer cells. Cancer Chemother Pharmacol. 2009 Nov; 64(6):1097-104. PMID: 19277659.
      Citations: 24     Fields:    Translation:HumansCells
    77. Wang CZ, Li XL, Wang QF, Mehendale SR, Fishbein AB, Han AH, Sun S, Yuan CS. The mitochondrial pathway is involved in American ginseng-induced apoptosis of SW-480 colon cancer cells. Oncol Rep. 2009 Mar; 21(3):577-84. PMID: 19212614; PMCID: PMC2676877.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    78. Wang CZ, Xie JT, Fishbein A, Aung HH, He H, Mehendale SR, He TC, Du W, Yuan CS. Antiproliferative effects of different plant parts of Panax notoginseng on SW480 human colorectal cancer cells. Phytother Res. 2009 Jan; 23(1):6-13. PMID: 19048608; PMCID: PMC2676878.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    79. Woo M, O'Connor M, Yuan CS, Moss J. Reversal of opioid-induced gastric dysfunction in a critically ill burn patient after methylnaltrexone. Anesth Analg. 2008 Dec; 107(6):1965-7. PMID: 19020145.
      Citations: 6     Fields:    Translation:Humans
    80. Wang CZ, Aung HH, Zhang B, Sun S, Li XL, He H, Xie JT, He TC, Du W, Yuan CS. Chemopreventive effects of heat-processed Panax quinquefolius root on human breast cancer cells. Anticancer Res. 2008 Sep-Oct; 28(5A):2545-51. PMID: 19035277; PMCID: PMC2676904.
      Citations: 38     Fields:    Translation:HumansAnimals
    81. Luo X, Wang CZ, Chen J, Song WX, Luo J, Tang N, He BC, Kang Q, Wang Y, Du W, He TC, Yuan CS. Characterization of gene expression regulated by American ginseng and ginsenoside Rg3 in human colorectal cancer cells. Int J Oncol. 2008 May; 32(5):975-83. PMID: 18425323; PMCID: PMC2677725.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    82. Wang CZ, Yuan CS. Potential role of ginseng in the treatment of colorectal cancer. Am J Chin Med. 2008; 36(6):1019-28. PMID: 19051332; PMCID: PMC2676850.
      Citations: 39     Fields:    Translation:HumansAnimals
    83. Lin E, Wang Y, Mehendale S, Sun S, Wang CZ, Xie JT, Aung HH, Yuan CS. Antioxidant protection by American ginseng in pancreatic beta-cells. Am J Chin Med. 2008; 36(5):981-8. PMID: 19051362; PMCID: PMC2676842.
      Citations: 9     Fields:    Translation:AnimalsCells
    84. Wang CZ, Xie JT, Zhang B, Ni M, Fishbein A, Aung HH, Mehendale SR, Du W, He TC, Yuan CS. Chemopreventive effects of Panax notoginseng and its major constituents on SW480 human colorectal cancer cells. Int J Oncol. 2007 Nov; 31(5):1149-56. PMID: 17912442; PMCID: PMC2676859.
      Citations: 29     Fields:    Translation:HumansCells
    85. Mehendale S, Aung H, Wang CZ, Tong R, Foo A, Xie JT, Yuan CS. Scutellaria baicalensis and a constituent flavonoid, baicalein, attenuate ritonavir-induced gastrointestinal side-effects. J Pharm Pharmacol. 2007 Nov; 59(11):1567-72. PMID: 17976269; PMCID: PMC2676851.
      Citations: 14     Fields:    Translation:Animals
    86. Aung HH, Wang CZ, Ni M, Fishbein A, Mehendale SR, Xie JT, Shoyama CY, Yuan CS. Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells. Exp Oncol. 2007 Sep; 29(3):175-80. PMID: 18004240; PMCID: PMC2658895.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    87. Wang CZ, Aung HH, Ni M, Wu JA, Tong R, Wicks S, He TC, Yuan CS. Red American ginseng: ginsenoside constituents and antiproliferative activities of heat-processed Panax quinquefolius roots. Planta Med. 2007 Jun; 73(7):669-74. PMID: 17538869; PMCID: PMC2657361.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    88. Yuan CS. Methylnaltrexone mechanisms of action and effects on opioid bowel dysfunction and other opioid adverse effects. Ann Pharmacother. 2007 Jun; 41(6):984-93. PMID: 17504835.
