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Sebastian Pott

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Genetic Medicine
AddressChicago IL 60637
ORCID ORCID Icon0000-0002-4118-6150 Additional info
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    Collapse Overview 
    Collapse overview
    The ultimate research goal of my lab is to obtain a mechanistic and quantitative understanding of gene regulation in individual cells under normal conditions and in disease. Toward this aim, we are developing and applying single-cell and single-molecule genomics technologies that facilitate genome-wide measurements in primary tissues and cells.
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    Collapse Biography 
    Collapse education and training
    Princeton University, PrincetonPostdoc08/2014Genomics
    University of North Carolina, Chapel HillPostdoc07/2013Genomics
    Karolinska Institute, Stockholm, SwedenPhD06/2011Medical Sciences
    University of Hannover, Hanover, GermanyDiplom/Masters1/2006Biochemistry

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Carbonetto P, Luo K, Sarkar A, Hung A, Tayeb K, Pott S, Stephens M. GoM DE: interpreting structure in sequence count data with differential expression analysis allowing for grades of membership. Genome Biol. 2023 10 19; 24(1):236. PMID: 37858253; PMCID: PMC10588049.
      Citations:    Fields:    
    2. Fiebig A, Schnizlein MK, Pena-Rivera S, Trigodet F, Dubey AA, Hennessy M, Basu A, Pott S, Dalal S, Rubin D, Sogin ML, Murat Eren A, Chang EB, Crosson S. Bile acid fitness determinants of a Bacteroides fragilis isolate from a human pouchitis patient. bioRxiv. 2023 Oct 17. PMID: 37214927; PMCID: PMC10197588.
    3. Carbonetto P, Luo K, Sarkar A, Hung A, Tayeb K, Pott S, Stephens M. GoM DE: interpreting structure in sequence count data with differential expression analysis allowing for grades of membership. bioRxiv. 2023 Sep 14. PMID: 36945441; PMCID: PMC10028846.
    4. Selewa A, Luo K, Wasney M, Smith L, Sun X, Tang C, Eckart H, Moskowitz IP, Basu A, He X, Pott S. Single-cell genomics improves the discovery of risk variants and genes of atrial fibrillation. Nat Commun. 2023 08 17; 14(1):4999. PMID: 37591828; PMCID: PMC10435551.
      Citations: 1     Fields:    Translation:HumansCells
    5. Zilbauer M, James KR, Kaur M, Pott S, Li Z, Burger A, Thiagarajah JR, Burclaff J, Jahnsen FL, Perrone F, Ross AD, Matteoli G, Stakenborg N, Sujino T, Moor A, Bartolome-Casado R, Bækkevold ES, Zhou R, Xie B, Lau KS, Din S, Magness ST, Yao Q, Beyaz S, Arends M, Denadai-Souza A, Coburn LA, Gaublomme JT, Baldock R, Papatheodorou I, Ordovas-Montanes J, Boeckxstaens G, Hupalowska A, Teichmann SA, Regev A, Xavier RJ, Simmons A, Snyder MP, Wilson KT, Gut Cell Atlas Consortium, Human Cell Atlas Gut Biological Network Consortium. A Roadmap for the Human Gut Cell Atlas. Nat Rev Gastroenterol Hepatol. 2023 09; 20(9):597-614. PMID: 37258747; PMCID: PMC10527367.
      Citations: 2     Fields:    Translation:Humans
    6. Perrault EN, Shireman JM, Ali ES, Lin P, Preddy I, Park C, Budhiraja S, Baisiwala S, Dixit K, James CD, Heiland DH, Ben-Sahra I, Pott S, Basu A, Miska J, Ahmed AU. Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production. Sci Adv. 2023 05 19; 9(20):eade7236. PMID: 37196077; PMCID: PMC10191446.
      Citations: 1     Fields:    Translation:HumansCells
    7. Wasney M, Pott S. Simultaneous Measurement of DNA Methylation and Nucleosome Occupancy in Single Cells Using scNOMe-Seq. Methods Mol Biol. 2023; 2611:231-247. PMID: 36807071.
      Citations:    Fields:    Translation:Cells
    8. Rowton M, Perez-Cervantes C, Hur S, Jacobs-Li J, Lu E, Deng N, Guzzetta A, Hoffmann AD, Stocker M, Steimle JD, Lazarevic S, Oubaha S, Yang XH, Kim C, Yu S, Eckart H, Koska M, Hanson E, Chan SSK, Garry DJ, Kyba M, Basu A, Ikegami K, Pott S, Moskowitz IP. Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages. Dev Cell. 2022 09 26; 57(18):2181-2203.e9. PMID: 36108627; PMCID: PMC10506397.
      Citations:    Fields:    Translation:AnimalsCells
    9. Mittleman BE, Pott S, Warland S, Barr K, Cuevas C, Gilad Y. Divergence in alternative polyadenylation contributes to gene regulatory differences between humans and chimpanzees. Elife. 2021 02 17; 10. PMID: 33595436; PMCID: PMC7954529.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    10. Mittleman BE, Pott S, Warland S, Zeng T, Mu Z, Kaur M, Gilad Y, Li Y. Alternative polyadenylation mediates genetic regulation of gene expression. Elife. 2020 06 25; 9. PMID: 32584258; PMCID: PMC7338057.
      Citations: 24     Fields:    Translation:HumansCells
    11. Guzzetta A, Koska M, Rowton M, Sullivan KR, Jacobs-Li J, Kweon J, Hidalgo H, Eckart H, Hoffmann AD, Back R, Lozano S, Moon AM, Basu A, Bressan M, Pott S, Moskowitz IP. Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation. Proc Natl Acad Sci U S A. 2020 07 07; 117(27):15712-15723. PMID: 32561646; PMCID: PMC7354932.
