 Lysine
"Lysine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An essential amino acid. It is often added to animal feed.
| Descriptor ID |
D008239
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| MeSH Number(s) |
D12.125.068.555 D12.125.095.647 D12.125.142.497
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Lysine".
Below are MeSH descriptors whose meaning is more specific than "Lysine".
This graph shows the total number of publications written about "Lysine" by people in this website by year, and whether "Lysine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1984 | 0 | 1 | 1 | | 1987 | 2 | 0 | 2 | | 1989 | 0 | 2 | 2 | | 1991 | 0 | 1 | 1 | | 1992 | 0 | 1 | 1 | | 1995 | 0 | 3 | 3 | | 1996 | 1 | 1 | 2 | | 1997 | 0 | 2 | 2 | | 2000 | 0 | 1 | 1 | | 2001 | 0 | 3 | 3 | | 2002 | 1 | 2 | 3 | | 2003 | 1 | 0 | 1 | | 2004 | 1 | 2 | 3 | | 2005 | 3 | 4 | 7 | | 2006 | 1 | 1 | 2 | | 2007 | 2 | 2 | 4 | | 2008 | 1 | 0 | 1 | | 2009 | 0 | 3 | 3 | | 2010 | 5 | 3 | 8 | | 2011 | 3 | 6 | 9 | | 2012 | 2 | 3 | 5 | | 2013 | 4 | 3 | 7 | | 2014 | 5 | 6 | 11 | | 2015 | 5 | 3 | 8 | | 2016 | 1 | 6 | 7 | | 2017 | 2 | 3 | 5 | | 2018 | 2 | 1 | 3 | | 2019 | 2 | 2 | 4 | | 2020 | 2 | 3 | 5 | | 2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "Lysine" by people in Profiles.
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Pan M, Zheng Q, Wang T, Liang L, Mao J, Zuo C, Ding R, Ai H, Xie Y, Si D, Yu Y, Liu L, Zhao M. Structural insights into Ubr1-mediated N-degron polyubiquitination. Nature. 2021 12; 600(7888):334-338.
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Chen D, Xia S, Zhang R, Li Y, Famulare CA, Fan H, Wu R, Wang M, Zhu AC, Elf SE, Su R, Dong L, Arellano M, Blum WG, Mao H, Lonial S, Stock W, Odenike O, Le Beau M, Boggon TJ, He C, Chen J, Gao X, Levine RL, Chen J. Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells. Mol Cell. 2021 09 16; 81(18):3833-3847.e11.
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Gobert AP, Finley JL, Latour YL, Asim M, Smith TM, Verriere TG, Barry DP, Allaman MM, Delagado AG, Rose KL, Calcutt MW, Schey KL, Sierra JC, Piazuelo MB, Mirmira RG, Wilson KT. Hypusination Orchestrates the Antimicrobial Response of Macrophages. Cell Rep. 2020 12 15; 33(11):108510.
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Vougiouklakis T, Bernard BJ, Nigam N, Burkitt K, Nakamura Y, Saloura V. Clinicopathologic significance of protein lysine methyltransferases in cancer. Clin Epigenetics. 2020 10 13; 12(1):146.
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Wu L, Crawley CD, Garofalo A, Nichols JW, Campbell PA, Khramtsova GF, Olopade OI, Weichselbaum RR, Yamini B. p50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability. Nat Commun. 2020 10 06; 11(1):5007.
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Douillet D, Sze CC, Ryan C, Piunti A, Shah AP, Ugarenko M, Marshall SA, Rendleman EJ, Zha D, Helmin KA, Zhao Z, Cao K, Morgan MA, Singer BD, Bartom ET, Smith ER, Shilatifard A. Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation. Nat Genet. 2020 06; 52(6):615-625.
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Mastracci TL, Colvin SC, Padgett LR, Mirmira RG. Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes. PLoS One. 2020; 15(3):e0230627.
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Levasseur EM, Yamada K, Piñeros AR, Wu W, Syed F, Orr KS, Anderson-Baucum E, Mastracci TL, Maier B, Mosley AL, Liu Y, Bernal-Mizrachi E, Alonso LC, Scott D, Garcia-Ocaña A, Tersey SA, Mirmira RG. Hypusine biosynthesis in ß cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis. Sci Signal. 2019 12 03; 12(610).
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Zhang D, Tang Z, Huang H, Zhou G, Cui C, Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, Ding J, Czyz D, Hu R, Ye Z, He M, Zheng YG, Shuman HA, Dai L, Ren B, Roeder RG, Becker L, Zhao Y. Metabolic regulation of gene expression by histone lactylation. Nature. 2019 10; 574(7779):575-580.
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Koncar RF, Dey BR, Stanton AJ, Agrawal N, Wassell ML, McCarl LH, Locke AL, Sanders L, Morozova-Vaske O, Myers MI, Hamilton RL, Carcaboso AM, Kohanbash G, Hu B, Amankulor NM, Felker J, Kambhampati M, Nazarian J, Becher OJ, James CD, Hashizume R, Broniscer A, Pollack IF, Agnihotri S. Identification of Novel RAS Signaling Therapeutic Vulnerabilities in Diffuse Intrinsic Pontine Gliomas. Cancer Res. 2019 08 15; 79(16):4026-4041.
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