      Citations: 9     Fields:    Translation:Humans
    89. Chang WT, Shao ZH, Yin JJ, Mehendale S, Wang CZ, Qin Y, Li J, Chen WJ, Chien CT, Becker LB, Vanden Hoek TL, Yuan CS. Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes. Eur J Pharmacol. 2007 Jul 02; 566(1-3):58-66. PMID: 17475241; PMCID: PMC2657475.
      Citations: 33     Fields:    Translation:AnimalsCells
    90. Wicks SM, Tong R, Wang CZ, O'Connor M, Karrison T, Li S, Moss J, Yuan CS. Safety and tolerability of Ganoderma lucidum in healthy subjects: a double-blind randomized placebo-controlled trial. Am J Chin Med. 2007; 35(3):407-14. PMID: 17597499.
      Citations: 8     Fields:    Translation:HumansAnimals
    91. Wang CZ, Mehendale SR, Yuan CS. Commonly used antioxidant botanicals: active constituents and their potential role in cardiovascular illness. Am J Chin Med. 2007; 35(4):543-58. PMID: 17708622; PMCID: PMC2657364.
      Citations: 50     Fields:    Translation:HumansAnimals
    92. Wang CZ, Zhang B, Song WX, Wang A, Ni M, Luo X, Aung HH, Xie JT, Tong R, He TC, Yuan CS. Steamed American ginseng berry: ginsenoside analyses and anticancer activities. J Agric Food Chem. 2006 Dec 27; 54(26):9936-42. PMID: 17177524.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    93. Mehendale SR, Wang CZ, Shao ZH, Li CQ, Xie JT, Aung HH, Yuan CS. Chronic pretreatment with American ginseng berry and its polyphenolic constituents attenuate oxidant stress in cardiomyocytes. Eur J Pharmacol. 2006 Dec 28; 553(1-3):209-14. PMID: 17092497.
      Citations: 14     Fields:    Translation:AnimalsCells
    94. Wang CZ, Luo X, Zhang B, Song WX, Ni M, Mehendale S, Xie JT, Aung HH, He TC, Yuan CS. Notoginseng enhances anti-cancer effect of 5-fluorouracil on human colorectal cancer cells. Cancer Chemother Pharmacol. 2007 Jun; 60(1):69-79. PMID: 17009031; PMCID: PMC2657471.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    95. Aung HH, Mehendale SR, Wang CZ, Xie JT, McEntee E, Yuan CS. Cisplatin's tumoricidal effect on human breast carcinoma MCF-7 cells was not attenuated by American ginseng. Cancer Chemother Pharmacol. 2007 Feb; 59(3):369-74. PMID: 16799811; PMCID: PMC2651154.
      Citations: 14     Fields:    Translation:HumansAnimals
    96. Yuan CS, Israel RJ. Methylnaltrexone, a novel peripheral opioid receptor antagonist for the treatment of opioid side effects. Expert Opin Investig Drugs. 2006 May; 15(5):541-52. PMID: 16634692.
      Citations: 13     Fields:    Translation:HumansAnimals
    97. Wang CZ, Wu JA, McEntee E, Yuan CS. Saponins composition in American ginseng leaf and berry assayed by high-performance liquid chromatography. J Agric Food Chem. 2006 Mar 22; 54(6):2261-6. PMID: 16536605.
      Citations: 35     Fields:    Translation:Animals
    98. Xie JT, Wang CZ, Wicks S, Yin JJ, Kong J, Li J, Li YC, Yuan CS. Ganoderma lucidum extract inhibits proliferation of SW 480 human colorectal cancer cells. Exp Oncol. 2006 Mar; 28(1):25-9. PMID: 16614703.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    99. Xie JT, Shao ZH, Vanden Hoek TL, Chang WT, Li J, Mehendale S, Wang CZ, Hsu CW, Becker LB, Yin JJ, Yuan CS. Antioxidant effects of ginsenoside Re in cardiomyocytes. Eur J Pharmacol. 2006 Feb 27; 532(3):201-7. PMID: 16497296.
      Citations: 66     Fields:    Translation:AnimalsCells
    100. Mehendale SR, Yuan CS. Opioid-induced gastrointestinal dysfunction. Dig Dis. 2006; 24(1-2):105-12. PMID: 16699269.
      Citations: 19     Fields:    Translation:HumansAnimals
    101. Xie JT, Chang WT, Wang CZ, Mehendale SR, Li J, Ambihaipahar R, Ambihaipahar U, Fong HH, Yuan CS. Curry leaf (Murraya koenigii Spreng.) reduces blood cholesterol and glucose levels in ob/ob mice. Am J Chin Med. 2006; 34(2):279-84. PMID: 16552838.
