"Plicamycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.
| Descriptor ID |
D008926
|
| MeSH Number(s) |
D02.455.426.559.847.562.050.650 D04.615.562.050.650 D09.408.051.059.650
|
| Concept/Terms |
Plicamycin- Plicamycin
- Mitramycin
- Aureolic Acid
- Acid, Aureolic
- Mithramycin
|
Below are MeSH descriptors whose meaning is more general than "Plicamycin".
Below are MeSH descriptors whose meaning is more specific than "Plicamycin".
This graph shows the total number of publications written about "Plicamycin" by people in this website by year, and whether "Plicamycin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2013 | 0 | 2 | 2 |
| 2017 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Plicamycin" by people in Profiles.
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Mithramycin suppresses DNA damage repair via targeting androgen receptor in prostate cancer. Cancer Lett. 2020 09 28; 488:40-49.
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Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma. Cell Rep. 2017 01 24; 18(4):961-976.
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EPS8 inhibition increases cisplatin sensitivity in lung cancer cells. PLoS One. 2013; 8(12):e82220.
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The transcription factor Sp3 regulates the expression of a metastasis-related marker of sarcoma, actin filament-associated protein 1-like 1 (AFAP1L1). PLoS One. 2013; 8(1):e49709.
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Characterization of the basal promoter element of the human type 5 17beta-hydroxysteroid dehydrogenase gene. Biochim Biophys Acta. 2005 May 01; 1728(3):115-25.
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Treatment of cancer-associated hypercalcemia with mithramycin and oral etidronate disodium. Clin Pharm. 1985 Mar-Apr; 4(2):204-5.
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Case report: clinical pathological correlations in a case of primary parathyroid carcinoma. Ann Clin Lab Sci. 1984 Nov-Dec; 14(6):458-63.