"CD48 Antigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 40-45 KDa GPI-linked protein in the SLAM family that consists of two IMMUNOGLOBULIN C2-SET DOMAINS. It is expressed on the surface of a variety of cells with immune functions, including THYMOCYTES; mature B-LYMPHOCYTES and T-LYMPHOCYTES; NATURAL KILLER CELLS; DENDRITIC CELLS; MAST CELLS; and EOSINOPHILS. It binds to CD2 and 2B4 (CD244) receptors to activate and modulate the immunologic response.
- CD48 Antigen
- Antigen, CD48
- Signaling Lymphocytic Activation Molecule 2
- Blast1 Antigen
- B-Lymphocyte Activation Marker BLAST-1
- B Lymphocyte Activation Marker BLAST 1
- Leukocyte Antigen MEM-102
- Leukocyte Antigen MEM 102
- MEM-102, Leukocyte Antigen
- Signal-Transducing Glycoprotein-60
- Glycoprotein-60, Signal-Transducing
- Signal Transducing Glycoprotein 60
- P41 Antigen
- Antigen, P41
- SLAM Family Member 2
- SLAMF2 Protein
- BCM1 Surface Antigen
- Surface Antigen, BCM1
- Signaling Lymphocytic Activation Molecule Family Member 2
- MRC OX-45 Antigen
- Antigen, MRC OX-45
- MRC OX 45 Antigen
Below are MeSH descriptors whose meaning is more general than "CD48 Antigen".
Below are MeSH descriptors whose meaning is more specific than "CD48 Antigen".
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Below are the most recent publications written about "CD48 Antigen" by people in Profiles.
Engagement of NK receptor NKG2D, but not 2B4, results in self-reactive CD8+ T cells and autoimmune vitiligo. Autoimmunity. 2011 Dec; 44(8):599-606.
Molecular basis of the dual functions of 2B4 (CD244). J Immunol. 2008 Jun 15; 180(12):8159-67.
2B4 inhibits NK-cell fratricide. Blood. 2007 Sep 15; 110(6):2020-3.
Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions. Blood. 2006 Apr 15; 107(8):3181-8.
2B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice. Blood. 2005 Aug 15; 106(4):1337-40.
Targeted disruption of the 2B4 gene in mice reveals an in vivo role of 2B4 (CD244) in the rejection of B16 melanoma cells. J Immunol. 2005 Jan 15; 174(2):800-7.
2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells. J Exp Med. 2004 May 03; 199(9):1245-54.
Cutting edge: the NK cell receptor 2B4 augments antigen-specific T cell cytotoxicity through CD48 ligation on neighboring T cells. J Immunol. 2003 May 15; 170(10):4881-5.
Blast-1 possesses a glycosyl-phosphatidylinositol (GPI) membrane anchor, is related to LFA-3 and OX-45, and maps to chromosome 1q21-23. J Exp Med. 1989 Mar 01; 169(3):1087-99.