      Citations: 6     Fields:    Translation:Animals
    102. Aung H, Mehendale S, Chang WT, Wang CZ, Xie JT, Yuan CS. Scutellaria baicalensis decreases ritonavir-induced nausea. AIDS Res Ther. 2005 Dec 20; 2:12. PMID: 16368007; PMCID: PMC1352373.
      Citations: 5     Fields:    
    103. Wang CZ, Fishbein A, Aung HH, Mehendale SR, Chang WT, Xie JT, Li J, Yuan CS. Polyphenol contents in grape-seed extracts correlate with antipica effects in cisplatin-treated rats. J Altern Complement Med. 2005 Dec; 11(6):1059-65. PMID: 16398598.
      Citations: 10     Fields:    Translation:Animals
    104. Xie JT, Wang CZ, Wang AB, Wu J, Basila D, Yuan CS. Antihyperglycemic effects of total ginsenosides from leaves and stem of Panax ginseng. Acta Pharmacol Sin. 2005 Sep; 26(9):1104-10. PMID: 16115378.
      Citations: 25     Fields:    Translation:Animals
    105. Wang A, Wang CZ, Wu JA, Osinski J, Yuan CS. Determination of major ginsenosides in Panax quinquefolius (American ginseng) using high-performance liquid chromatography. Phytochem Anal. 2005 Jul-Aug; 16(4):272-7. PMID: 16042154.
      Citations: 36     Fields:    Translation:Animals
    106. Yuan CS, Doshan H, Charney MR, O'connor M, Karrison T, Maleckar SA, Israel RJ, Moss J. Tolerability, gut effects, and pharmacokinetics of methylnaltrexone following repeated intravenous administration in humans. J Clin Pharmacol. 2005 May; 45(5):538-46. PMID: 15831777.
      Citations: 22     Fields:    Translation:HumansCTClinical Trials
    107. Mehendale S, Aung H, Wang A, Yin JJ, Wang CZ, Xie JT, Yuan CS. American ginseng berry extract and ginsenoside Re attenuate cisplatin-induced kaolin intake in rats. Cancer Chemother Pharmacol. 2005 Jul; 56(1):63-9. PMID: 15791456.
      Citations: 24     Fields:    Translation:Animals
    108. Basila D, Yuan CS. Effects of dietary supplements on coagulation and platelet function. Thromb Res. 2005; 117(1-2):49-53; discussion 65-7. PMID: 15913714.
      Citations: 6     Fields:    Translation:HumansAnimals
    109. Xie JT, Mchendale S, Yuan CS. Ginseng and diabetes. Am J Chin Med. 2005; 33(3):397-404. PMID: 16047557.
      Citations: 49     Fields:    Translation:HumansAnimals
    110. Wang CZ, Basila D, Aung HH, Mehendale SR, Chang WT, McEntee E, Guan X, Yuan CS. Effects of ganoderma lucidum extract on chemotherapy-induced nausea and vomiting in a rat model. Am J Chin Med. 2005; 33(5):807-15. PMID: 16265993.
      Citations: 18     Fields:    Translation:Animals
    111. Xie JT, Mehendale SR, Li X, Quigg R, Wang X, Wang CZ, Wu JA, Aung HH, A Rue P, Bell GI, Yuan CS. Anti-diabetic effect of ginsenoside Re in ob/ob mice. Biochim Biophys Acta. 2005 Jun 10; 1740(3):319-25. PMID: 15949698.
      Citations: 53     Fields:    Translation:Animals
    112. Yuan CS, Mehendale SR, Wang CZ, Aung HH, Jiang T, Guan X, Shoyama Y. Effects of Corydalis yanhusuo and Angelicae dahuricae on cold pressor-induced pain in humans: a controlled trial. J Clin Pharmacol. 2004 Nov; 44(11):1323-7. PMID: 15496650.
      Citations: 22     Fields:    Translation:HumansAnimalsCTClinical Trials
    113. Yuan CS, Wei G, Dey L, Karrison T, Nahlik L, Maleckar S, Kasza K, Ang-Lee M, Moss J. Brief communication: American ginseng reduces warfarin's effect in healthy patients: a randomized, controlled Trial. Ann Intern Med. 2004 Jul 06; 141(1):23-7. PMID: 15238367.
