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Peter Smith

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentPediatrics-Developmental and Behavioral
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Dr. Smith is a clinician, educator, advocate, and researcher. His areas of expertise include intellectual disability (including Down syndrome), autism, children with medical complexity, health care systems change, and ethics.

    Collapse Biography 
    Collapse education and training
    University of Notre Dame, IndianaBA05/1990Pre-professional & Theology
    University of Edinburgh, Scotland06/1991Theology
    Duke University, North CarolinaMD06/1995Medical School
    St. Louis Children's Hospital, Missouri06/1998Pediatrics
    Boston Children's Hospital/Harvard, Massachusetts06/2000Neurodevelopmental Disabilities
    Boston Children's Hospital/Harvard, Massachusetts06/2002Developmental-Behavioral Pediatrics
    Boston College, MassachusettsMA06/2002Theology-Ethics
    Collapse awards and honors
    1990Cavanaugh Award (Outstanding Undergraduate in the Department of Theology), University of Notre Dame
    1990 - 1991Rotary Foundation Ambassadorial Scholar, Rotary Foundation
    1999Von Meyer Fellowship Award, Harvard Medical School
    2000 - 2001NIMH Award Program in MH/DD, Harvard Medical School & Boston Children's Hospital
    2000 - 2002Dyson Advocacy Fellowship, Harvard Medical School & Boston Children’s Hospital
    2001 - 2002Chief Fellow, Division of General Pediatrics, Harvard Medical School & Boston Children’s Hospital
    2002Mel Levine Award for the Outstanding Fellow, Harvard Medical School & Boston Children's Hospital
    2002Distinguished Service Award, The ARC of Eastern Middlesex, Reading, MA
    2002Elected Fellow, American Association on Intellectual and Developmental Disabilities
    2016Outstanding Teacher Award, Feinberg School of Medicine, Northwestern University

    Collapse Research 
    Collapse research activities and funding
         (Peter J. Smith, MD, MA)Nov 1, 2018 - Oct 31, 2021
    The Oberweiler Foundation
    Keith Veselik, M.D. Medical Education Program at Almost Home Kids
    Role Description: The goal of this project is to continue and expand the training program for medical students, residents, and fellows regarding the care of children with medical complexity.
    Role: Co-PI
         (Peter J. Smith, MD, MA)Sep 1, 2018 - Sep 1, 2018
    Coleman Foundation
    Training Program in Developmental & Behavioral Pediatrics (DBP) for Advance Practice Registered Nurses (APRN’s) at Almost Home Kids
    Role Description: The goal of this project is to create a training program in DBP for APRN's.
    Role: Co-PI
    T73 MC11047     (Kruti Acharya, MD)Sep 1, 2016 - Aug 31, 2021
    HRSA
    Illinois Leadership for Children with Neurodevelopmental and Related Disabilities (IL LEND)
    Role Description: This goal of this training grant is to continue to foster an interdisciplinary workforce of leaders in the service of individuals with neurodevelopmental disabilities, including autism, and intellectual disabilities.
    Role: Ethic Consultant
    S10RR028860     (SMITH, PETER JS)May 6, 2010 - May 5, 2011
    NIH
    Live cell, high speed and resolution, spectral confocal microscope
    Role: Principal Investigator
    R41DK065351     (SMITH, PETER JS)Sep 15, 2003 - Sep 14, 2005
    NIH
    Ultra-micro oxygen sensor development
    Role: Principal Investigator
    R21DK063984     (SMITH, PETER JS)Apr 1, 2003 - Mar 31, 2006
    NIH
    Role of islet structure and function
    Role: Principal Investigator
    P41RR001395     (SMITH, PETER JS)Sep 1, 1982 - Sep 16, 2011
    NIH
    BioCurrents Research Center
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Abulimiti A, Bae H, Ali A, Balakrishnan S, Tsujishita M, Gveric D, Tierney TS, Jonas EA, Smith PJS, Gentleman SM, Alavian KN. Reduced DJ-1-F1Fo ATP synthase association correlates with midbrain dopaminergic neuron vulnerability in idiopathic Parkinson's disease. Sci Adv. 2025 Jun 06; 11(23):eads3051. PMID: 40479058; PMCID: PMC12143374.
      Citations: 1     Fields:    Translation:HumansCells
    2. MacColl Garfinkel A, Mnatsakanyan N, Patel JH, Wills AE, Shteyman A, Smith PJS, Alavian KN, Jonas EA, Khokha MK. Mitochondrial leak metabolism induces the Spemann-Mangold Organizer via Hif-1a in Xenopus. Dev Cell. 2023 11 20; 58(22):2597-2613.e4. PMID: 37673063; PMCID: PMC10840693.
      Citations: 6     Fields:    Translation:AnimalsCells
    3. Carbone PS, Smith PJ, Lewis C, LeBlanc C. Promoting the Participation of Children and Adolescents With Disabilities in Sports, Recreation, and Physical Activity. Pediatrics. 2021 12 01; 148(6). PMID: 34851421.
