"Plicamycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.
- Aureolic Acid
- Acid, Aureolic
Below are MeSH descriptors whose meaning is more general than "Plicamycin".
Below are MeSH descriptors whose meaning is more specific than "Plicamycin".
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Below are the most recent publications written about "Plicamycin" by people in Profiles.
Mithramycin suppresses DNA damage repair via targeting androgen receptor in prostate cancer. Cancer Lett. 2020 09 28; 488:40-49.
Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma. Cell Rep. 2017 01 24; 18(4):961-976.
EPS8 inhibition increases cisplatin sensitivity in lung cancer cells. PLoS One. 2013; 8(12):e82220.
The transcription factor Sp3 regulates the expression of a metastasis-related marker of sarcoma, actin filament-associated protein 1-like 1 (AFAP1L1). PLoS One. 2013; 8(1):e49709.
Characterization of the basal promoter element of the human type 5 17beta-hydroxysteroid dehydrogenase gene. Biochim Biophys Acta. 2005 May 01; 1728(3):115-25.
Treatment of cancer-associated hypercalcemia with mithramycin and oral etidronate disodium. Clin Pharm. 1985 Mar-Apr; 4(2):204-5.
Case report: clinical pathological correlations in a case of primary parathyroid carcinoma. Ann Clin Lab Sci. 1984 Nov-Dec; 14(6):458-63.