      Citations: 54     Fields:    Translation:HumansAnimalsCTClinical Trials
    114. Aung HH, Mehendale SR, Xie JT, Moss J, Yuan CS. Methylnaltrexone prevents morphine-induced kaolin intake in the rat. Life Sci. 2004 Apr 16; 74(22):2685-91. PMID: 15043984.
      Citations: 13     Fields:    Translation:Animals
    115. Mehendale S, Xie JT, Aung HH, Guan XF, Yuan CS. Nucleus accumbens receives gastric vagal inputs. Acta Pharmacol Sin. 2004 Mar; 25(3):271-5. PMID: 15000876.
      Citations: 4     Fields:    Translation:AnimalsCells
    116. Yuan CS. Clinical status of methylnaltrexone, a new agent to prevent and manage opioid-induced side effects. J Support Oncol. 2004 Mar-Apr; 2(2):111-7; discussion 119-22. PMID: 15328815.
      Citations: 10     Fields:    Translation:HumansAnimals
    117. Shao ZH, Xie JT, Vanden Hoek TL, Mehendale S, Aung H, Li CQ, Qin Y, Schumacker PT, Becker LB, Yuan CS. Antioxidant effects of American ginseng berry extract in cardiomyocytes exposed to acute oxidant stress. Biochim Biophys Acta. 2004 Feb 24; 1670(3):165-71. PMID: 14980443.
      Citations: 29     Fields:    Translation:AnimalsCells
    118. Xie JT, Wu JA, Mehendale S, Aung HH, Yuan CS. Anti-hyperglycemic effect of the polysaccharides fraction from American ginseng berry extract in ob/ob mice. Phytomedicine. 2004 Feb; 11(2-3):182-7. PMID: 15070170.
      Citations: 23     Fields:    Translation:Animals
    119. Mehendale S, Xiao Y, Aung HH, Xie JT, Ang-Lee MK, Yuan CS. The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. Anesth Analg. 2004 Feb; 98(2):353-358. PMID: 14742369.
      Citations: 26     Fields:    Translation:AnimalsCells
    120. Xie JT, Mehendale SR, Wang A, Han AH, Wu JA, Osinski J, Yuan CS. American ginseng leaf: ginsenoside analysis and hypoglycemic activity. Pharmacol Res. 2004 Feb; 49(2):113-7. PMID: 14643691.
      Citations: 29     Fields:    Translation:Animals
    121. Mehendale SR, Bauer BA, Yuan CS. Ephedra-containing dietary supplements in the US versus ephedra as a Chinese medicine. Am J Chin Med. 2004; 32(1):1-10. PMID: 15154280.
      Citations: 7     Fields:    Translation:HumansAnimals
    122. Shao ZH, Vanden Hoek TL, Li CQ, Schumacker PT, Becker LB, Chan KC, Qin Y, Yin JJ, Yuan CS. Synergistic effect of Scutellaria baicalensis and grape seed proanthocyanidins on scavenging reactive oxygen species in vitro. Am J Chin Med. 2004; 32(1):89-95. PMID: 15154288.
      Citations: 8     Fields:    Translation:HumansAnimals
    123. Aung HH, Dey L, Rand V, Yuan CS. Alternative therapies for male and female sexual dysfunction. Am J Chin Med. 2004; 32(2):161-73. PMID: 15315255.
      Citations: 8     Fields:    Translation:Humans
    124. Mehendale SR, Aung HH, Yin JJ, Lin E, Fishbein A, Wang CZ, Xie JT, Yuan CS. Effects of antioxidant herbs on chemotherapy-induced nausea and vomiting in a rat-pica model. Am J Chin Med. 2004; 32(6):897-905. PMID: 15673195.
      Citations: 13     Fields:    Translation:Animals
    125. Aung HH, Dey L, Mehendale S, Xie JT, Wu JA, Yuan CS. Scutellaria baicalensis extract decreases cisplatin-induced pica in rats. Cancer Chemother Pharmacol. 2003 Dec; 52(6):453-8. PMID: 12942313.
      Citations: 16     Fields:    Translation:Animals
    126. Shao ZH, Becker LB, Vanden Hoek TL, Schumacker PT, Li CQ, Zhao D, Wojcik K, Anderson T, Qin Y, Dey L, Yuan CS. Grape seed proanthocyanidin extract attenuates oxidant injury in cardiomyocytes. Pharmacol Res. 2003 Jun; 47(6):463-9. PMID: 12741998.
