Catechol O-Methyltransferase Inhibitors
"Catechol O-Methyltransferase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds and drugs that inhibit or block the activity of CATECHOL O-METHYLTRANSFERASE enzymes. Drugs in this class are used in management of central nervous system disorders such as PARKINSON DISEASE.
| Descriptor ID |
D065098
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| MeSH Number(s) |
D27.505.519.389.237 D27.505.954.427.090.050.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Catechol O-Methyltransferase Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Catechol O-Methyltransferase Inhibitors".
This graph shows the total number of publications written about "Catechol O-Methyltransferase Inhibitors" by people in this website by year, and whether "Catechol O-Methyltransferase Inhibitors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 1 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Catechol O-Methyltransferase Inhibitors" by people in Profiles.
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A systematic review of the cognitive effects of the COMT inhibitor, tolcapone, in adult humans. CNS Spectr. 2024 Jun; 29(3):166-175.
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Cortical dopamine reduces the impact of motivational biases governing automated behaviour. Neuropsychopharmacology. 2022 07; 47(8):1503-1512.
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Towards non-surgical therapy for uterine fibroids: catechol-O-methyl transferase inhibitor shrinks uterine fibroid lesions in the Eker rat model. Hum Reprod. 2011 Nov; 26(11):3008-18.
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Kleptomania treated with tolcapone, a catechol-O-methyl-transferase (COMT) inhibitor. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jan 15; 35(1):295-6.
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Treatment with an inhibitor of catechol-O-methyltransferase activity reduces preterm birth and impedes cervical resistance to stretch in pregnant rats. Reproduction. 2007 Dec; 134(6):831-9.
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Regulation of catechol O-methyltransferase expression in granulosa cells: a potential role for follicular arrest in polycystic ovary syndrome. Fertil Steril. 2008 May; 89(5 Suppl):1414-21.
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Catechol-O-methyltransferase polymorphism is associated with increased uterine leiomyoma risk in different ethnic groups. J Soc Gynecol Investig. 2006 Feb; 13(2):136-44.
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Catechol-O-methyltransferase inhibitors in Parkinson's disease. Lancet. 1998 Jun 27; 351(9120):1966.