 Complement Pathway, Alternative
"Complement Pathway, Alternative" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Complement activation initiated by the interaction of microbial ANTIGENS with COMPLEMENT C3B. When COMPLEMENT FACTOR B binds to the membrane-bound C3b, COMPLEMENT FACTOR D cleaves it to form alternative C3 CONVERTASE (C3BBB) which, stabilized by COMPLEMENT FACTOR P, is able to cleave multiple COMPLEMENT C3 to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
| Descriptor ID |
D003170
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| MeSH Number(s) |
G12.425.255.695
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| Concept/Terms |
Complement Pathway, Alternative- Complement Pathway, Alternative
- Alternative Complement Activation Pathway
- Complement Activation Pathway, Alternative
- Alternative Complement Pathway
- Properdin Pathway
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Below are MeSH descriptors whose meaning is more general than "Complement Pathway, Alternative".
Below are MeSH descriptors whose meaning is more specific than "Complement Pathway, Alternative".
This graph shows the total number of publications written about "Complement Pathway, Alternative" by people in this website by year, and whether "Complement Pathway, Alternative" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1989 | 1 | 0 | 1 | | 1999 | 0 | 1 | 1 | | 2007 | 1 | 1 | 2 | | 2010 | 0 | 1 | 1 | | 2012 | 1 | 0 | 1 | | 2020 | 0 | 2 | 2 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement Pathway, Alternative" by people in Profiles.
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Mahajan S, Jacob A, Kelkar A, Chang A, Mcskimming D, Neelamegham S, Quigg RJ, Alexander JJ. Local complement factor H protects kidney endothelial cell structure and function. Kidney Int. 2021 10; 100(4):824-836.
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Zhang Y, Kremsdorf RA, Sperati CJ, Henriksen KJ, Mori M, Goodfellow RX, Pitcher GR, Benson CL, Borsa NG, Taylor RP, Nester CM, Smith RJH. Mutation of complement factor B causing massive fluid-phase dysregulation of the alternative complement pathway can result in atypical hemolytic uremic syndrome. Kidney Int. 2020 11; 98(5):1265-1274.
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Frid MG, McKeon BA, Thurman JM, Maron BA, Li M, Zhang H, Kumar S, Sullivan T, Laskowsky J, Fini MA, Hu S, Tuder RM, Gandjeva A, Wilkins MR, Rhodes CJ, Ghataorhe P, Leopold JA, Wang RS, Holers VM, Stenmark KR. Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension. Am J Respir Crit Care Med. 2020 01 15; 201(2):224-239.
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Thurman JM, Tchepeleva SN, Haas M, Panzer S, Boackle SA, Glogowska MJ, Quigg RJ, Holers VM. Complement alternative pathway activation in the autologous phase of nephrotoxic serum nephritis. Am J Physiol Renal Physiol. 2012 Jun 15; 302(12):F1529-36.
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Thomas SN, van der Vlies AJ, O'Neil CP, Reddy ST, Yu SS, Giorgio TD, Swartz MA, Hubbell JA. Engineering complement activation on polypropylene sulfide vaccine nanoparticles. Biomaterials. 2011 Mar; 32(8):2194-203.
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Smith RJ, Alexander J, Barlow PN, Botto M, Cassavant TL, Cook HT, de Córdoba SR, Hageman GS, Jokiranta TS, Kimberling WJ, Lambris JD, Lanning LD, Levidiotis V, Licht C, Lutz HU, Meri S, Pickering MC, Quigg RJ, Rops AL, Salant DJ, Sethi S, Thurman JM, Tully HF, Tully SP, van der Vlag J, Walker PD, Würzner R, Zipfel PF. New approaches to the treatment of dense deposit disease. J Am Soc Nephrol. 2007 Sep; 18(9):2447-56.
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Alexander JJ, Jacob A, Vezina P, Sekine H, Gilkeson GS, Quigg RJ. Absence of functional alternative complement pathway alleviates lupus cerebritis. Eur J Immunol. 2007 Jun; 37(6):1691-701.
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McQuillen DP, Gulati S, Ram S, Turner AK, Jani DB, Heeren TC, Rice PA. Complement processing and immunoglobulin binding to Neisseria gonorrhoeae determined in vitro simulates in vivo effects. J Infect Dis. 1999 Jan; 179(1):124-35.
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Clardy CW, Forristal J, Strife CF, West CD. A properdin dependent nephritic factor slowly activating C3, C5, and C9 in membranoproliferative glomerulonephritis, types I and III. Clin Immunol Immunopathol. 1989 Mar; 50(3):333-47.
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