      Citations: 15     Fields:    Translation:AnimalsCells
    127. Wei G, Moss J, Yuan CS. Opioid-induced immunosuppression: is it centrally mediated or peripherally mediated? Biochem Pharmacol. 2003 Jun 01; 65(11):1761-6. PMID: 12781327.
      Citations: 28     Fields:    
    128. Xie JT, Wang A, Mehendale S, Wu J, Aung HH, Dey L, Qiu S, Yuan CS. Anti-diabetic effects of Gymnema yunnanense extract. Pharmacol Res. 2003 Apr; 47(4):323-9. PMID: 12644390.
      Citations: 10     Fields:    Translation:Animals
    129. Attele AS, Mehendale S, Guan X, Dey L, Yuan CS. Analgesic effects of different acupoint stimulation frequencies in humans. Am J Chin Med. 2003; 31(1):157-62. PMID: 12723766.
      Citations: 2     Fields:    Translation:Humans
    130. Shao ZH, Vanden Hoek TL, Xie J, Wojcik K, Chan KC, Li CQ, Hamann K, Qin Y, Schumacker PT, Becker LB, Yuan CS. Grape seed proanthocyanidins induce pro-oxidant toxicity in cardiomyocytes. Cardiovasc Toxicol. 2003; 3(4):331-9. PMID: 14734830.
      Citations: 6     Fields:    Translation:AnimalsCells
    131. Yuan CS, Dey L, Wang A, Mehendale S, Xie JT, Aung HH, Ang-Lee MK. Kavalactones and dihydrokavain modulate GABAergic activity in a rat gastric-brainstem preparation. Planta Med. 2002 Dec; 68(12):1092-6. PMID: 12494336.
      Citations: 13     Fields:    Translation:Animals
    132. Osinski J, Wang A, Wu JA, Foss JF, Yuan CS. Determination of methylnaltrexone in clinical samples by solid-phase extraction and high-performance liquid chromatography for a pharmacokinetics study. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Nov 25; 780(2):251-9. PMID: 12401350.
      Citations: 2     Fields:    Translation:Humans
    133. Yuan CS, Attele AS, Dey L, Lynch JP, Guan X. Transcutaneous electrical acupoint stimulation potentiates analgesic effect of morphine. J Clin Pharmacol. 2002 Aug; 42(8):899-903. PMID: 12162472.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    134. Attele AS, Zhou YP, Xie JT, Wu JA, Zhang L, Dey L, Pugh W, Rue PA, Polonsky KS, Yuan CS. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes. 2002 Jun; 51(6):1851-8. PMID: 12031973.
      Citations: 154     Fields:    Translation:Animals
    135. Attele AS, Shi ZQ, Yuan CS. Leptin, gut, and food intake. Biochem Pharmacol. 2002 May 01; 63(9):1579-83. PMID: 12007560.
      Citations: 17     Fields:    Translation:HumansAnimals
    136. Yuan CS, Dey L, Xie JT, Aung HH. Gastric effects of galanin and its interaction with leptin on brainstem neuronal activity. J Pharmacol Exp Ther. 2002 May; 301(2):488-93. PMID: 11961047.
      Citations: 6     Fields:    Translation:AnimalsCells
    137. Xie JT, Zhou YP, Dey L, Attele AS, Wu JA, Gu M, Polonsky KS, Yuan CS. Ginseng berry reduces blood glucose and body weight in db/db mice. Phytomedicine. 2002 Apr; 9(3):254-8. PMID: 12046868.
      Citations: 30     Fields:    Translation:Animals
    138. Shao ZH, Vanden Hoek TL, Qin Y, Becker LB, Schumacker PT, Li CQ, Dey L, Barth E, Halpern H, Rosen GM, Yuan CS. Baicalein attenuates oxidant stress in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2002 Mar; 282(3):H999-H1006. PMID: 11834498.
      Citations: 43     Fields:    Translation:AnimalsCells
    139. Dey L, Attele AS, Yuan CS. Alternative therapies for type 2 diabetes. Altern Med Rev. 2002 Feb; 7(1):45-58. PMID: 11896745.
