"Uncoupling Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.
| Descriptor ID |
D014475
|
| MeSH Number(s) |
D27.505.519.389.936
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Uncoupling Agents".
Below are MeSH descriptors whose meaning is more specific than "Uncoupling Agents".
This graph shows the total number of publications written about "Uncoupling Agents" by people in this website by year, and whether "Uncoupling Agents" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1997 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 1 | 1 | 2 |
| 2006 | 0 | 2 | 2 |
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Below are the most recent publications written about "Uncoupling Agents" by people in Profiles.
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Reactive species, cellular repair and risk factors in the onset of type 2 diabetes mellitus: review and hypothesis. Curr Diabetes Rev. 2006 May; 2(2):241-59.
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Antioxidant effects of ginsenoside Re in cardiomyocytes. Eur J Pharmacol. 2006 Feb 27; 532(3):201-7.
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Cellular remodeling in heart failure disrupts K(ATP) channel-dependent stress tolerance. EMBO J. 2003 Apr 15; 22(8):1732-42.
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Activation of mitochondrial ATP-sensitive potassium channels increases cell viability against rotenone-induced cell death. J Neurochem. 2003 Mar; 84(5):1193-200.
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Diversity in mitochondrial function explains differences in vascular oxygen sensing. Circ Res. 2002 Jun 28; 90(12):1307-15.
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Mitochondrial ROS initiate phosphorylation of p38 MAP kinase during hypoxia in cardiomyocytes. Am J Physiol Lung Cell Mol Physiol. 2002 Jun; 282(6):L1324-9.
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Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing. Circ Res. 2001 Jun 22; 88(12):1259-66.
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The pancreatic beta cell heats up: UCP2 and insulin secretion in diabetes. Cell. 2001 Jun 15; 105(6):705-7.
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Redox regulation of p53 during hypoxia. Oncogene. 2000 Aug 10; 19(34):3840-8.
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Role of oxidative metabolism on endothelium-dependent vascular relaxation of isolated vessels. J Mol Cell Cardiol. 1997 Mar; 29(3):871-9.