"CD48 Antigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 40-45 KDa GPI-linked protein in the SLAM family that consists of two IMMUNOGLOBULIN C2-SET DOMAINS. It is expressed on the surface of a variety of cells with immune functions, including THYMOCYTES; mature B-LYMPHOCYTES and T-LYMPHOCYTES; NATURAL KILLER CELLS; DENDRITIC CELLS; MAST CELLS; and EOSINOPHILS. It binds to CD2 and 2B4 (CD244) receptors to activate and modulate the immunologic response.
| Descriptor ID |
D000071178
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| MeSH Number(s) |
D12.776.395.550.448.180 D12.776.395.550.736.250 D12.776.543.484.500.180 D12.776.543.550.418.180 D12.776.543.550.746.250 D12.776.543.750.705.970.250
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| Concept/Terms |
CD48 Antigen- CD48 Antigen
- Antigen, CD48
- Signaling Lymphocytic Activation Molecule 2
- Blast1 Antigen
- B-Lymphocyte Activation Marker BLAST-1
- B Lymphocyte Activation Marker BLAST 1
- Leukocyte Antigen MEM-102
- Leukocyte Antigen MEM 102
- MEM-102, Leukocyte Antigen
- Signal-Transducing Glycoprotein-60
- Glycoprotein-60, Signal-Transducing
- Signal Transducing Glycoprotein 60
- P41 Antigen
- Antigen, P41
- SLAM Family Member 2
- SLAMF2 Protein
- BCM1 Surface Antigen
- Surface Antigen, BCM1
- Signaling Lymphocytic Activation Molecule Family Member 2
- MRC OX-45 Antigen
- Antigen, MRC OX-45
- MRC OX 45 Antigen
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Below are MeSH descriptors whose meaning is more general than "CD48 Antigen".
Below are MeSH descriptors whose meaning is more specific than "CD48 Antigen".
This graph shows the total number of publications written about "CD48 Antigen" by people in this website by year, and whether "CD48 Antigen" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 3 | 3 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "CD48 Antigen" by people in Profiles.
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Engagement of NK receptor NKG2D, but not 2B4, results in self-reactive CD8+ T cells and autoimmune vitiligo. Autoimmunity. 2011 Dec; 44(8):599-606.
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Molecular basis of the dual functions of 2B4 (CD244). J Immunol. 2008 Jun 15; 180(12):8159-67.
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2B4 inhibits NK-cell fratricide. Blood. 2007 Sep 15; 110(6):2020-3.
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Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions. Blood. 2006 Apr 15; 107(8):3181-8.
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2B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice. Blood. 2005 Aug 15; 106(4):1337-40.
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Targeted disruption of the 2B4 gene in mice reveals an in vivo role of 2B4 (CD244) in the rejection of B16 melanoma cells. J Immunol. 2005 Jan 15; 174(2):800-7.
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2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells. J Exp Med. 2004 May 03; 199(9):1245-54.
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Cutting edge: the NK cell receptor 2B4 augments antigen-specific T cell cytotoxicity through CD48 ligation on neighboring T cells. J Immunol. 2003 May 15; 170(10):4881-5.
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Blast-1 possesses a glycosyl-phosphatidylinositol (GPI) membrane anchor, is related to LFA-3 and OX-45, and maps to chromosome 1q21-23. J Exp Med. 1989 Mar 01; 169(3):1087-99.