      Citations: 50     Fields:    Translation:Humans
    140. Xie JT, Aung HH, Wu JA, Attel AS, Yuan CS. Effects of American ginseng berry extract on blood glucose levels in ob/ob mice. Am J Chin Med. 2002; 30(2-3):187-94. PMID: 12230007.
      Citations: 13     Fields:    Translation:Animals
    141. Yuan CS, Wei G, Foss JF, O'Connor M, Karrison T, Osinski J. Effects of subcutaneous methylnaltrexone on morphine-induced peripherally mediated side effects: a double-blind randomized placebo-controlled trial. J Pharmacol Exp Ther. 2002 Jan; 300(1):118-23. PMID: 11752106.
      Citations: 27     Fields:    Translation:HumansCTClinical Trials
    142. Xie JT, Dey L, Yuan CS. Biphasic effect of cardiac glycosides on action potential duration in isolated Purkinje fibers. Pharmacol Toxicol. 2001 Sep; 89(3):145-8. PMID: 11589786.
      Citations:    Fields:    Translation:AnimalsCells
    143. Ang-Lee MK, Moss J, Yuan CS. Herbal medicines and perioperative care. JAMA. 2001 Jul 11; 286(2):208-16. PMID: 11448284.
      Citations: 134     Fields:    Translation:HumansAnimals
    144. Yuan CS, Wang X, Wu JA, Attele AS, Xie JT, Gu M. Effects of Panax quinquefolius L. on brainstem neuronal activities: comparison between Wisconsin-cultivated and Illinois-cultivated roots. Phytomedicine. 2001 May; 8(3):178-83. PMID: 11417910.
      Citations: 6     Fields:    Translation:AnimalsCells
    145. Xie JT, Dey L, Wu JA, Lowell TK, Yuan CS. Cardiac toxicity of resibufogenin: electrophysiological evidence. Acta Pharmacol Sin. 2001 Apr; 22(4):289-97. PMID: 11742580.
      Citations: 8     Fields:    Translation:HumansAnimals
    146. Liu D, Li B, Liu Y, Attele AS, Kyle JW, Yuan CS. Voltage-dependent inhibition of brain Na(+) channels by American ginseng. Eur J Pharmacol. 2001 Feb 09; 413(1):47-54. PMID: 11173062.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    147. Wu JA, Attele AS, Zhang L, Yuan CS. Anti-HIV activity of medicinal herbs: usage and potential development. Am J Chin Med. 2001; 29(1):69-81. PMID: 11321482.
      Citations: 27     Fields:    Translation:HumansAnimals
    148. Shao Z, Li C, Becker LB, Vanden Hoek TL, Schumacker PT, Attele AS, Zhang L, Xie J, Yuan C. Qian-Kun-Nin, a Chinese herbal medicine formulation, attenuates mitochondrial oxidant stress in cardiomyocytes. J Ethnopharmacol. 2001 Jan; 74(1):63-8. PMID: 11137349.
      Citations: 1     Fields:    Translation:AnimalsCells
    149. Yuan CS, Foss JF. Antagonism of gastrointestinal opioid effects. Reg Anesth Pain Med. 2000 Nov-Dec; 25(6):639-42. PMID: 11097674.
      Citations: 6     Fields:    Translation:Humans
    150. Xie JT, Lowell TK, Yuan CS. Extracellular detection of delayed afterdepolarization of cardiac fibers using signal averaging technique. Acta Pharmacol Sin. 2000 Nov; 21(11):977-85. PMID: 11501065.
      Citations:    Fields:    Translation:Animals
    151. Yuan CS, Attele AS, Dey L, Xie JT. Gastric effects of cholecystokinin and its interaction with leptin on brainstem neuronal activity in neonatal rats. J Pharmacol Exp Ther. 2000 Oct; 295(1):177-82. PMID: 10991976.
      Citations: 7     Fields:    Translation:Animals
    152. Yuan CS, Attele AS, Zhang L, Lynch JP, Xie JT, Shi ZQ. Leptin reduces body weight gain in neonatal rats. Pediatr Res. 2000 Sep; 48(3):380-3. PMID: 10960507.
      Citations: 7     Fields:    Translation:Animals
    153. Attele AS, Xie JT, Yuan CS. Treatment of insomnia: an alternative approach. Altern Med Rev. 2000 Jun; 5(3):249-59. PMID: 10869104.
