"Protein Kinase C beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
PKC beta encodes two proteins (PKCB1 and PKCBII) generated by alternative splicing of C-terminal exons. It is widely distributed with wide-ranging roles in processes such as B-cell receptor regulation, oxidative stress-induced apoptosis, androgen receptor-dependent transcriptional regulation, insulin signaling, and endothelial cell proliferation.
| Descriptor ID |
D064546
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.725.049
|
| Concept/Terms |
Protein Kinase C beta2- Protein Kinase C beta2
- PKCbeta2
- Protein Kinase C-beta(II)
- PKCBII
- PKC-beta II
- PKC beta II
- Protein Kinase C beta I
- Protein Kinase C-beta (II)
- PKC beta 2
- beta 2, PKC
- Protein Kinase C beta II
|
Below are MeSH descriptors whose meaning is more general than "Protein Kinase C beta".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C beta".
This graph shows the total number of publications written about "Protein Kinase C beta" by people in this website by year, and whether "Protein Kinase C beta" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Kinase C beta" by people in Profiles.
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All-trans retinoic acid and protein kinase C a/ß1 inhibitor combined treatment targets cancer stem cells and impairs breast tumor progression. Sci Rep. 2021 03 15; 11(1):6044.
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Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKCa subversion induces up-regulation of PKCßII expression in B lymphocytes. Haematologica. 2015 Apr; 100(4):499-510.
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Protein kinase C-ß contributes to impaired endothelial insulin signaling in humans with diabetes mellitus. Circulation. 2013 Jan 01; 127(1):86-95.
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Conventional protein kinase C-a (PKC-a) and PKC-ß negatively regulate RIG-I antiviral signal transduction. J Virol. 2012 Feb; 86(3):1358-71.
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A Gynecologic Oncology Group phase II trial of the protein kinase C-beta inhibitor, enzastaurin and evaluation of markers with potential predictive and prognostic value in persistent or recurrent epithelial ovarian and primary peritoneal malignancies. Gynecol Oncol. 2011 Jun 01; 121(3):455-61.
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Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications. Rev Endocr Metab Disord. 2010 Mar; 11(1):61-74.
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Activation of protein kinase C{eta} by type I interferons. J Biol Chem. 2009 Apr 17; 284(16):10301-14.
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Protein kinase C beta in malignant pleural mesothelioma. Anticancer Drugs. 2008 Oct; 19(9):841-8.
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Protein kinase C-beta inhibition: a promise not yet fulfilled. Clin J Am Soc Nephrol. 2007 Jul; 2(4):619-20.
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Effect of ruboxistaurin on urinary transforming growth factor-beta in patients with diabetic nephropathy and type 2 diabetes. Diabetes Care. 2007 Apr; 30(4):995-6.