      Citations: 32     Fields:    Translation:Humans
    4. Onishchenko D, Huang Y, van Horne J, Smith PJ, Msall ME, Chattopadhyay I. Reduced false positives in autism screening via digital biomarkers inferred from deep comorbidity patterns. Sci Adv. 2021 Oct 08; 7(41):eabf0354. PMID: 34613766; PMCID: PMC8494294.
      Citations: 12     Fields:    
    5. Malchow RP, Tchernookova BK, Choi JV, Smith PJS, Kramer RH, Kreitzer MA. Review and Hypothesis: A Potential Common Link Between Glial Cells, Calcium Changes, Modulation of Synaptic Transmission, Spreading Depression, Migraine, and Epilepsy-H. Front Cell Neurosci. 2021; 15:693095. PMID: 34539347; PMCID: PMC8446203.
      Citations: 5     
    6. Prabhakar PK, Wang HT, Smith PJ, Yang JY, Barnes WJ, Peña MJ, Moremen KW, Urbanowicz BR. Heterologous expression of plant glycosyltransferases for biochemistry and structural biology. Methods Cell Biol. 2020; 160:145-165. PMID: 32896313; PMCID: PMC7593805.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    7. Ruprecht C, Bartetzko MP, Senf D, Lakhina A, Smith PJ, Soto MJ, Oh H, Yang JY, Chapla D, Varon Silva D, Clausen MH, Hahn MG, Moremen KW, Urbanowicz BR, Pfrengle F. A Glycan Array-Based Assay for the Identification and Characterization of Plant Glycosyltransferases. Angew Chem Int Ed Engl. 2020 07 20; 59(30):12493-12498. PMID: 32396713; PMCID: PMC7383710.
      Citations: 20     Fields:    Translation:AnimalsCells
    8. Chen R, Park HA, Mnatsakanyan N, Niu Y, Licznerski P, Wu J, Miranda P, Graham M, Tang J, Boon AJW, Cossu G, Mandemakers W, Bonifati V, Smith PJS, Alavian KN, Jonas EA. Parkinson's disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth. Cell Death Dis. 2019 06 13; 10(6):469. PMID: 31197129; PMCID: PMC6565618.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    9. . Psychosocial Factors in Children and Youth With Special Health Care Needs and Their Families. Pediatrics. 2019; 1(143):e20183171.
    10. Glassgow AE, Martin MA, Caskey R, Bansa M, Gerges M, Johnson M, Marko M, Perry-Bell K, Risser HJ, Smith PJ, Van Voorhees B. An innovative health-care delivery model for children with medical complexity. J Child Health Care. 2017 Sep; 21(3):263-272. PMID: 29119824.
      Citations: 8     Fields:    Translation:Humans
    11. Adams M, Stringer T, de Kock C, Smith PJ, Land KM, Liu N, Tam C, Cheng LW, Njoroge M, Chibale K, Smith GS. Bioisosteric ferrocenyl-containing quinolines with antiplasmodial and antitrichomonal properties. Dalton Trans. 2016 Nov 29; 45(47):19086-19095. PMID: 27858010.
      Citations: 1     Fields:    Translation:AnimalsCells
    12. Tian W, Smith PJ, Msall M. Medically complex children and early intervention for comprehensive medical care at home. Pediatr Ann. 2015 Jan; 44(1):36-9. PMID: 25621626.
      Citations:    Fields:    Translation:Humans
    13. Alavian KN, Dworetzky SI, Bonanni L, Zhang P, Sacchetti S, Li H, Signore AP, Smith PJ, Gribkoff VK, Jonas EA. The mitochondrial complex V-associated large-conductance inner membrane current is regulated by cyclosporine and dexpramipexole. Mol Pharmacol. 2015 Jan; 87(1):1-8. PMID: 25332381; PMCID: PMC4279080.
      Citations: 21     Fields:    Translation:HumansCells
    14. Katis IN, Holloway JA, Madsen J, Faust SN, Garbis SD, Smith PJ, Voegeli D, Bader DL, Eason RW, Sones CL. Paper-based colorimetric enzyme linked immunosorbent assay fabricated by laser induced forward transfer. Biomicrofluidics. 2014 May; 8(3):036502. PMID: 24926392; PMCID: PMC4032417.
      Citations: 5     
    15. Brodsky AS, Fischer A, Miller DH, Vang S, MacLaughlan S, Wu HT, Yu J, Steinhoff M, Collins C, Smith PJ, Raphael BJ, Brard L. Expression profiling of primary and metastatic ovarian tumors reveals differences indicative of aggressive disease. PLoS One. 2014; 9(4):e94476. PMID: 24732363; PMCID: PMC3986100.
      Citations: 46     Fields:    Translation:Humans
    16. Van Mooy BA, Hmelo LR, Fredricks HF, Ossolinski JE, Pedler BE, Bogorff DJ, Smith PJ. Quantitative exploration of the contribution of settlement, growth, dispersal and grazing to the accumulation of natural marine biofilms on antifouling and fouling-release coatings. Biofouling. 2014 Feb; 30(2):223-36. PMID: 24417212; PMCID: PMC3935016.