      Citations: 15     Fields:    Translation:Humans
    154. Yuan CS, Foss JF, O'Connor M, Karrison T, Osinski J, Roizen MF, Moss J. Effects of enteric-coated methylnaltrexone in preventing opioid-induced delay in oral-cecal transit time. Clin Pharmacol Ther. 2000 Apr; 67(4):398-404. PMID: 10801249.
      Citations: 14     Fields:    Translation:HumansCTClinical Trials
    155. Xie JT, Yuan CS, Zhou Z, January CT. Enhancement of delayed afterdepolarizations and triggered activity by class III antiarrhythmic drugs: multiple effects of E-4031 and dofetilide. Methods Find Exp Clin Pharmacol. 2000 Mar; 22(2):67-76. PMID: 10849888.
      Citations: 2     Fields:    Translation:Animals
    156. Yuan CS, Foss JF, O'Connor M, Osinski J, Karrison T, Moss J, Roizen MF. Methylnaltrexone for reversal of constipation due to chronic methadone use: a randomized controlled trial. JAMA. 2000 Jan 19; 283(3):367-72. PMID: 10647800.
      Citations: 47     Fields:    Translation:HumansCTClinical Trials
    157. Xie JT, Wang H, Attele AS, Yuan CS. Effects of resibufogenin from toad venom on isolated Purkinje fibers. Am J Chin Med. 2000; 28(2):187-96. PMID: 10999437.
      Citations: 3     Fields:    Translation:Animals
    158. Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol. 1999 Dec 01; 58(11):1685-93. PMID: 10571242.
      Citations: 524     Fields:    Translation:HumansAnimalsCells
    159. Yuan SC, Foss FJ, O'Connor M, Osinski J, Roizen FM, Moss J. Effects of intravenous methylnaltrexone on opioid-induced gut motility and transit time changes in subjects receiving chronic methadone therapy: a pilot study. Pain. 1999 Dec; 83(3):631-635. PMID: 10568873.
      Citations: 14     Fields:    Translation:Humans
    160. Shao ZH, Li CQ, Vanden Hoek TL, Becker LB, Schumacker PT, Wu JA, Attele AS, Yuan CS. Extract from Scutellaria baicalensis Georgi attenuates oxidant stress in cardiomyocytes. J Mol Cell Cardiol. 1999 Oct; 31(10):1885-95. PMID: 10525426.
      Citations: 28     Fields:    Translation:AnimalsCells
    161. Yuan CS, Attele AS, Wu JA, Zhang L, Shi ZQ. Peripheral gastric leptin modulates brain stem neuronal activity in neonates. Am J Physiol. 1999 09; 277(3):G626-30. PMID: 10484388.
      Citations: 3     Fields:    Translation:AnimalsCells
    162. Yuan CS, Foss JF. Gastric effects of methylnaltrexone on mu, kappa, and delta opioid agonists induced brainstem unitary responses. Neuropharmacology. 1999 Mar; 38(3):425-32. PMID: 10219980.
      Citations: 7     Fields:    Translation:AnimalsCells
    163. Yuan CS, Attele AS, Wu JA, Lowell TK, Gu Z, Lin Y. Panax quinquefolium L. inhibits thrombin-induced endothelin release in vitro. Am J Chin Med. 1999; 27(3-4):331-8. PMID: 10592841.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    164. Yuan CS, Foss JF, O'Connor M, Roizen MF, Moss J. Effects of low-dose morphine on gastric emptying in healthy volunteers. J Clin Pharmacol. 1998 Nov; 38(11):1017-20. PMID: 9824782.
      Citations: 16     Fields:    Translation:HumansCTClinical Trials
    165. Yuan CS, Attele AS, Wu JA, Liu D. Modulation of American ginseng on brainstem GABAergic effects in rats. J Ethnopharmacol. 1998 Oct; 62(3):215-22. PMID: 9849631.
      Citations: 12     Fields:    Translation:Animals
    166. Yuan CS, Foss JF, O'Connor M, Osinski J, Roizen MF, Moss J. Efficacy of orally administered methylnaltrexone in decreasing subjective effects after intravenous morphine. Drug Alcohol Depend. 1998 Oct 01; 52(2):161-5. PMID: 9800145.
      Citations: 12     Fields:    Translation:HumansCTClinical Trials
    167. Yuan CS, Foss JF, O'Connor M, Moss J, Roizen MF. Gut motility and transit changes in patients receiving long-term methadone maintenance. J Clin Pharmacol. 1998 Oct; 38(10):931-5. PMID: 9807974.
