Cholinesterase Inhibitors
"Cholinesterase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.
Descriptor ID |
D002800
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MeSH Number(s) |
D27.505.519.389.275 D27.505.519.625.120.300 D27.505.696.577.120.300
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Concept/Terms |
Cholinesterase Inhibitors- Cholinesterase Inhibitors
- Inhibitors, Cholinesterase
- Anticholinesterase Drugs
- Drugs, Anticholinesterase
- Anticholinesterases
- Anticholinesterase Agents
- Agents, Anticholinesterase
- Anti-Cholinesterases
- Anti Cholinesterases
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Below are MeSH descriptors whose meaning is more general than "Cholinesterase Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Cholinesterase Inhibitors".
This graph shows the total number of publications written about "Cholinesterase Inhibitors" by people in this website by year, and whether "Cholinesterase Inhibitors" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1991 | 1 | 3 | 4 | 1997 | 2 | 0 | 2 | 1999 | 0 | 1 | 1 | 2000 | 1 | 0 | 1 | 2001 | 0 | 1 | 1 | 2002 | 1 | 2 | 3 | 2003 | 2 | 0 | 2 | 2004 | 3 | 1 | 4 | 2005 | 1 | 2 | 3 | 2006 | 1 | 0 | 1 | 2007 | 0 | 1 | 1 | 2008 | 0 | 1 | 1 | 2010 | 1 | 0 | 1 | 2011 | 2 | 2 | 4 | 2013 | 1 | 1 | 2 | 2014 | 1 | 0 | 1 | 2018 | 0 | 1 | 1 | 2019 | 0 | 1 | 1 | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cholinesterase Inhibitors" by people in Profiles.
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Yuen C, Soliven B, Rezania K. ATM mutation in a patient with thymoma-associated myasthenia gravis. Muscle Nerve. 2020 08; 62(2):E50-E52.
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Yu L, Wei F, Liang J, Ren G, Liu X, Wang CZ, Yuan J, Zeng J, Luo Y, Bi Y, Yuan CS. Target Molecular-Based Neuroactivity Screening and Analysis of Panax ginseng by Affinity Ultrafiltration, UPLC-QTOF-MS and Molecular Docking. Am J Chin Med. 2019; 47(6):1345-1363.
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Murphy GS, Szokol JW, Avram MJ, Greenberg SB, Shear TD, Deshur MA, Benson J, Newmark RL, Maher CE. Neostigmine Administration after Spontaneous Recovery to a Train-of-Four Ratio of 0.9 to 1.0: A Randomized Controlled Trial of the Effect on Neuromuscular and Clinical Recovery. Anesthesiology. 2018 01; 128(1):27-37.
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Leikin JB, Braund V, DesLauris C. Cholinergic symptoms with low serum cholinesterase from therapeutic cholinesterase inhibitor toxicity. Am J Emerg Med. 2014 Jul; 32(7):815.e3-4.
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Huynh T, Sun B, Li L, Nichols KP, Koyner JL, Ismagilov RF. Chemical analog-to-digital signal conversion based on robust threshold chemistry and its evaluation in the context of microfluidics-based quantitative assays. J Am Chem Soc. 2013 Oct 02; 135(39):14775-83.
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Shaw KE, Bondi CO, Light SH, Massimino LA, McAloon RL, Monaco CM, Kline AE. Donepezil is ineffective in promoting motor and cognitive benefits after controlled cortical impact injury in male rats. J Neurotrauma. 2013 Apr 01; 30(7):557-64.
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Zhu H, Bhattacharyya BJ, Lin H, Gomez CM. Skeletal muscle IP3R1 receptors amplify physiological and pathological synaptic calcium signals. J Neurosci. 2011 Oct 26; 31(43):15269-83.
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Torres-Altoro MI, Mathur BN, Drerup JM, Thomas R, Lovinger DM, O'Callaghan JP, Bibb JA. Organophosphates dysregulate dopamine signaling, glutamatergic neurotransmission, and induce neuronal injury markers in striatum. J Neurochem. 2011 Oct; 119(2):303-13.
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Wang CZ, Du GJ, Zhen Z, Calway T, Yuan CS. Significant dose differences in donepezil purchased from the United States and Canada. Ann Intern Med. 2011 Aug 16; 155(4):279-80.
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Vellas B, Pesce A, Robert PH, Aisen PS, Ancoli-Israel S, Andrieu S, Cedarbaum J, Dubois B, Siemers E, Spire JP, Weiner MW, May TS. AMPA workshop on challenges faced by investigators conducting Alzheimer's disease clinical trials. Alzheimers Dement. 2011 Jul; 7(4):e109-17.
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