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Sebastian Pott

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Genetic Medicine
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    The ultimate research goal of my lab is to obtain a mechanistic and quantitative understanding of gene regulation in individual cells under normal conditions and in disease. Toward this aim, we are developing and applying single-cell and single-molecule genomics technologies that facilitate genome-wide measurements in primary tissues and cells.


    Collapse Biography 
    Collapse education and training
    Princeton University, PrincetonPostdoc08/2014Genomics
    University of North Carolina, Chapel HillPostdoc07/2013Genomics
    Karolinska Institute, Stockholm, SwedenPhD06/2011Medical Sciences
    University of Hannover, Hanover, GermanyDiplom/Masters1/2006Biochemistry

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Rowton M, Perez-Cervantes C, Hur S, Jacobs-Li J, Lu E, Deng N, Guzzetta A, Hoffmann AD, Stocker M, Steimle JD, Lazarevic S, Oubaha S, Yang XH, Kim C, Yu S, Eckart H, Koska M, Hanson E, Chan SSK, Garry DJ, Kyba M, Basu A, Ikegami K, Pott S, Moskowitz IP. Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages. Dev Cell. 2022 09 26; 57(18):2181-2203.e9. PMID: 36108627.
      View in: PubMed
    2. Mittleman BE, Pott S, Warland S, Barr K, Cuevas C, Gilad Y. Divergence in alternative polyadenylation contributes to gene regulatory differences between humans and chimpanzees. Elife. 2021 02 17; 10. PMID: 33595436.
      View in: PubMed
    3. Mittleman BE, Pott S, Warland S, Zeng T, Mu Z, Kaur M, Gilad Y, Li Y. Alternative polyadenylation mediates genetic regulation of gene expression. Elife. 2020 06 25; 9. PMID: 32584258.
      View in: PubMed
    4. Guzzetta A, Koska M, Rowton M, Sullivan KR, Jacobs-Li J, Kweon J, Hidalgo H, Eckart H, Hoffmann AD, Back R, Lozano S, Moon AM, Basu A, Bressan M, Pott S, Moskowitz IP. Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation. Proc Natl Acad Sci U S A. 2020 07 07; 117(27):15712-15723. PMID: 32561646.
      View in: PubMed
    5. Selewa A, Dohn R, Eckart H, Lozano S, Xie B, Gauchat E, Elorbany R, Rhodes K, Burnett J, Gilad Y, Pott S, Basu A. Systematic Comparison of High-throughput Single-Cell and Single-Nucleus Transcriptomes during Cardiomyocyte Differentiation. Sci Rep. 2020 01 30; 10(1):1535. PMID: 32001747.
      View in: PubMed
    6. Malik V, Glaser LV, Zimmer D, Velychko S, Weng M, Holzner M, Arend M, Chen Y, Srivastava Y, Veerapandian V, Shah Z, Esteban MA, Wang H, Chen J, Sch?ler HR, Hutchins AP, Meijsing SH, Pott S, Jauch R. Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2. Nat Commun. 2019 08 02; 10(1):3477. PMID: 31375664.
      View in: PubMed
    7. Chen CF, Pohl TJ, Pott S, Zakian VA. Two Pif1 Family DNA Helicases Cooperate in Centromere Replication and Segregation in Saccharomyces cerevisiae. Genetics. 2019 01; 211(1):105-119. PMID: 30442759.
      View in: PubMed
    8. Israel JW, Chappell GA, Simon JM, Pott S, Safi A, Lewis L, Cotney P, Boulos HS, Bodnar W, Lieb JD, Crawford GE, Furey TS, Rusyn I. Tissue- and strain-specific effects of a genotoxic carcinogen 1,3-butadiene on chromatin and transcription. Mamm Genome. 2018 02; 29(1-2):153-167. PMID: 29429127.
      View in: PubMed
    9. Chappell GA, Israel JW, Simon JM, Pott S, Safi A, Eklund K, Sexton KG, Bodnar W, Lieb JD, Crawford GE, Rusyn I, Furey TS. Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice. Environ Health Perspect. 2017 10 16; 125(10):107006. PMID: 29038090.
      View in: PubMed
    10. Pott S. Simultaneous measurement of chromatin accessibility, DNA methylation, and nucleosome phasing in single cells. Elife. 2017 06 27; 6. PMID: 28653622.
      View in: PubMed
    11. Tran PLT, Pohl TJ, Chen CF, Chan A, Pott S, Zakian VA. PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes. Nat Commun. 2017 04 21; 8:15025. PMID: 28429714.
      View in: PubMed
    12. Pott S, Lieb JD. Single-cell ATAC-seq: strength in numbers. Genome Biol. 2015 Aug 21; 16:172. PMID: 26294014.
      View in: PubMed
    13. Pott S, Lieb JD. What are super-enhancers? Nat Genet. 2015 Jan; 47(1):8-12. PMID: 25547603.
      View in: PubMed
    14. Tropberger P, Pott S, Keller C, Kamieniarz-Gdula K, Caron M, Richter F, Li G, Mittler G, Liu ET, B?hler M, Margueron R, Schneider R. Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer. Cell. 2013 Feb 14; 152(4):859-72. PMID: 23415232.
      View in: PubMed
    15. Pott S, Kamrani NK, Bourque G, Pettersson S, Liu ET. PPARG binding landscapes in macrophages suggest a genome-wide contribution of PU.1 to divergent PPARG binding in human and mouse. PLoS One. 2012; 7(10):e48102. PMID: 23118933.
      View in: PubMed
    16. Gy?ry I, Boller S, Nechanitzky R, Mandel E, Pott S, Liu E, Grosschedl R. Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells. Genes Dev. 2012 Apr 01; 26(7):668-82. PMID: 22431510.
      View in: PubMed
    17. Liu ET, Pott S, Huss M. Q&A: ChIP-seq technologies and the study of gene regulation. BMC Biol. 2010 May 14; 8:56. PMID: 20529237.
      View in: PubMed
    18. Treiber T, Mandel EM, Pott S, Gy?ry I, Firner S, Liu ET, Grosschedl R. Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription- independent poising of chromatin. Immunity. 2010 May 28; 32(5):714-25. PMID: 20451411.
      View in: PubMed
    19. Hamza MS, Pott S, Vega VB, Thomsen JS, Kandhadayar GS, Ng PW, Chiu KP, Pettersson S, Wei CL, Ruan Y, Liu ET. De-novo identification of PPARgamma/RXR binding sites and direct targets during adipogenesis. PLoS One. 2009; 4(3):e4907. PMID: 19300518.
      View in: PubMed
    20. Lundin A, Bok CM, Aronsson L, Bj?rkholm B, Gustafsson JA, Pott S, Arulampalam V, Hibberd M, Rafter J, Pettersson S. Gut flora, Toll-like receptors and nuclear receptors: a tripartite communication that tunes innate immunity in large intestine. Cell Microbiol. 2008 May; 10(5):1093-103. PMID: 18088401.
      View in: PubMed
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