 Pyruvate Carboxylase
"Pyruvate Carboxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biotin-dependent enzyme belonging to the ligase family that catalyzes the addition of CARBON DIOXIDE to pyruvate. It is occurs in both plants and animals. Deficiency of this enzyme causes severe psychomotor retardation and ACIDOSIS, LACTIC in infants. EC 6.4.1.1.
| Descriptor ID |
D011766
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| MeSH Number(s) |
D08.811.464.257.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Pyruvate Carboxylase".
Below are MeSH descriptors whose meaning is more specific than "Pyruvate Carboxylase".
This graph shows the total number of publications written about "Pyruvate Carboxylase" by people in this website by year, and whether "Pyruvate Carboxylase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1982 | 0 | 1 | 1 | | 1996 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Pyruvate Carboxylase" by people in Profiles.
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Schwörer S, Pavlova NN, Cimino FV, King B, Cai X, Sizemore GM, Thompson CB. Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment. Nat Metab. 2021 11; 3(11):1484-1499.
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Ogihara T, Chuang JC, Vestermark GL, Garmey JC, Ketchum RJ, Huang X, Brayman KL, Thorner MO, Repa JJ, Mirmira RG, Evans-Molina C. Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling. J Biol Chem. 2010 Feb 19; 285(8):5392-404.
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MacDonald MJ, Tang J, Polonsky KS. Low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of Zucker diabetic fatty rats. Diabetes. 1996 Nov; 45(11):1626-30.
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Tonsgard JH, Huttenlocher PR, Thisted RA. Lactic acidemia in Reye's syndrome. Pediatrics. 1982 Jan; 69(1):64-9.
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