Complement Pathway, Alternative
"Complement Pathway, Alternative" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Complement activation initiated by the interaction of microbial ANTIGENS with COMPLEMENT C3B. When COMPLEMENT FACTOR B binds to the membrane-bound C3b, COMPLEMENT FACTOR D cleaves it to form alternative C3 CONVERTASE (C3BBB) which, stabilized by COMPLEMENT FACTOR P, is able to cleave multiple COMPLEMENT C3 to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
| Descriptor ID |
D003170
|
| MeSH Number(s) |
G12.274.695
|
| Concept/Terms |
Complement Pathway, Alternative- Complement Pathway, Alternative
- Alternative Complement Pathway
- Alternative Complement Activation Pathway
- Properdin Pathway
- Complement Activation Pathway, Alternative
|
Below are MeSH descriptors whose meaning is more general than "Complement Pathway, Alternative".
Below are MeSH descriptors whose meaning is more specific than "Complement Pathway, Alternative".
This graph shows the total number of publications written about "Complement Pathway, Alternative" by people in this website by year, and whether "Complement Pathway, Alternative" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 1 | 2 |
| 2007 | 1 | 1 | 2 |
| 2010 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2020 | 0 | 2 | 2 |
| 2021 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Complement Pathway, Alternative" by people in Profiles.
-
Local complement factor H protects kidney endothelial cell structure and function. Kidney Int. 2021 10; 100(4):824-836.
-
Mutation of complement factor B causing massive fluid-phase dysregulation of the alternative complement pathway can result in atypical hemolytic uremic syndrome. Kidney Int. 2020 11; 98(5):1265-1274.
-
Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension. Am J Respir Crit Care Med. 2020 01 15; 201(2):224-239.
-
Complement alternative pathway activation in the autologous phase of nephrotoxic serum nephritis. Am J Physiol Renal Physiol. 2012 Jun 15; 302(12):F1529-36.
-
Engineering complement activation on polypropylene sulfide vaccine nanoparticles. Biomaterials. 2011 Mar; 32(8):2194-203.
-
New approaches to the treatment of dense deposit disease. J Am Soc Nephrol. 2007 Sep; 18(9):2447-56.
-
Absence of functional alternative complement pathway alleviates lupus cerebritis. Eur J Immunol. 2007 Jun; 37(6):1691-701.
-
The anti-factor D antibody, MAb 166-32, inhibits the alternative pathway of the human complement system. Transplant Proc. 1999 Aug; 31(5):2168-71.
-
Complement processing and immunoglobulin binding to Neisseria gonorrhoeae determined in vitro simulates in vivo effects. J Infect Dis. 1999 Jan; 179(1):124-35.
-
A properdin dependent nephritic factor slowly activating C3, C5, and C9 in membranoproliferative glomerulonephritis, types I and III. Clin Immunol Immunopathol. 1989 Mar; 50(3):333-47.