"Axon Initial Segment" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
First segment of axon that connects distal axon segments to the neuronal CELL BODY at the axon hillock region. The axon initial segment is not protected by the MYELIN SHEATH and has properties critical for axonal growth. The axon initial segment and the axon hillock form an axonal trigger zone.
Below are MeSH descriptors whose meaning is more general than "Axon Initial Segment".
Below are MeSH descriptors whose meaning is more specific than "Axon Initial Segment".
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Below are the most recent publications written about "Axon Initial Segment" by people in Profiles.
SUMOylation of NaV1.2 channels regulates the velocity of backpropagating action potentials in cortical pyramidal neurons. Elife. 2023 02 16; 12.
Endocytosis in the axon initial segment maintains neuronal polarity. Nature. 2022 09; 609(7925):128-135.