"NEDD8 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitin-like protein that functions in CELL CYCLE regulation and embryogenesis. It is attached covalently to its substrates following activation by the UBIQUITIN-ACTIVATING ENZYME E1-UBA3 enzyme complex. NEDD8 attaches to CULLINS, activating their E3 UBIQUITIN LIGASE activity, to promote polyubiquitination and degradation of CYCLINS and regulatory proteins
- NEDD8 Protein
- Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8
- Neural Precursor Cell Expressed Developmentally Down Regulated Protein 8
- NEDD-8 Protein
- NEDD 8 Protein
- Ubiquitin-like Protein NEDD8
- NEDD8, Ubiquitin-like Protein
- Ubiquitin like Protein NEDD8
Below are MeSH descriptors whose meaning is more general than "NEDD8 Protein".
Below are MeSH descriptors whose meaning is more specific than "NEDD8 Protein".
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Below are the most recent publications written about "NEDD8 Protein" by people in Profiles.
Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma. Clin Cancer Res. 2016 Jan 01; 22(1):34-43.
Inhibition of CUL4A Neddylation causes a reversible block to SAMHD1-mediated restriction of HIV-1. J Virol. 2013 Nov; 87(21):11741-50.