      Citations: 12     Fields:    Translation:Humans
    168. Yuan CS, Liu D, Attele AS. GABAergic effects on nucleus tractus solitarius neurons receiving gastric vagal inputs. J Pharmacol Exp Ther. 1998 Aug; 286(2):736-41. PMID: 9694928.
      Citations: 3     Fields:    Translation:AnimalsCells
    169. Lipman NS, Wardrip CL, Yuan CS, Coventry S, Bunte RM, Li X. Familial megacecum and colon in the rat: a new model of gastrointestinal neuromuscular dysfunction. Lab Anim Sci. 1998 Jun; 48(3):243-52. PMID: 10090023.
      Citations: 5     Fields:    Translation:Animals
    170. Yuan CS, Karrison T, Wu JA, Lowell TK, Lynch JP, Foss JF. Dose-related effects of oral acetaminophen on cold-induced pain: a double-blind, randomized, placebo-controlled trial. Clin Pharmacol Ther. 1998 Mar; 63(3):379-83. PMID: 9542481.
      Citations: 6     Fields:    Translation:HumansCTClinical Trials
    171. Yuan CS, Wu JA, Lowell T, Gu M. Gut and brain effects of American ginseng root on brainstem neuronal activities in rats. Am J Chin Med. 1998; 26(1):47-55. PMID: 9592593.
      Citations: 7     Fields:    Translation:AnimalsCells
    172. Foss JF, Yuan CS, Roizen MF, Goldberg LI. Prevention of apomorphine- or cisplatin-induced emesis in the dog by a combination of methylnaltrexone and morphine. Cancer Chemother Pharmacol. 1998; 42(4):287-91. PMID: 9744773.
      Citations: 4     Fields:    Translation:Animals
    173. Yuan CS, Foss JF, Osinski J, Toledano A, Roizen MF, Moss J. The safety and efficacy of oral methylnaltrexone in preventing morphine-induced delay in oral-cecal transit time. Clin Pharmacol Ther. 1997 Apr; 61(4):467-75. PMID: 9129564.
      Citations: 26     Fields:    Translation:HumansCTClinical Trials
    174. Moss J, Yuan CS, Fatatis A, Attele A. Effects of histamine on intracellular calcium transients recorded with Fura-2 in renal pacemaker cells in guinea pig. Inflamm Res. 1997 Mar; 46 Suppl 1:S95-6. PMID: 9098783.
      Citations:    Fields:    Translation:Animals
    175. Moss J, Yuan CS, Fatatis A, Attele A. Effects of histamine on intracellular calcium transients recorded with Fura-2 in renal pacemaker cells in guinea pig. Inflamm Res. 1997 Mar; 46(Suppl 1):95-6. PMID: 27518021.
      Citations:    Fields:    
    176. Yuan CS, Lowell TK. Gastric and brain stem, effects of substance P on nucleus tractus solitarius unitary responses. Peptides. 1997; 18(8):1169-73. PMID: 9396057.
      Citations: 1     Fields:    Translation:AnimalsCells
    177. Foss JF, O'Connor MF, Yuan CS, Murphy M, Moss J, Roizen MF. Safety and tolerance of methylnaltrexone in healthy humans: a randomized, placebo-controlled, intravenous, ascending-dose, pharmacokinetic study. J Clin Pharmacol. 1997 Jan; 37(1):25-30. PMID: 9048269.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    178. Yuan CS. Gastric effects of mu-, delta- and kappa-opioid receptor agonists on brainstem unitary responses in the neonatal rat. Eur J Pharmacol. 1996 Oct 24; 314(1-2):27-32. PMID: 8957215.
      Citations: 2     Fields:    Translation:Animals
    179. Yuan CS, Foss JF, O'Connor M, Toledano A, Roizen MF, Moss J. Methylnaltrexone prevents morphine-induced delay in oral-cecal transit time without affecting analgesia: a double-blind randomized placebo-controlled trial. Clin Pharmacol Ther. 1996 Apr; 59(4):469-75. PMID: 8612393.
      Citations: 43     Fields:    Translation:HumansCTClinical Trials
    180. Yuan CS, Foss JF, Moss J. Effects of methylnaltrexone on morphine-induced inhibition of contraction in isolated guinea-pig ileum and human intestine. Eur J Pharmacol. 1995 Mar 24; 276(1-2):107-11. PMID: 7781680.
      Citations: 10     Fields:    Translation:HumansAnimals
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