"Asparagine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
| Descriptor ID |
D001216
|
| MeSH Number(s) |
D12.125.068.060 D12.125.095.165 D12.125.154.049
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Asparagine".
Below are MeSH descriptors whose meaning is more specific than "Asparagine".
This graph shows the total number of publications written about "Asparagine" by people in this website by year, and whether "Asparagine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2004 | 1 | 1 | 2 |
| 2005 | 0 | 2 | 2 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 3 | 4 |
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Asparagine" by people in Profiles.
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Important Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels. Biophys J. 2015 Dec 01; 109(11):2277-86.
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In vivo evaluation of poly-l-asparagine nanocapsules as carriers for anti-cancer drug delivery. Int J Pharm. 2013 Dec 15; 458(1):83-9.
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Restricted N-glycan conformational space in the PDB and its implication in glycan structure modeling. PLoS Comput Biol. 2013; 9(3):e1002946.
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Role of a salt bridge in the model protein crambin explored by chemical protein synthesis: X-ray structure of a unique protein analogue, [V15A]crambin-alpha-carboxamide. Mol Biosyst. 2009 Jul; 5(7):750-6.
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Molecular driving forces determining potassium channel slow inactivation. Nat Struct Mol Biol. 2007 Nov; 14(11):1062-9.
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Serial perturbation of MinK in IKs implies an alpha-helical transmembrane span traversing the channel corpus. Biophys J. 2007 Oct 01; 93(7):2332-40.
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A novel FKRP mutation in congenital muscular dystrophy disrupts the dystrophin glycoprotein complex. Neuromuscul Disord. 2007 Apr; 17(4):285-9.
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Effective asparagine depletion with pegylated asparaginase results in improved outcomes in adult acute lymphoblastic leukemia: Cancer and Leukemia Group B Study 9511. Blood. 2007 May 15; 109(10):4164-7.
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An inner pore residue (Asn406) in the Nav1.5 channel controls slow inactivation and enhances mibefradil block to T-type Ca2+ channel levels. Mol Pharmacol. 2006 Nov; 70(5):1514-23.
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Optimization of a self antigen for presentation of multiple epitopes in cancer immunity. J Clin Invest. 2006 May; 116(5):1382-90.