 Glucuronosyltransferase
"Glucuronosyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of UDPglucuronic acid to a variety of endogenous and exogenous compounds. EC 2.4.1.17.
| Descriptor ID |
D014453
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| MeSH Number(s) |
D08.811.913.400.450.480
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| Concept/Terms |
Glucuronosyltransferase- Glucuronosyltransferase
- Glucuronyltransferase
- UDP Glucuronyl Transferase
- Glucuronyl Transferase, UDP
- Transferase, UDP Glucuronyl
- Glucuronic Transferase
- Transferase, Glucuronic
- UDP Glucuronosyltransferase
- Glucuronosyltransferase, UDP
7-Hydroxycoumarin UDP Glucuronyltransferase- 7-Hydroxycoumarin UDP Glucuronyltransferase
- 7 Hydroxycoumarin UDP Glucuronyltransferase
- Glucuronyltransferase, 7-Hydroxycoumarin UDP
- UDP Glucuronyltransferase, 7-Hydroxycoumarin
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Below are MeSH descriptors whose meaning is more general than "Glucuronosyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Glucuronosyltransferase".
This graph shows the total number of publications written about "Glucuronosyltransferase" by people in this website by year, and whether "Glucuronosyltransferase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1982 | 0 | 1 | 1 | | 1983 | 0 | 1 | 1 | | 1984 | 1 | 0 | 1 | | 1985 | 1 | 0 | 1 | | 1989 | 1 | 0 | 1 | | 1996 | 0 | 1 | 1 | | 1997 | 0 | 2 | 2 | | 1998 | 1 | 0 | 1 | | 1999 | 2 | 0 | 2 | | 2000 | 1 | 1 | 2 | | 2001 | 1 | 1 | 2 | | 2002 | 5 | 1 | 6 | | 2003 | 4 | 3 | 7 | | 2004 | 5 | 0 | 5 | | 2005 | 6 | 1 | 7 | | 2006 | 6 | 1 | 7 | | 2007 | 7 | 1 | 8 | | 2008 | 5 | 0 | 5 | | 2009 | 0 | 2 | 2 | | 2010 | 5 | 2 | 7 | | 2011 | 5 | 1 | 6 | | 2012 | 2 | 0 | 2 | | 2013 | 2 | 1 | 3 | | 2014 | 4 | 0 | 4 | | 2015 | 3 | 3 | 6 | | 2016 | 2 | 0 | 2 |
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Below are the most recent publications written about "Glucuronosyltransferase" by people in Profiles.
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Zhang L, Huang H, Wang H, Chen J, Du G, Kang Z. Rapid evolution of hyaluronan synthase to improve hyaluronan production and molecular mass in Bacillus subtilis. Biotechnol Lett. 2016 Dec; 38(12):2103-2108.
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Toffoli G, Sharma MR, Marangon E, Posocco B, Gray E, Mai Q, Buonadonna A, Polite BN, Miolo G, Tabaro G, Innocenti F. Genotype-Guided Dosing Study of FOLFIRI plus Bevacizumab in Patients with Metastatic Colorectal Cancer. Clin Cancer Res. 2017 Feb 15; 23(4):918-924.
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Wang X, Wang H, Shen B, Overholser BR, Cooper BR, Lu Y, Tang H, Zhou C, Sun X, Zhong L, Favus MJ, Decker BS, Liu W, Peng Z. 1-Alpha, 25-dihydroxyvitamin D3 alters the pharmacokinetics of mycophenolic acid in renal transplant recipients by regulating two extrahepatic UDP-glucuronosyltransferases 1A8 and 1A10. Transl Res. 2016 12; 178:54-62.e6.
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Gammal RS, Court MH, Haidar CE, Iwuchukwu OF, Gaur AH, Alvarellos M, Guillemette C, Lennox JL, Whirl-Carrillo M, Brummel SS, Ratain MJ, Klein TE, Schackman BR, Caudle KE, Haas DW. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for UGT1A1 and Atazanavir Prescribing. Clin Pharmacol Ther. 2016 Apr; 99(4):363-9.
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Qin J, Kilkus J, Dawson G. The hyaluronic acid inhibitor 4-methylumbelliferone is an NSMase2 activator-role of Ceramide in MU anti-tumor activity. Biochim Biophys Acta. 2016 Feb; 1861(2):78-90.
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Roy HK, Turzhitsky V, Wali R, Radosevich AJ, Jovanovic B, Della'Zanna G, Umar A, Rubin DT, Goldberg MJ, Bianchi L, De La Cruz M, Bogojevic A, Helenowski IB, Rodriguez L, Chatterton R, Skripkauskas S, Page K, Weber CR, Huang X, Richmond E, Bergan RC, Backman V. Spectral biomarkers for chemoprevention of colonic neoplasia: a placebo-controlled double-blinded trial with aspirin. Gut. 2017 02; 66(2):285-292.
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House L, Ramirez J, Seminerio M, Mirkov S, Ratain MJ. In vitro glucuronidation of aprepitant: a moderate inhibitor of UGT2B7. Xenobiotica. 2015; 45(11):990-8.
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He Y, Cui J, He T, Bi Y. 5-azacytidine promotes terminal differentiation of hepatic progenitor cells. Mol Med Rep. 2015 Aug; 12(2):2872-8.
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RamÃrez J, Mirkov S, House LK, Ratain MJ. Glucuronidation of OTS167 in Humans Is Catalyzed by UDP-Glucuronosyltransferases UGT1A1, UGT1A3, UGT1A8, and UGT1A10. Drug Metab Dispos. 2015 Jul; 43(7):928-35.
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Wassenaar CA, Conti DV, Das S, Chen P, Cook EH, Ratain MJ, Benowitz NL, Tyndale RF. UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers. Cancer Epidemiol Biomarkers Prev. 2015 Jan; 24(1):94-104.
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