      Citations:    Fields:    Translation:PHPublic Health
    17. Leeuwenburgh-Pronk WG, Smith PJ, van Vught AJ, Lantos JD, Tibboel D, de Hoog M, Buysse C. A baby with meningococcemia and septic shock. Pediatrics. 2012 Jul; 130(1):134-8. PMID: 22689868.
      Citations:    Fields:    Translation:Humans
    18. Heart E, Palo M, Womack T, Smith PJ, Gray JP. The level of menadione redox-cycling in pancreatic ß-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion. Toxicol Appl Pharmacol. 2012 Jan 15; 258(2):216-25. PMID: 22115979; PMCID: PMC3259196.
      Citations: 8     Fields:    Translation:AnimalsCells
    19. Smith PJ, Collis LP, Messerli MA. Windows to cell function and dysfunction: signatures written in the boundary layers. Bioessays. 2010 Jun; 32(6):514-23. PMID: 20486138.
      Citations: 3     Fields:    Translation:Cells
    20. Messerli MA, Smith PJ. Construction, theory, and practical considerations for using self-referencing of Ca(2+)-selective microelectrodes for monitoring extracellular Ca(2+) gradients. Methods Cell Biol. 2010; 99:91-111. PMID: 21035684.
      Citations: 5     Fields:    Translation:AnimalsCells
    21. Heart E, Cline GW, Collis LP, Pongratz RL, Gray JP, Smith PJ. Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab. 2009 Jun; 296(6):E1354-62. PMID: 19293334; PMCID: PMC2692397.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    22. Messerli MA, Collis LP, Smith PJ. Ion trapping with fast-response ion-selective microelectrodes enhances detection of extracellular ion channel gradients. Biophys J. 2009 Feb 18; 96(4):1597-605. PMID: 19217875; PMCID: PMC2717230.
      Citations: 4     Fields:    Translation:AnimalsCells
    23. Messerli MA, Kurtz I, Smith PJ. Characterization of optimized Na+ and Cl- liquid membranes for use with extracellular, self-referencing microelectrodes. Anal Bioanal Chem. 2008 Mar; 390(5):1355-9. PMID: 18193410.
      Citations: 7     Fields:    
    24. Heart E, Yaney GC, Corkey RF, Schultz V, Luc E, Liu L, Deeney JT, Shirihai O, Tornheim K, Smith PJ, Corkey BE. Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose. Biochem J. 2007 Apr 01; 403(1):197-205. PMID: 17181533; PMCID: PMC1828901.
      Citations: 27     Fields:    Translation:AnimalsCells
    25. Heart E, Smith PJ. Rhythm of the beta-cell oscillator is not governed by a single regulator: multiple systems contribute to oscillatory behavior. Am J Physiol Endocrinol Metab. 2007 May; 292(5):E1295-300. PMID: 17213468.
      Citations: 14     Fields:    Translation:AnimalsCells
    26. Smith PJS, Remsen D. Using Pharmabase to perform pharmacological analyses of cell function. Curr Protoc Bioinformatics. 2006 Mar; Chapter 14:14.2.1-14.2.17. PMID: 18428760.
      Citations: 1     Fields:    
    27. Messerli MA, Amaral-Zettler LA, Zettler E, Jung SK, Smith PJ, Sogin ML. Life at acidic pH imposes an increased energetic cost for a eukaryotic acidophile. J Exp Biol. 2005 Jul; 208(Pt 13):2569-79. PMID: 15961743.
      Citations: 17     Fields:    Translation:AnimalsCells
    28. Messerli MA, Smith PJ, Lewis RC, Robinson KR. Chloride fluxes in lily pollen tubes: a critical reevaluation. Plant J. 2004 Dec; 40(5):799-812. PMID: 15546362.
      Citations: 8     Fields:    Translation:Animals
    29. Hauser L, Adcock GJ, Smith PJ, Ramiréz JH, Carvalho GR. Loss of microsatellite diversity and low effective population size in an overexploited population of New Zealand snapper (Pagrus auratus). Proc Natl Acad Sci U S A. 2002 Sep 03; 99(18):11742-7. PMID: 12185245; PMCID: PMC129339.
      Citations: 98     Fields:    Translation:AnimalsCells
    30. Trimarchi JR, Liu L, Smith PJ, Keefe DL. Apoptosis recruits two-pore domain potassium channels used for homeostatic volume regulation. Am J Physiol Cell Physiol. 2002 Mar; 282(3):C588-94. PMID: 11832344.
      Citations: 17     Fields:    Translation:AnimalsCells
    31. Smith PJ, Mathews KS, Hehir T, Palfrey JS. . Educating Children With Disabilities: How Pediatricians Can Help. Contemporary Pediatrics 9:102-27. 2002; (9):102-27.
    32. Smith PJ, Crocker AC. Impact. Training Health Care Providers: Two Doctors Reflect on Values and Priorities. 2000; (13):6-7.
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