 Integrins
"Integrins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
| Descriptor ID |
D016023
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| MeSH Number(s) |
D12.776.543.750.705.408
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Integrins".
Below are MeSH descriptors whose meaning is more specific than "Integrins".
This graph shows the total number of publications written about "Integrins" by people in this website by year, and whether "Integrins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 2 | 0 | 2 | | 1992 | 2 | 0 | 2 | | 1994 | 2 | 0 | 2 | | 1996 | 2 | 1 | 3 | | 1997 | 2 | 1 | 3 | | 1998 | 1 | 0 | 1 | | 1999 | 1 | 0 | 1 | | 2000 | 1 | 2 | 3 | | 2001 | 0 | 1 | 1 | | 2002 | 2 | 4 | 6 | | 2003 | 2 | 0 | 2 | | 2004 | 1 | 1 | 2 | | 2005 | 0 | 3 | 3 | | 2006 | 1 | 2 | 3 | | 2007 | 1 | 1 | 2 | | 2008 | 0 | 1 | 1 | | 2009 | 3 | 0 | 3 | | 2010 | 3 | 2 | 5 | | 2012 | 2 | 1 | 3 | | 2013 | 3 | 0 | 3 | | 2014 | 1 | 2 | 3 | | 2015 | 0 | 2 | 2 | | 2016 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 | | 2019 | 1 | 1 | 2 | | 2020 | 0 | 2 | 2 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Integrins" by people in Profiles.
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Sattler L, Hanauer SB, Malter L. Immunomodulatory Agents for Treatment of Patients with Inflammatory Bowel Disease (Review safety of anti-TNF, Anti-Integrin, Anti IL-12/23, JAK Inhibition, Sphingosine 1-Phosphate Receptor Modulator, Azathioprine / 6-MP and Methotrexate). Curr Gastroenterol Rep. 2021 Dec 16; 23(12):30.
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Shaw LT, Mackin A, Shah R, Jain S, Jain P, Nayak R, Hariprasad SM. Risuteganib-a novel integrin inhibitor for the treatment of non-exudative (dry) age-related macular degeneration and diabetic macular edema. Expert Opin Investig Drugs. 2020 Jun; 29(6):547-554.
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Mehta V, Pang KL, Rozbesky D, Nather K, Keen A, Lachowski D, Kong Y, Karia D, Ameismeier M, Huang J, Fang Y, Del Rio Hernandez A, Reader JS, Jones EY, Tzima E. The guidance receptor plexin D1 is a mechanosensor in endothelial cells. Nature. 2020 02; 578(7794):290-295.
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Bailles A, Collinet C, Philippe JM, Lenne PF, Munro E, Lecuit T. Genetic induction and mechanochemical propagation of a morphogenetic wave. Nature. 2019 08; 572(7770):467-473.
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Frohne CC, Llano EM, Perkovic A, Cohen RD, Luke JJ. Complete response of metastatic melanoma in a patient with Crohn's disease simultaneously receiving anti-a4ß7 and anti-PD1 antibodies. J Immunother Cancer. 2019 01 06; 7(1):1.
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Ramirez-San Juan GR, Oakes PW, Gardel ML. Contact guidance requires spatial control of leading-edge protrusion. Mol Biol Cell. 2017 Apr 15; 28(8):1043-1053.
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Tarabar D, Hirsch A, Rubin DT. Vedolizumab in the treatment of Crohn's disease. Expert Rev Gastroenterol Hepatol. 2016; 10(3):283-90.
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Mezyk-Kopec R, Wyroba B, Stalinska K, Próchnicki T, Wiatrowska K, Kilarski WW, Swartz MA, Bereta J. ADAM17 Promotes Motility, Invasion, and Sprouting of Lymphatic Endothelial Cells. PLoS One. 2015; 10(7):e0132661.
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Martino MM, Briquez PS, Maruyama K, Hubbell JA. Extracellular matrix-inspired growth factor delivery systems for bone regeneration. Adv Drug Deliv Rev. 2015 Nov 01; 94:41-52.
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Yue J, Xie M, Gou X, Lee P, Schneider MD, Wu X. Microtubules regulate focal adhesion dynamics through MAP4K4. Dev Cell. 2014 Dec 08; 31(5):572-85.
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