      Citations: 14     Fields:    Translation:AnimalsCells
    12. Selewa A, Dohn R, Eckart H, Lozano S, Xie B, Gauchat E, Elorbany R, Rhodes K, Burnett J, Gilad Y, Pott S, Basu A. Systematic Comparison of High-throughput Single-Cell and Single-Nucleus Transcriptomes during Cardiomyocyte Differentiation. Sci Rep. 2020 01 30; 10(1):1535. PMID: 32001747; PMCID: PMC6992778.
      Citations: 38     Fields:    Translation:HumansCells
    13. Malik V, Zimmer D, Weng M, Holzner M, Arend M, Chen Y, Srivastava Y, Veerapandian V, Shah Z, Esteban MA, Wang H, Chen J, Hutchins AP, Pott S, Jauch R, Glaser LV, Velychko S, Schöler HR, Meijsing SH. Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2. Nat Commun. 2019 08 02; 10(1):3477. PMID: 31375664; PMCID: PMC6677745.
      Citations: 33     Fields:    Translation:AnimalsCells
    14. Chen CF, Pohl TJ, Pott S, Zakian VA. Two Pif1 Family DNA Helicases Cooperate in Centromere Replication and Segregation in Saccharomyces cerevisiae. Genetics. 2019 01; 211(1):105-119. PMID: 30442759; PMCID: PMC6325707.
      Citations: 13     Fields:    Translation:AnimalsCells
    15. Israel JW, Chappell GA, Simon JM, Pott S, Safi A, Lewis L, Cotney P, Boulos HS, Bodnar W, Lieb JD, Crawford GE, Furey TS, Rusyn I. Tissue- and strain-specific effects of a genotoxic carcinogen 1,3-butadiene on chromatin and transcription. Mamm Genome. 2018 02; 29(1-2):153-167. PMID: 29429127; PMCID: PMC6095468.
      Citations: 13     Fields:    Translation:AnimalsCells
    16. Chappell GA, Israel JW, Simon JM, Pott S, Safi A, Eklund K, Sexton KG, Bodnar W, Lieb JD, Crawford GE, Rusyn I, Furey TS. Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice. Environ Health Perspect. 2017 10 16; 125(10):107006. PMID: 29038090; PMCID: PMC5944832.
      Citations: 14     Fields:    Translation:AnimalsCells
    17. Pott S. Simultaneous measurement of chromatin accessibility, DNA methylation, and nucleosome phasing in single cells. Elife. 2017 06 27; 6. PMID: 28653622; PMCID: PMC5487215.
      Citations: 96     Fields:    Translation:HumansCells
    18. Tran PLT, Pohl TJ, Chen CF, Chan A, Pott S, Zakian VA. PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes. Nat Commun. 2017 04 21; 8:15025. PMID: 28429714; PMCID: PMC5413955.
      Citations: 62     Fields:    Translation:AnimalsCells
    19. Pott S, Lieb JD. Single-cell ATAC-seq: strength in numbers. Genome Biol. 2015 Aug 21; 16:172. PMID: 26294014; PMCID: PMC4546161.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    20. Pott S, Lieb JD. What are super-enhancers? Nat Genet. 2015 Jan; 47(1):8-12. PMID: 25547603.
      Citations: 352     Fields:    Translation:AnimalsCells
    21. Tropberger P, Pott S, Keller C, Kamieniarz-Gdula K, Caron M, Richter F, Li G, Mittler G, Liu ET, Margueron R, Schneider R, Bühler M. Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer. Cell. 2013 Feb 14; 152(4):859-72. PMID: 23415232.
      Citations: 117     Fields:    Translation:HumansAnimalsCells
    22. Pott S, Kamrani NK, Bourque G, Pettersson S, Liu ET. PPARG binding landscapes in macrophages suggest a genome-wide contribution of PU.1 to divergent PPARG binding in human and mouse. PLoS One. 2012; 7(10):e48102. PMID: 23118933; PMCID: PMC3485280.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    23. Nechanitzky R, Mandel E, Pott S, Liu E, Grosschedl R, Györy I, Boller S. Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells. Genes Dev. 2012 Apr 01; 26(7):668-82. PMID: 22431510; PMCID: PMC3323878.
      Citations: 77     Fields:    Translation:AnimalsCells
    24. Liu ET, Pott S, Huss M. Q&A: ChIP-seq technologies and the study of gene regulation. BMC Biol. 2010 May 14; 8:56. PMID: 20529237; PMCID: PMC2871264.
      Citations: 18     Fields:    Translation:Cells
    25. Treiber T, Mandel EM, Pott S, Firner S, Liu ET, Grosschedl R, Györy I. Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription- independent poising of chromatin. Immunity. 2010 May 28; 32(5):714-25. PMID: 20451411.
      Citations: 126     Fields:    Translation:AnimalsCells
    26. Hamza MS, Pott S, Vega VB, Thomsen JS, Kandhadayar GS, Ng PW, Chiu KP, Pettersson S, Wei CL, Ruan Y, Liu ET. De-novo identification of PPARgamma/RXR binding sites and direct targets during adipogenesis. PLoS One. 2009; 4(3):e4907. PMID: 19300518; PMCID: PMC2654672.
      Citations: 56     Fields:    Translation:AnimalsCells
    27. Lundin A, Bok CM, Aronsson L, Gustafsson JA, Pott S, Arulampalam V, Hibberd M, Rafter J, Pettersson S, Björkholm B. Gut flora, Toll-like receptors and nuclear receptors: a tripartite communication that tunes innate immunity in large intestine. Cell Microbiol. 2008 May; 10(5):1093-103. PMID: 18088401.
      Citations: 69     Fields:    Translation:AnimalsCells
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