 Propylthiouracil
"Propylthiouracil" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)
| Descriptor ID |
D011441
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| MeSH Number(s) |
D03.383.742.698.875.842.708
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Propylthiouracil".
Below are MeSH descriptors whose meaning is more specific than "Propylthiouracil".
This graph shows the total number of publications written about "Propylthiouracil" by people in this website by year, and whether "Propylthiouracil" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1982 | 1 | 0 | 1 | | 1989 | 1 | 0 | 1 | | 2001 | 0 | 2 | 2 | | 2003 | 0 | 2 | 2 | | 2008 | 0 | 2 | 2 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Propylthiouracil" by people in Profiles.
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Refetoff S, Pappa T, Williams MK, Matheus MG, Liao XH, Hansen K, Nicol L, Pierce M, Blasco PA, Wiebers Jensen M, Bernal J, Weiss RE, Dumitrescu AM, LaFranchi S. Prenatal Treatment of Thyroid Hormone Cell Membrane Transport Defect Caused by MCT8 Gene Mutation. Thyroid. 2021 05; 31(5):713-720.
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Bayraktaroglu T, Noel J, Alagol F, Colak N, Mukaddes NM, Refetoff S. Thyroid hormone receptor beta gene mutation (P453A) in a family producing resistance to thyroid hormone. Exp Clin Endocrinol Diabetes. 2009 Jan; 117(1):34-7.
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Pillai JB, Chen M, Rajamohan SB, Samant S, Pillai VB, Gupta M, Gupta MP. Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the alpha-myosin heavy chain expression. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1388-97.
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Ortiga-Carvalho TM, Hashimoto K, Pazos-Moura CC, Geenen D, Cohen R, Lang RM, Wondisford FE. Thyroid hormone resistance in the heart: role of the thyroid hormone receptor beta isoform. Endocrinology. 2004 Apr; 145(4):1625-33.
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Yen PM, Feng X, Flamant F, Chen Y, Walker RL, Weiss RE, Chassande O, Samarut J, Refetoff S, Meltzer PS. Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice. EMBO Rep. 2003 Jun; 4(6):581-7.
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Curcio C, Baqui MM, Salvatore D, Rihn BH, Mohr S, Harney JW, Larsen PR, Bianco AC. The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line. J Biol Chem. 2001 Aug 10; 276(32):30183-7.
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Macchia PE, Takeuchi Y, Kawai T, Cua K, Gauthier K, Chassande O, Seo H, Hayashi Y, Samarut J, Murata Y, Weiss RE, Refetoff S. Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor alpha. Proc Natl Acad Sci U S A. 2001 Jan 02; 98(1):349-54.
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Dias Júnior AA, Scalissi NM, Marone MM, Correa PH, Bianco AC. [Basedow-Graves' disease: analysis of various parameters in the prognosis of remission after clinical treatment]. Rev Paul Med. 1989 Mar-Apr; 107(2):69-74.
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Duck SC, Sty J. Technetium thyroid uptake ratios in pediatric Graves disease. J Pediatr. 1985 Dec; 107(6):905-9.
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Pacini F, Sridama V, Refetoff S. Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization. J Endocrinol Invest. 1982 Nov-Dec; 5(6):403-7.
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